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1篇 您的检索式:作者名="Divor Kiseljak"
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1Large-scale mapping of the Ebola NP and GP proteins reveals multiple immunoprevalent and conserved CD4 T-cell epitopes显示文摘Humankind faces regular outbreaks from emerging viruses,such as Ebola and the current SARS-CoV-2,or from viruses circulating at low levels in the wild animal reservoir.Owing to the suddenness of virus expansion,the lack of knowledge of immune determinants and correlates of protection severely limit the ability to address the outbreaks.Identified in 1976,Ebola virus is part of the Filoviridae family and causes severe hemorrhagic fever with a mortality rate between 50%and 90%.From 2013 to 2020,more than 30,000 infections and 15,000 deaths have been reported worldwide.High antibody titers against Ebola virus GP are found in patients recovering from Ebola virus infection and correlate with protection in vaccination models.1 Both CD8 and CD4 T-cell responses also seem to participate in the control of Ebola virus infection in animals,and CD4 T cells are necessary to induce resistance to Ebola virus challenge.Yann Gallais Raphaël Sierocki Gautier Lhomme Coline Sivelle Divor Kiseljak Florian Wurm Sami Djoulah Ahmed Bouzidi Jérôme Kerzerho Bernard Maillère 2021Cellular & Molecular Immunology2021,18,5:0
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