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| 1 | Quick to remember, slow to forget: rapid recall responses of memory CD8^+ T cells显示文摘记忆 B 和 T 淋巴细胞的功能的角色位于预防种痘的非凡的成功下面,它减少了从传染疾病的病态和死亡全球性在最后 50 年。然而,逐渐地欣赏了那,正在变得记忆房间也能够调停与自体免疫的混乱联系的病理并且移植拒绝,并且可以提出一个重要障碍到未来在 immunoregulation 的临床的前进。因此,理解记忆淋巴细胞的唯一的性质(作为与他们的天真的先锋相比) 是调查的一个主要区域。这里,我们集中于记忆 T 房间(TM ) 的那些单个性质之一鈥攔a pid 召回。当愿望更详细地被讨论,快速的召回指静止 TM 房间的能力到“高效地并且要用体力地快速的受动器功能”跟随刺激。用 CD4+ T 房间推进了我们 TM 房间的快速的召回的理解的研究是熟练地在其它地方考察了 1,我们将因此首先集中于 CD8+ T 房间的研究。我们将首先考察 CD8+ TM 房间能被产生的不同方法,由讨论这怎么在有免疫力的保护和病理的背景影响他们的功能的性质列在后面。然后,快速的召回能力将被讨论,与放在当前对机制被知道位于 TM 房间的这个唯一的性质下面的上的强调。 | Joanna R DiSpirito Hao Shen | 2010 | Cell Research2010，20，1： | 2 |
| 2 | Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy显示文摘High-speed high-resolution imaging of the whole-brain hemodynamics is critically important to facilitating neurovascular research.High imaging speed and image quality are crucial to visualizing real-time hemodynamics in complex brain vascular networks,and tracking fast pathophysiological activities at the microvessel level,which will enable advances in current queries in neurovascular and brain metabolism research,including stroke,dementia,and acute brain injury.Further,real-time imaging of oxygen saturation of hemoglobin(sO_(2))can capture fast-paced oxygen delivery dynamics,which is needed to solve pertinent questions in these fields and beyond.Here,we present a novel ultrafast functional photoacoustic microscopy(UFF-PAM)to image the whole-brain hemodynamics and oxygenation.UFF-PAM takes advantage of several key engineering innovations,including stimulated Raman scattering(SRS)based dual-wavelength laser excitation,water-immersible 12-facet-polygon scanner,high-sensitivity ultrasound transducer,and deep-learning-based image upsampling.A volumetric imaging rate of 2 Hz has been achieved over a field of view(FOV)of 11×7.5×1.5 mm^(3) with a high spatial resolution of~10 μm.Using the UFF-PAM system,we have demonstrated proof-of-concept studies on the mouse brains in response to systemic hypoxia,sodium nitroprusside,and stroke.We observed the mouse brain's fast morphological and functional changes over the entire cortex,including vasoconstriction,vasodilation,and deoxygenation.More interestingly,for the first time,with the whole-brain FOV and micro-vessel resolution,we captured the vasoconstriction and hypoxia simultaneously in the spreading depolarization(SD)wave.We expect the new imaging technology will provide a great potential for fundamental brain research under various pathological and physiological conditions. | Xiaoyi Zhu Qiang Huangl Anthony Dispirito Tri Vu Qiangzhou Rong Xiaorui Peng Huaxin Sheng Xiling Shen Qifa Zhou Laiming Jiang Ulrike Hoffmann Junjie Yao | 2022 | Light(Science & Applications)2022，11，6： | 2 |
| 3 | Methanobactin,a copper-acquisition compound from methane-oxidizing bacteria显示文摘 | Kim H J Graham D W DiSpirito A A | 2004 | Science2004，305，10： | 1 |
| 4 | Membrane-associated methane monooxygenase from Methylococcus capsulatus (Bath)显示文摘 | Zahn J A DiSpirito A A | 1996 | Am Soc Microbiol1996，178，4： | 1 |
| 5 | Life in the extreme:thermoacidophilic methanotrophy显示文摘 | Semrau JD Dispirito AA Murrell JC | | 0，，05： | 1 |
| 6 | Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARgamma显示文摘 | Wang F Mullican SE Dispirito JR | 2013 | Proc Natl Acad Sei USA2013，110，18： | 1 |
| 7 | In bacteria which grow in simple reductants,generation of proton gradient involnes extra cytoplasmic oxidation of substrate显示文摘 | Hooper A B DiSpirito A A | 1985 | Microbiol1985，，49： | 1 |
| 8 | Lipoatrophy and severemetabolic disturbance in mice with fat-specific deletion of PPAR7显示文摘 | Wang FF Mullican SE Dispirito JR | 2013 | Proc Nati Acad Sci2013，110，18： | 1 |
| 9 | Evaluation of succinic acid continuous and repeat-batch biofilm fermentation by Actinnobacillus succinogenes using plastic composite support bioreactors显示文摘 | Urbance S E Pometto A L DiSpirito A A | 2004 | Appl Microbiol Biotechnol2004，65，： | 1 |
| 10 | Membrane-associated methanemonooxygenase from methylococcus capsulatus bath显示文摘 | Zahn J A DiSpirito A A | 1996 | JBacteriol1996，178，4： | 1 |
| 11 | Correlation of human olfactory responses to airbone concentrations of malodorous volatile organic compounds emitted from swine effluent显示文摘 | Zahn J A Dispirito A A Do Y S | 2001 | J Environ Qual2001，30，： | 1 |
| 12 | Correlation of human olfactory responses to airborne concentrations of malodorous volatile organic compounds emitted from swine effluent显示文摘 | Zahn J A DiSpirito A A Do Y S | 2001 | Journol of Environmentol Quality2001，30，： | 1 |
| 13 | Evaluationof succinic acid continuous and repeat -batch biofilm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors 显示文摘 | Susan E Urbance Anthony L Pometto Alan A DiSpirito Yuksel Denli | 2004 | Biotechnological Products and Process Engineering Appl Microbiol Biotechnol2004，65，： | 1 |
| 14 | Evidence for a copper-dependent iron transport system in the marine,magnetotactic bacterium strain MV-1显示文摘 | Dubbels B L DiSpirito A A Morton J D | 2004 | Microbiology2004，150，： | 1 |
| 15 | Metha-nobactin ,a copper-acquisition compound from methane-oxidizing bacteria 显示文摘 | Kim H J Graham D W DiSpirito A A | 2004 | Science2004，305，5690： | 1 |
| 16 | Effect of nutrient and selective in-hibitor amendments on methane oxidation,nitrous oxide production,andkey gene presence and expression in landfill cover soils:Characterizationof the role of methanotrophs,nitrifiers,and denitrifiers显示文摘 | LEE S W IM J DISPIRITO A A | 2009 | Applied Mi-crobiology and Biotechnology2009，85，： | 1 |
| 17 | Evaluation of succinic acid continuous and repeat-batch biolm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors显示文摘 | URBANCE S E POMETTO A L DISPIRITO A A | 2004 | Appl Micro boil Biotechnol2004，，65： | 1 |
| 18 | Membrane-associated methane monooxygenase from Methyloeoecus eapsulatus (Bath) 显示文摘 | Zahn J A DiSpirito A A | 1996 | JBaet1996，178，4： | 1 |
| 19 | Methanobactin, a copper- acquisition compound from methaneoxidizing bacteria 显示文摘 | HJ Kim DW Graham AA Dispirito el al | 2004 | Science2004，305，： | 1 |
| 20 | Evaluation of succinic acid continuous and repeat-batch biofilm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors显示文摘 | Susan E. Urbance Anthony L. Pometto Alan A. DiSpirito Yuksel Denli | 2004 | Applied Microbiology and Biotechnology2004，，6： | 1 |
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