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| 1 | Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell lines显示文摘This study aimed to investigate the effects of arsenic trioxide(As2O3) on the mitochondrial DNA(mtDNA) of acute promyelocytic leukemia(APL) cells.The NB4 cell line was treated with 2.0 μmol/L As2O3 in vitro,and the primary APL cells were treated with 2.0 μmol/L As2O3 in vitro and 0.16 mg kg-1 d-1 As2O3 in vivo.The mitochondrial DNA of all the cells above was amplified by PCR,directly sequenced and analyzed by Sequence Navigatore and Factura software.The apoptosis rates were assayed by flow cytometry.Mitochondrial DNA mutation in the D-loop region was found in NB4 and APL cells before As2O3 use,but the mutation spots were remarkably increased after As2O3 treatment,which was positively correlated to the rates of cellular apoptosis,the correlation coefficient:rNB4-As2O3=0.973818,and rAPL-As2O3=0.934703.The mutation types include transition,transversion,codon insertion or deletion,and the mutation spots in all samples were not constant and regular.It is revealed that As2O3 aggravates mtDNA mutation in the D-loop region of acute promyelocytic leukemia cells both in vitro and in vivo.Mitochondrial DNA might be one of the targets of As2O3 in APL treatment. | MENG Ran1,ZHOU Jin2,SUI Meng3,LI ZhiYong4,FENG GuoSheng1 & YANG BaoFeng2 1 Division of Neurology,the Ninth Clinical Medical College of Beijing University(Shijitan Hospital),Beijing 100038,China 2 The First Hospital of Harbin Medical University,Harbin 150001,China 3 Management Information System,University of International Business and Economics,Beijing 100029,China 4 Department of Radiology,Cambridge University Hospitals NHS Foundation Trust Box 219 Level 5,Addenbrooke’s Hospital Cambridge CB2 0QQ,UK | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 2 | 2010年全国林业统计分析报告显示文摘从营造林、产业发展、林业投资、主要林产品进出口贸易、劳动工资及安全生产5个方面进行了统计分析。结果表明:2010年我国生态公益林保持较高比重,乡土树种占较高比重,混交林所占比重有待提高,国家林业重点工程完成造林面积比2009年减少20.16%。2010年林业产业总产值首次突破2万亿元大关,达到2.28万亿元(按现价计算),比2009年增长30.21%;木材产量为8089.62万m3,比2009年增长14.45%;人造板产量15360.83万m3,是近5年来增长速度最快的一年。2010年,林业系统实际到位各类建设资金1662.56亿元,比2009年增长20.66%;林业公共财政支持制度初步建立,强林惠林政策体系初步形成。2010年,我国林产品进出口贸易呈现增长势头强劲、均衡发展良好态势;全国林产品进出口贸易总额为962.7亿美元,比2009年增长37.1%。截至2010年底,全国林业系统各种经济类型单位共计46396个;林业系统在岗职工年平均工资首次突破2万元。 | Division of Development Planning and Funds Management of State Forestry Administration | 2011 | 林业经济2011，，5： | 5 |
| 3 | 支撑国土资源管理 服务经济社会发展 促进地籍信息化建设再上新台阶显示文摘地籍工作是国土资源管理的基础,是一项打基础、利长远的工作。从原国家土地管理局到建部以来,地籍信息化建设一直未曾停止过,取得了重要进展和明显成效。1多年来特别是"十一五"期间,我国地籍信息化建设成效显著我国地籍信息化建设呈三个阶段性特点:一是起步早;二是发展快;三是成效显著。 | Department of Cadastral Management Division,ministey ot Lane and Resources | 2012 | 国土资源信息化2012，，2： | 2 |
| 4 | The UK Research Assessment Exercise 2001:an analysis for hospitality research显示文摘 | David Littlejohn Travel and Hospitality Division of Management Caledonian Business School Glasgow Caledonian University Glasgow Scotland G4 0BA UK | 2004 | Hospitality2004，23，2004： | 1 |
| 5 | Constructability and constructability programs:White paper显示文摘 | The Construction Management Committee of the ASCE Construction Division | 1991 | Journal of Construction Engineering and Management1991，，1： | 1 |
| 6 | 我国无线寻呼业的快速发展与市场管理显示文摘我国无线寻呼业经过十几年的发展,已经走上了依法管理、健康有序发展的轨道。随着技术的进步和用户需求的变化,业务市场仍在扩大,尽管竞争日趋激烈,但前景依然看好。 文中针对目前经营中存在的问题提出了几点新的要求,以引导和规范市场行为。 | Telecom Service Market Management Division, Department of Telecommunications Administration of MPT | 1997 | 世界电信1997，10，2： | 0 |
| 7 | 森林采伐作业规程(英文)显示文摘Name of Project:LY/T 1646—2005 Code of Forest Harvesting Main Participant Units:Department of Forest Resources Management of State Forestry Administration(SFA),Academy of Forest Inventory and Planning of SFA,Chinese Academy of Forestry Sciences Main Contributors:Zhang Songdan,Tang Xiaoping,Cui Wushe,Zhang Yu,Wang Hongbo,Chen Yongfu,Xie Shouxin, Wang Hongchun,Zhang Huiru,Du Jishan Award Grade:First | Zhang Songdan Deputy Director General of the Department of Forest Resources Management of the SFA in charge of national forest harvesting management Tang Xiaoping Deputy Director General of the Academy of Forest Inventory, Planning and Design of lhe SFA, enjoying Special Government Subsidy of the State Council Cui Wushe Deputy Division Director of the Department of Forest Resources Management of the SFA | 2011 | China Standardization2011，56，3： | 0 |
| 8 | Hydrower Stations and Its Comprehensive Automation in Northeast China显示文摘This paper mainly presents the status anddevelopment of hydropower in NortheastChina, including the retrofit and extension-uprating for the old stations and describes thecomprehensive automation system with theunit’s automation system. dam safetymonitoring automation system and reservoirdispatching system as the bases. The paperalso puts forward a target to realize themodernization of hydropower station in2010. | Wu Runze(Hydropower Management Division of NEPGC) | 1997 | Electricity1997，，2： | 0 |
| 9 | Integrated System of Economy-Environment Accounting of China (CSEEA)─System Design and Trial Estimation (1992)显示文摘On the basis of the general framework of United Nations′ ″indirect/satellite″ accounting system--Integrated System of Environment & Economy Accounting SEEA (1992) and 93′ SNA, this paper tries to construct one simple, effective and practical CSEEA, and thereby trial estimates the 1992 Chinese environmental adjusted GDP (Green GDP), under Chinese National Accounting System′s reform practice. | LEI Ming Guanghua School of Management, Peking University, China Division of Social System Planning for Energy, Graduate School of Energy Science, Kyoto University, Japan | 2001 | Journal of Systems Science and Systems Engineering2001，13，3： | 0 |
| 10 | THE RATIONAL UTILIZATION OF WATER RESOURCES IN IRRIGATED AREA OF THE YELLOW RIVER IN NINGXIA显示文摘The paper describes the water resources in the irrigated area of Ningxia, China, andthe methods for improving the utilization of the water resources, and puts forward somesuggestions so as to utilize the water resources rationally. The history of irrigation farming in Ningxia can be traced back to more than two thou- | Liu Baizhang Fang Wanjun Working Office of First Phase Daliushu Project, Department of Water Conservancy of Ningxia,China Division of Management of Tanglai Canal, Department of Water Conservancy of Ningxia, China | 1993 | 干旱区资源与环境1993，7，Z1： | 0 |
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