|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 3 | Chlorophyll b can serve as the major pigment in functional photosystem Ⅱ complexes of cyanobacteria显示文摘 | Hong X Dmitrii V Wire V | 2001 | The proceeding of the National Academy of Science of the USA2001，98，14： | 1 |
| 4 | Member lipid peroxidation,cell viability and photosystemⅡactivity in the green alga chlorella pyrenoidosa subjected to various stress conditions显示文摘 | Dmitrii V V Jean-Marc D Dmitrii N M | 1998 | Journal of photochemistry and photobiology B: Biology1998，42，： | 1 |
| 5 | Oxidation of H2S on activated carbon KAU and influence of the surface state显示文摘 | Dmitrii V B Yuri P Z Irina V B | 2007 | Appl Catal B: Environ2007，70，14： | 1 |
| 6 | Optical and Mechanical Properties of AlN Thin Films Deposited by Reactive Magnetron Sputtering显示文摘 | Dmitriy A Golosov Sergey M Zavatskiy | 2006 | Journal of Xi''an Institute of Technology2006，26，3： | 1 |
| 7 | Identification of MicroRNAs Controlling Human Ovarian Cell Steroidogenesis Via a Genome-Scale Screen显示文摘 | Alexander V S Dmitriy O Roland G | 2009 | Cell Physiol2009，219，： | 1 |
| 8 | Experimental and theoretical investigation of oxygen glow discharge structure at low pressures显示文摘 | Vlasimir V I Konstantin S K Dmitriy V L | 1999 | IEEE Transaction on Plasma Science1999，27，5： | 1 |
| 9 | Impact on molec- ular organization of amylopectin in starch granules upon an- nealing显示文摘 | VaratharajanV Eric B Dmitriy V S | 2013 | Carbohydrate Polymers2013，98，1： | 1 |
| 10 | Hemostasis of massive bleeding from esophageal tumor:A case report显示文摘BACKGROUND Esophageal cancer is a common type of cancer and serious bleeding from esophageal tumors can occur in routine clinical practice.The arrest of bleeding from esophageal tumor is not a trivial task,which can sometimes require non-standard solutions.We report a case of successful hemostasis of massive bleeding from esophageal tumor performed by a novel two-balloon catheter inserted endoscopically,with a local hemostatic treatment applied.CASE SUMMARY A 36-years old male patient with advanced esophageal cancer developed bleeding from the tumor following endoscopic stenting with a self-expanding metal stent.Due to the ineffectiveness of standard approaches,after a medical conference,the patient was treated with a novel method based on the use of a two-balloon catheter creating an isolated area in esophagus and locally dispersing hemostatic polysaccharide powder inside the isolated interior.Hemostasis was successful and subsequent endoscopic examination revealed the presence of organized clot and localized defect,which was coagulated in a planned manner.CONCLUSION The authors present a new catheter-based method of hemostasis of esophageal tumor bleeding. | Aleksei A Kashintsev Dmitriy S Rusanov Mariya V Antipova Sergey V Anisimov Oleg K Granstrem NikolaiYu Kokhanenko Konstantin V Medvedev Eldar B Kutumov Anastasya A Nadeeva Vitali Proutski | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 11 | Oxidation of H2S on activated carbon KAU and influence of the surface state 显示文摘 | Brazhnyk Dmitrii V Yuri P Zaitsev Irina V Bacherikova | 2007 | Applied Catalysis B: Environmental2007，70，14： | 1 |
| 12 | Experimental and theoretical investigation of oxygen glow discharge structure at low pressures 显示文摘 | Vlasimie V I Konstantin S K Dmitriy V L | 1999 | IEEE Transaction on Plasma Science1999，27，5： | 1 |
| 13 | Photoswitchable cyanfluorescent protein for protein tracking 显示文摘 | Dmitriy M C Vladislav V V Dmitry B | 2004 | Nature Biotechnology2004，11，： | 1 |
| 14 | Comparative characteristic of energy content calculating methods for the furazan series as an example of energetic materials显示文摘 | Tatyana S P Dmitrii V S | 1995 | Propellants Explositves Pyrotechnica1995，20，1： | 1 |
| 15 | Mechanism of zine oxide single crystal growth under hydrothermal conditions 显示文摘 | Lioudmila N Demianets Dmitriy V Kostomarov | 2001 | Ann Chim Scl Mat2001，26，： | 1 |
| 16 | Stochastic Resonance in Electrical Circuits-Ⅱ:Nonconventional Stochastic Resonance显示文摘 | Riccardo Mannella Peter V E McClintock | 1999 | IEEE Transactions1999，46，1： | 1 |
| 17 | Retinal nerve fiber layer changes after LASIK evaluated with op tical coherence显示文摘 | Dmitriy D Vyacheslav V Kourenkow D | 2005 | J Refract Surg2005，21，6： | 1 |
| 18 | Simultaneous Analysis of Multiple Staphy lococcal Enterotoxin Genes by an Oligonucleotide Microarray As say显示文摘 | Nikolay S Dmitriy V | 2004 | Journal of Clinical Microbiology2004，42，5： | 1 |
| 19 | Identification of Listefia species by mieroarray - based assay 显示文摘 | Dmitriy V Avraham R Konstantin C | 2002 | J Cfin Mierobiol2002，40，12： | 1 |
| 20 | Influence of dust particles on spatial distributions of particles and fluxes in positive column of glow discharge显示文摘The research herein examined the results of numerical simulations of the positive column of a glow discharge in argon dusty plasma using COMSOL Multiphysics software under conditions similar to the project known as PK-4.Various scenarios dealing with formations of spatial distributions of densities and fluxes for charged particles were studied,and evaluations of the influence of dust particles on the discharge were obtained in a wide range of dust densities.Two extreme cases were distinguished:weak dust influence when the densities,fluxes and electric field profiles are not perturbed,and strong dust influence when all three density profiles(electrons,ions and charged dust)in the dust cloud are similar(parallel)to each other,resulting in all created charges in the dust cloud being lost inside the cloud.In such a case,the ambipolar field and the transport of charged particles are decreased in the dust cloud,and any ambipolar flux is almost absent within the cloud. | 田瑞焕 袁承勋 Dmitrii V BOGDANOV Evgeniy A BOGDANOV Anatoly A KUDRYAVTSEV 周忠祥 | 2019 | Plasma Science and Technology2019，21，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员