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| 1 | Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression显示文摘Heart failure is common in adult population,accounting for substantial morbidity and mortality worldwide.The main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic therapy.The main factor associated with poor outcome of these patients is constant progression of heart failure.In the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the'ideal biomarker.'A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management purposes.Moreover,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the disease.The authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection fraction.One could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse remodeling.This article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis. | Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin Yuri V Cheburkin Mikhail M Galagudza | 2021 | Journal of Geriatric Cardiology2021，18，1： | 4 |
| 2 | Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants显示文摘 | Svetlana V Garkina Tatiana V Vavilova Dmitry S Lebedev Evgeny N Mikhaylov | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 3 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 4 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 5 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 6 | A study of glassformation, formation of the supercooled liquid and devitrification behavior of Ni-based bulk glass-forming alloys显示文摘 | Dmitri V L-L Shimada T Inoue A | 2007 | Materials Science and Engineering A2007，，： | 1 |
| 7 | Comprehensive study on the chemical structure of dioxane lignin from plantation eucalyptus globulus wood 显示文摘 | DMITRY V Evtuguin CARLOS Pascoal Neto ARTUR M S Silva | 2001 | Journal of Agricultural and Food Chemistry2001，49，9： | 1 |
| 8 | Designing catastrophe bonds to securitize systemic risks in agriculture: The case of Georgia cotton 显示文摘 | Dmitry V James E Barry J | 2006 | Journal of Agriculture and Resource Economics2006，31，2： | 1 |
| 9 | Application of Magic-Angle Spinning NMR to Examine the Nature of Protons in Titanate Nanotubes显示文摘 | Bavykin Dmitry V Carravetta Marina Kulak Alexander N | 2010 | Chemistry of Materials2010，22，8： | 1 |
| 10 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS Nano2010，4，8： | 1 |
| 11 | Prospects of colloidal nanocrystals for electronic and op- toelectronicapplications显示文摘 | Dmitri V Talapin Jong-Soo Lee Maksym V Kovalenko | 2010 | Chem Rev2010，110，： | 1 |
| 12 | Time tuning of ferroelectric film varactors under pulse voltages 显示文摘 | ANDREY B VITALY V O DMITRY M K | 2007 | Applied Physics Letters2007，91，02： | 1 |
| 13 | Improved synthesis of graphene oxide显示文摘 | Daniela C Marcano Dmitry V Kosynkin | 2010 | ACS nano2010，4，8： | 1 |
| 14 | Long term mortality after severe starvation during the seige of leningard : prospective cohort study 显示文摘 | Par S Denny V Dmitri BS | 2004 | BMJ2004，328，7430： | 1 |
| 15 | Effect of Two-and Three-locus linkage disequilibrium on the power to detect marker/phenotype associations显示文摘 | Dahila M N Margaret G E Dmitri V Z | 2004 | Genetics2004，168，： | 1 |
| 16 | Transcript profiling of human platelets using microarray and serial analysis of gene expression 显示文摘 | Dmitri V Gnatenko John J | 2003 | Blood2003，101，： | 1 |
| 17 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS Nano2010，4，： | 1 |
| 18 | Carcinosarcoma of the urinary bladder I an ag- gressive tumor with diverse histogenesis 显示文摘 | DMITRY Y B JANNY H C MANJUNATH S V | 2000 | Arch Path Lab Med2000，124，： | 1 |
| 19 | Optical Solitons Due to Qquadratic Nonlinearities:From Basic Physics to Futuristic Applications显示文摘 | Buryak Alexander V Trapani Paolo Di Skryabin Dmitry V | 2002 | Physics Reports2002，370，： | 1 |
| 20 | Solid state properties of 1,2-epoxy-3-(2-methoxyphenyloxy)-propane--valuable intermediate in non-racemie drug synthesis显示文摘 | Alexander A B Elena I S Dmitry V Z | 2005 | Tetrahedron: Asymmetry2005，16，： | 1 |
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