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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 3 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 4 | Slump loss control of cement paste by adding polycarboxylic type slump-releasing dispersant 显示文摘 | GYE G SEONG S H DO S K | 1999 | Cem Concr Res1999，29，2： | 1 |
| 5 | Distribution of antibody ti-ters to mycoplasma pneumoniae in korean children in2000-2003显示文摘 | Yu J Yoo Y Kim do K | 2005 | J Korean Med Sci2005，20，4： | 1 |
| 6 | Corrective osteotomy for cubitus varus in middle - aged patients 显示文摘 | LIM T K KOH K H LEE DO K | 2011 | Shoulder Elbow Surg2011，20，3： | 1 |
| 7 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 8 | A peer-to-peer architecture for media streaming显示文摘 | Tran D A Hua K A Do T T | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 9 | Robust and adaptive path following for underactuated ships显示文摘 | Do K D Jiang Z P Pan J | 2004 | Automatica2004，40，： | 1 |
| 10 | Robust and adaptive path following for underactuated autonomous underwriter vehicles 显示文摘 | DO K D PAN J JIANG Z P | 2004 | Ocean Engineering2004，31，16： | 1 |
| 11 | Analytical and experimental investigation on the operational characteristics and the thermal optimization of a miniature heat pipe with a grooved wick structure 显示文摘 | Kim S J Seo J K Do K H | 2003 | International Journal of Heat and Mass Transfer2003，46，11： | 1 |
| 12 | The utility of three predictors of childhood myopia: a Bayesian analysis显示文摘 | Mutti DO Zadnik K | 1995 | Vision Res1995，35，： | 1 |
| 13 | Effect of Viscosity Ratio and Peroxide/Coagent Treatment in PP/EPR/PE Ternary Blends显示文摘 | I H Do L K Yoon B K Kim | 1992 | Eur Polym J1992，32，11： | 1 |
| 14 | Attenuation of apoptosis underlied B lymphocyte stimulator enhancement of humoral immune responses显示文摘 | Do R K Hatada E Lee H | 2000 | J Exp Med2000，192，： | 1 |
| 15 | Bounded controllers for formation stabilization of mo- bile agents with limited sensing ranges显示文摘 | Do K D | 2007 | IEEE Transactions on Automatic Control2007，52，3： | 1 |
| 16 | Closed form correlations for thermal optimization of plate-fin heat sinks under natural convection 显示文摘 | KIM T DO K H KIM D K | 2011 | International Journal of Heat and Mass Transfer2011，54，5： | 1 |
| 17 | Increased expression of basci fibroblast growth factor (bFGF) following focal cerebral infarction in the rat 显示文摘 | Elizabeth K Cornelio G Tuyen Do | 1996 | Molecular Brain Research1996，39，： | 1 |
| 18 | A Peer-to-Peer Architecture for Media Streaming显示文摘 | Tran D A Hua K A Do T T | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 19 | Postoperative spinal epidural hematoma:risk factor and clinical outcome显示文摘 | Yi S Yoon do H Kim K N | 2006 | Yonsei Med J2006，47，3： | 1 |
| 20 | Removal ofchlorophenols from groundwater by chitosan sorption显示文摘 | Zheng S K Yang Z F Do Hyun Jo | 2004 | Water Research2004，38，： | 1 |
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