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| 1 | Understanding the importance of autophagy in human diseases using Drosophila显示文摘Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms. | Arindam Bhattacharjee áron Szabó Tamás Csizmadia Hajnalka Laczkó-Dobos Gábor Juhász | 2019 | Journal of Genetics and Genomics2019，46，4： | 4 |
| 2 | Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling显示文摘 | Mawuenyega K G Forst C V Dobos KM | 2005 | Mol Biol Cell2005，16，1： | 1 |
| 3 | Neuroinflammation in Alzheimer's disease and major depression显示文摘 | Dobos N Korf J Luiten P G | 2010 | Biol Psychiatry2010，67，6： | 1 |
| 4 | Measuring skin aging using optical coherence tomography in vivo: a valida- tion study显示文摘 | Trojahn C Dobos G Richter C | 2015 | J Biomed Opt2015，20，04： | 1 |
| 5 | The significance of intrathecal catheter location in rats显示文摘 | Toth K Kekesi G | 2003 | Anesth Analg2003，96，1： | 1 |
| 6 | The antinociceptive potencies and interactions of endogenous ligands during continuous intrathecal administration: adenosine, agmatine, and endomorphin-1 显示文摘 | Kekesi G Dobos I Benedek G | 2004 | Anesth Analg2004，98，： | 1 |
| 7 | The Model of Western Integrative Medicine : the Role of Chinese Medicine显示文摘 | Dobos G Tao I | 2012 | Chin J Integr Med2012，18，9： | 1 |
| 8 | The CC chemokine receptor 3 CCR3 is functionally expressed on eosinoplils but not on neutrophils显示文摘 | Hochstetter R Dobos G Kimmig D | 2000 | Eur J Immunol2000，30，10： | 1 |
| 9 | Effects of phlebotomy- induced reduction of body iron stores on metabolic syndrome: re- suits from a randomized clinical trial 显示文摘 | Houschyar KS Ludtke R Dobos G J | 2012 | BMC Med2012，30，10： | 1 |
| 10 | A systematic review and meta- analysis of mindfulness - based stress reduction for the fihromyalgia syndrome显示文摘 | Lauche R Cramer H Dobos G | 2013 | J Psychosom Res2013，75，6： | 1 |
| 11 | The effects of ketamine and its enantiomers on the morphine-or dexmedetomidine-induced antinociception after intrathecal administration in rats显示文摘 | Jo6 G Horvath G Klimscha W Kekesi G Dobos I Szikszay M | 2000 | Anesthesiology2000，93，1： | 1 |
| 12 | Characterizing fa- cial skin ageing in humans: disentangling extrinsic from intrinsic biologi- cal phenomena显示文摘 | TROJAHN C DOBOS G LICHTERFELD A | 2015 | BioMed Res Int2015，2015，31： | 1 |
| 13 | Hydroconversion of acetic acid over carbon aerogel supported molybdenum catalyst显示文摘 | ábrahám D Nagy B Dobos G | 2014 | Microporous and Mesoporous Materials2014，190，19： | 1 |
| 14 | Biotechnological intensification ofbiogas production显示文摘 | Bagi Z Acs N Balint B Hovrath L Dobo K Perei K R Rakhely G Kovacs K L | 2007 | Applied Microbiology and Biotechnology2007，76，： | 1 |
| 15 | The value of switching costs 显示文摘 | Biglaiser G Cmer J Dobos G | 2013 | Journal of Economic Theory2013，148，3： | 1 |
| 16 | The antinociceptive potencies and interactions of endogenous ligands during continuous intrathecal administration: adenosine, agmatine, and endomorphin -1显示文摘 | KEKESI G DOBOS I BENEDEK G | 2004 | Anesth Analg2004，98，2： | 1 |
| 17 | Optimum crop densities for potential yield and harvestable yield of grain amaranth are conflicting显示文摘 | GIMPLINGER D M ERLEY G S DOBOS G | 2008 | Europ JAgronomy2008，28，2： | 1 |
| 18 | Expression of p27, p21^WAF/Cip1, and p16^INK4a in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma 显示文摘 | Queiroz AB Focchi G Dobo C | 2010 | Anticancer Res2010，30，7： | 1 |
| 19 | Impaired function of platelet membrane glycoprotein Ⅱ b-Ⅲ a in end-stage renal disease显示文摘 | Dobos G Spoh M | 1994 | J Am Soc Nephral1994，5，1： | 1 |
| 20 | The synergistic antinociceptive in- teractions of endomorphin-1 with dexmedetomidine and/or S(+ ) ketamine in rats 显示文摘 | Horvath G Joo G Dobos I et aI | 2001 | Anesth Analg2001，93，： | 1 |
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