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| 1 | Micro RNAs in the development of non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD) refers to a group of disorders that arise from the accrual of fat in hepatocytes. Although various factors have been associated with the development of NAFLD, including genetic predisposition and environmental exposures, little is known aboutthe underlying pathogenesis of the disease. Research efforts are ongoing to identify biological targets and signaling pathways that mediate NAFLD. Emerging evidence has implicated a role for micro RNAs(mi RNAs), short single-stranded molecules that regulate gene expression either transcriptionally, through targeting of promoter regions, or post-transcriptionally, by blocking translation or promoting cleavage of specific target m RNAs. Several mi RNAs have been associated with NAFLD, although our understanding of the biology underlying their role is still emerging. The goal of this review is to present an overview of the current state of knowledge of mi RNAs involved in the development of NAFLD across a range of in vitro and in vivo models, including mi RNAs that contribute to pathological mechanisms related to fatty liver in humans. Much less is known about the specific targets of mi RNAs in cells, nor the molecular mechanisms involved in the development and progression NAFLD and related outcomes. More recently, the identification and validation of mi RNA signatures in serum may facilitate the development of improved methods for diagnosis and clinical monitoring of disease progression. | Glenn S Gerhard Johanna K DiStefano | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 2 | Human cytomegalovirus: detection of congenital and perinatal infection in Argentina 显示文摘 | Distefano AL Alonso A Martin F | 2004 | BMC Pediatr2004，23，1： | 1 |
| 3 | Enchanced restoration of striatal dopamine concentrations by combined GMI ganglioside and neurotrophic factor treatments显示文摘 | SchneiderJS DiStefano L | 1995 | Brain Res1995，674，2： | 1 |
| 4 | Neoadjuvant treatment of locally advanced carcinoma of the uterine cervix with epirubicin,paclitaxel and cisplatin显示文摘 | D'Agostino G Distefano M Greggi S | 2002 | Cancer Chemother Pharmacol2002，49，3： | 1 |
| 5 | Histological and molecular analysis of pollerrpistil interaction in demenfine显示文摘 | DISTEFANO G CARUSO M LA MALFA S | 2009 | Plant Cell Reports2009，28，9： | 1 |
| 6 | Differential activation of NGF receptor and early response genes in neural crest-derived cells显示文摘 | Matheny C DiStefano PS Milbrandt J | 1992 | Brain Res Mol Brain Res1992，13，12： | 1 |
| 7 | Pregnancy - associated ehanges in bone density and bone turnover in the physiological state: prospective data on sixteen women 显示文摘 | Fiore CE Pennisi P Distefano A | 2003 | Honn Metab Res2003，35，5： | 1 |
| 8 | Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury显示文摘 | Valenzuela DM Sitt TN Distefano PS | 1995 | Neuron1995，15，： | 1 |
| 9 | The neurotrophins BDNF,NT-3,and NG F display distinct patterns of retrograd e axonal transport in peripheral and cen teral neurons显示文摘 | Distefano PS Friedman B Radziejewskic | 1992 | Nuron1992，8，： | 1 |
| 10 | Clinico-pathologic, immunohistochemical, and TUNEL study in early cardiac allograft failure显示文摘 | Panizo-Santos A Lozano MD Distefano S | 2000 | Cardiovasc Pathol2000，9，3： | 1 |
| 11 | Increased cyelooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients显示文摘 | Ferrandina G Lauriola L Distefano MG | | 0，，： | 1 |
| 12 | Elsevier reliability and availability analysis of dependent dynamic systems with DRBDs 显示文摘 | Distefano S Puliafito A | 2009 | Relia bility Engineering - System Safety2009，94，13： | 1 |
| 13 | Human cy-tomegalovirus:detection of congenital and perinatal in-fection in Argentina显示文摘 | Distefano A L Alonso A Martin F | 2004 | BMC Pediatr2004，4，1： | 1 |
| 14 | Cellular distribution of GAP-43mRNA in hippocampus and cerebellum of adult rat brain by in situ RT-PCR 显示文摘 | Casoli T DiStefano G | 2001 | Histochem Cytochem2001，49，9： | 1 |
| 15 | Simulation of tumor - induced angiogenesis and its response to anti -angiogenic drug treatment: mode of drug delivery and clearance rate dependencies 显示文摘 | Tee D DiStefano | 2004 | J Cancer Res Clin Oncol2004，130，： | 1 |
| 16 | Evaluation of transdermal theophylline pharmacokinetics in neonates显示文摘 | Micali G Bhatt RH Distefano G | 1993 | Pharmacotherapy1993，13，4： | 1 |
| 17 | The Internet serf-perception scale: Measuring elementary students' levels of self-efficacy re- garding Internet use 显示文摘 | Hinson J DiStefano C Daniel C | 2003 | Journal of Educational Computing Re- search2003，29，2： | 1 |
| 18 | Characterization of the curing process from high solids anaerobic digestion 显示文摘 | Drennan M F DiStefano T D | 2010 | Bioresource Technology2010，101，2： | 1 |
| 19 | Beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells显示文摘 | Marino M Distefano E Caporali S | 2001 | J Cell Physiol2001，188，2： | 1 |
| 20 | Synergistic antiproliferative activity of tamoxifen and docetaxed on three oestrogen receptomegaive cancer cell Lines is mediated by induction of apoptosis显示文摘 | Ferlini C Scambia G Distefano M | 1997 | Br J Cancer1997，75，： | 1 |
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