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| 1 | Integrating of lipophilic platinum(IV) prodrug into liposomes for cancer therapy on patient-derived xenograft model显示文摘Platinum-based anticancer agents such as cisplatin and its analogues are widely used for treating multiple cancers. However, due to the inferior water-solubility, chemoresistance and consequent adverse side effects, their clinical applications are limited. Herein, choles Pt(IV), a lipophilic platinum(IV) prodrug was synthesized for manufacture of Choles Pt(IV)-Liposomes aiming to resolve the predefined obstacles encountered by platinum drugs. Following systematic screening, Choles Pt(IV)-Liposomes showed a small particle size(105.6 nm), the rapid release of platinum(Pt) ions, and notable apoptosis of cancer cells.In addition, according to the fluidity and safety results of animal experiments in mice, Choles Pt(IV)-Liposomes also showed better therapeutic effect, which significantly inhibited the growth of patientderived xenograft tumors of hepatocellular carcinoma with an inhibition ratio of 80.7%, and effectively alleviated the drug toxicity brought by traditional platinum drugs. Overall, this study provides a promising route to enhance the therapeutic efficiency of platinum drugs in cancer treatment. | Zibo Li Qing Xu Xuefeng Lin Kunyi Yu Ling Lin Yangjia Liu Zhiqiang Yu Tiancai Liu Dixian Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 2 | Static pressure accelerates ox-LDL-induced cholesterol accumulation via SREBP-l-mediated caveolin-1 downregulation in cultured vascular smooth muscle cells 显示文摘 | LUO Dixian XIA Chenglai LI Junmu | 2010 | Biochem Biophys Res Commun2010，403，1： | 1 |
| 3 | Highly fluorescence Ta_(4)C_(3) MXene quantum dots as fluorescent nanoprobe for heavy ion detection and stress monitoring of fluorescent hydrogels显示文摘Compared with other transition metal Mxene derived quantum dots(MQD_(S)),Ta-based Mxene quantum dots have good functionality,but Ta-based Mxene quantum dots and their applications have not been studied so far.In this paper,we report for the first time the synthesis of high fluorescence quantum yield(QY) N-doped Ta_(4)C_(3) quantum dots(N-MQDs) using Ta_(4)C_(3) quantum dots in acid reflux damaged Ta_(4)C_(3) nanosheets as precursors and ethylenediamine as nitrogen source.The prepared N-MQDs have excellent blue photoluminescence(PL) properties,particle size is only 2.60 nm,QY is up to 23.4%,and good stability.In addition,it has been reported that N-MQDs can be used as fluorescent probe for detection of Fe;and remote force sensing analysis In liquid ion sensing,N-MQDS shows a unique selective quenching of Fe;with a detection limit as low as 2 μmol/L,and has great potential as a fast and super-sensitive fluorescent probe for the detection of heavy ion.More importantly,in solid mechanics sensing,the introduction of N-MQDs into self-healing hydrogels can be developed into a fluorescent hydrogel that can be used for accurate remote force measurement and applied in the field of mechanical sensing analysis.Therefore,Ta-based N-MQDs show excellent potential in the field of fluorescence sensing,which provides a door for multi-dimensional sensing of new materials in the future. | Shouzhen Li Junfei Ma Xuelin Zhao Peide Zhu Meng Xu Yingchun Niu Dixian Luo Quan Xu | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 4 | Improved EGFR mutation detection sensitivity after enrichment by Cas9/sgRNA digestion and PCR amplification显示文摘The detection of circulating tumor DNA is im portant in cancer research and clinical practice.In the present study,we aimed to im prove the sensitivity of downstream m utation detection of next-generation sequencing using the clustered regularly interspaced short palindrom ic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system to selectively target w ild-type fragm ents but with low or no cleavage activity to m utant fragm ents,follow ed by am plification using polymerase chain reaction.We selected different m utant sites of epidermal growth factor receptor gene(EGFR)-exon19 deletions in patients w ith lung cancer and constructed mixed tem plates o f m utant and wildtype DNA com prising ratios of 10%to 0.01%to test the effectiveness of the enrichm ent method.The results showed that after CRISPR/Cac9 enrichment,a low concentration of m utant DNA fragments(0.01%)could be detected by Sanger sequencing,which represented a 1000-fold increase com pared with the untreated samples.We further verified the feasibility of the introduced method and obtained sim ilar results in clinical samples from patients with non-small cell lung cancer,indicating that this method has the potential to detectlow copy number mutations at the early stage. | Li Wang Jing Jiang Xiangning Li Kai Li Rongzhang He Jia Li Lili Duan Weihao Luo Zheng Hu Dixian Luo | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 0 |
| 5 | MOPCS:next-generation nucleic acid molecular biosensor显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has had a huge impact on the world,causing millions of deaths and a serious blow to the global economy.SARS-CoV-2 can aack most body tissues with devastating consequences^([1]). | Quan Liu Shang Chen Li Wang Zhaojun Duan Fuquan Xie Guojun Zhao Yunde Hou Dixian Luo | 2022 | National Science Review2022，9，9： | 0 |
| 6 | AKR1B10 protects against UVC-induced DNA damage in breast cancer cells显示文摘The cellular response to DNA damage is crucial for maintaining the integrity and stability of molecular structure.To maintain genome stability,DNA-damaged cells should be arrested so that mutations can be repaired before replication.Although several key components required for this arrest have been discovered,the majority of the pathways are still unclear.Through a number of assays,including cell viability,colony formation,and apotheosis assay,we found that AKR1B10 protected cells from UVC-induced DNA damage.Surprisingly,UVC-inducedγH2AX foci and DNA double-strand breaks in the AKR1B10-overexpressing cells were~4-5 folds lower than those in the control group.The expression levels of AKR1B10,p53,chk1,chk2,nuclear factor(NF)-κB,and p65 showed dynamic changes in response to UVC irradiation.Our results suggested that AKR1B10 is involved in the pathway of cell cycle checkpoint and NF-κB in DNA damage.Taken together,our results suggest that AKR1B10 is involved in the repair of the DNA double-strand break,which provides a new insight into the role of AKR1B10 in DNA damage repair and indicates a new trail in tumorigenesis and cancer drug resistance. | Yuanqing Zeng Jia Li Wangyuan Guo Weihao Luo Xiangting Liu Rongzhang He Zheng Hu Lili Duan Chenglai Xia Dixian Luo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 0 |
| 7 | β-Cyclodextrin derived full-spectrum fluorescent carbon dots: The formation process investigation and biological applications显示文摘Carbon dots(CDs), a new building unit, have been revolutionizing the fields of biomedicine, bioimaging, and optoelectronics with their excellent physical, chemical, and biological properties. However, the difficulty of preparing excitation-dependent full-spectrum fluorescent CDs has seriously hindered their further research in fluorescence emission mechanisms and biomedicine. Here, we report full-spectrum fluorescent CDs that exhibit controlled emission changes from purple(380 nm) to red(613 nm) at room temperature by changing the excitation wavelength, and the excitation dependence was closely related to the regulation of sp2 and sp3 hybrid carbon structures by β-cyclodextrin-related groups. In addition,by regulating the content of β-cyclodextrin, the optimal quantum yields of full-spectrum fluorescent CDs were 8.97%, 8.35%, 7.90%, 9.69% and 17.4% at the excitation wavelengths of 340, 350, 390, 410 and 540 nm,respectively. Due to their excellent biocompatibility and color tunability, full-spectrum fluorescent CDs emitted bright and steady purple, blue, green, yellow, and red fluorescence in MCF-7 cells. Moreover, we optimized the imaging conditions of CDs and mitochondrial-specific dyes;and realized the mitochondrialtargeted co-localization imaging of purple, blue and green fluorescence. After that, we also explored the effect of full-spectrum fluorescent CDs in vivo fluorescence imaging through the intratumorally, subcutaneously, and caudal vein, and found that full-spectrum fluorescent CDs had good fluorescence imaging ability in vivo. | Peide Zhu Wenjing Li Yuqi Zhang Qiang Sun Yi Lin Ailin Qiu Xinyi Chen Yujin Zhou Guangfu Wu Yifan Li Zhiqiang Yu Quan Xu Dixian Luo Lulu Cai | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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