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| 1 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 2 | 金龟子绿僵菌分生孢子暴露在B段紫外光下毒力的降低显示文摘The UV-A and UV-B wavelengths of solar radiation may seriously reduce viability of Metarhizium anisopliae conidia,a fungus used extensively in Brazil for insect pest control.The conidial tolerances to UV-A and UV-B radiation were studied for one isolate(IBCB 425) commercially available product produced on rice grains.Aqueous or oil emulsion conidial suspensions were irradiated for 0(control),2,or 3 h using the solar simulator filtered with diacetate filter to remove UV-C radiation which afforded 652 mW·m-2 in the spectral range of 280~370 nm.The UV tolerance was based on conidial germination(viability) and virulence to Diatraea saccharalis larvae.Conidia formulated with oil emulsion had higher survival after 3 h of UV exposure,but the virulence of the conidia previously exposed to 2 h of UV radiation were similar when oil formulated or not.The mortality of D.saccharalis caterpillars exposed to non-UV-irradiated conidia was greater than that of larvae exposed to irradiated conidia,and the LT50 values were lower for the non-irradiated suspensions than for those irradiated.This apparent reduction in virulence was directly related reduction in viability or delay of germination of UV-irradiated conidia. | Edimara A Francisco Drauzio E N Rangel Newton La Scala Jr José C Barbosa Antnia do C B Correia | 2008 | 安徽农业大学学报2008，35，2： | 2 |
| 3 | Chitosan-based femimagnetic membrane显示文摘 | M A Mace^do M N B Silva A R Cestari | 2004 | Physica B2004，，354： | 1 |
| 4 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 5 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 6 | Comparison of the efficacy of tenofovir and entecavir for the treatment of nucleos (t)ide-naive patients with chronic hepatitis B 显示文摘 | Do an UB Kara B Gtimtirdtilti Y | 2012 | Turk J Gastroenterol2012，23，3： | 1 |
| 7 | Effect of Viscosity Ratio and Peroxide/Coagent Treatment in PP/EPR/PE Ternary Blends显示文摘 | I H Do L K Yoon B K Kim | 1992 | Eur Polym J1992，32，11： | 1 |
| 8 | On predicting the effective elastic properties of polymer bonded explosives using the recursive cell method显示文摘 | Banerjee B Adams DO | | 0，，： | 1 |
| 9 | Purification of cxtracellular α -arnylasc from Bacillus subtilis by partitioning in a polyethylene glycol/potassium phosphate aqueous two-phase system显示文摘 | NGUYEN H L NGUYEN T M DO T B | 2010 | Ann Microbiol2010，60，4： | 1 |
| 10 | Development of specific nested oligonu-cleotide PCR primers for the Streptococcus inJae 16S-23S ribo-somal DNA inter-genic spacer 显示文摘 | B R FULLER DJ FULLER J AZAVE- DO | 1998 | Journal of Clinical Microbiology1998，36，9： | 1 |
| 11 | Cytochrome c release and caspase activation in traumatic axonal injury显示文摘 | Büki A Okonkwo DO Wang KK | | 0，，08： | 1 |
| 12 | Darapladib binds to lipoprotein- associated phospholipase A2 with meaningful interactions 显示文摘 | Do KR Kim C Chang B | 2014 | Bull Korean Chem Soc2014，35，： | 1 |
| 13 | Ovarian expression of melatonin Me(Ia)receptor mRNA during mouse development显示文摘 | DO B R Lee Y H | 2001 | Mol Reprod Dev2001，59，2： | 1 |
| 14 | The current status of international standards for child growth显示文摘 | Nita B Mercedes DO | 2007 | Indian J Med Res2007，126，2： | 1 |
| 15 | On Hyers-Ulam-Rassias stability of functional equations显示文摘 | Do Kim B | 2008 | Acta Math Sinica-English series2008，24，3： | 1 |
| 16 | LAGAN and Multi-LAGAN:Efficient tools for large-scale multiple alignment of genomic DNA显示文摘 | Brudno M Do C B Cooper G M | 2003 | Genome Res2003，13，4： | 1 |
| 17 | Fate of donor mitochondrial DNA in cloned bovine embryos produced by microinjection of cumulus cells显示文摘 | Do J T Lee J W Lee B Y | 2002 | Biol Reprod2002，67，2： | 1 |
| 18 | The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses显示文摘 | Wells GA Shea B Connell DO | 2002 | Appl Eng Agric2002，18，6： | 1 |
| 19 | Impact of milk consumption on performance and health of primary school children in rural Vietnam 显示文摘 | LIEN DO T K NHUNG B T KHAN N C | 2009 | Asia Pac J Clin Nutr2009，18，3： | 1 |
| 20 | A spatio-temporal deconvolution method to improve perfusion CT quantification显示文摘 | He L Orten B Do S | 2010 | IEEE Trans Med Imageing2010，29，5： | 1 |
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