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| 1 | 睡眠呼吸暂停人群高血压患病率的多中心研究显示文摘目的调查我国睡眠呼吸暂停人群高血压患病情况和影响因素。方法纳入2004至2006年全国20家三甲医院呼吸内科门诊就诊的2297例患者,男:女为1310:211,均经过询问病史、体格检查和多导睡眠监测。统一使用中华医学会呼吸病学分会睡眠呼吸疾病学组编制的《睡眠呼吸暂停与高血压发病情况问卷调查表》对受试者进行问卷和规范的血压测量。应用 SPSS 11.0软件包进行数据分析,采用 X^2检验比较高血压患病率。结果呼吸暂停低通气指数(AHI)<5次/h 组(213例)的高血压患病率(23.5%)明显低于 AHI≥5次/h 组(2084例)的高血压患病率(49.3%);阻塞性睡眠呼吸暂停低通气综合征(OSAHS)人群的高血压患病率为56.2%(569/1012);有高血压家族史人群的高血压患病率为63.7%(450/706),明显高于无家族史者39.4%(627/1591)的患病率;AHI≥5次/h 组的高血压患病几率是 AHI<5次/h 组的3倍(OR=3.167,95%CI 为2.953~5.426,P<0.01);受试人群的高血压患病率随 AHI 增加而增加,自 AHI 16~20次/h 起患病率增高幅度明显加大,AHI 66~70次/h 以后呈下降趋势。经计算得出公式:高血压患病率=0.3199+0.0042×AHI;高血压患病的 OR 值=1.018+0.017×AHI,同时,受试者的高血压患病率随睡眠最低血氧饱和度的减低而明显增高,随嗜睡指数增高而明显增高。受试人群的 AHI 为独立于年龄、性别、体重指数和高血压家族史之外的高血压危险因素。结论睡眠呼吸暂停人群的高血压患病率明显高于无睡眠呼吸暂停人群,睡眠呼吸暂停与高血压患病率有密切的相关关系,是独立于年龄、体重指数和高血压家族史的高血压患病危险因素。 | Sleep Breathing Disorder Group of Respiratory Diseases Branch,Chinese Medical Association | 2007 | 中华结核和呼吸杂志2007，30，12： | 123 |
| 2 | A meta-analysis of oxidative stress markers in schizophrenia显示文摘Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent results.To evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy controls.This study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ patients.No significant effect size was found for the activities of GP and CAT in SCZ patients(P>0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 markers.The subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and SOD.The result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia. | ZHANG Ming1,2,ZHAO ZhongMing3,HE Lin1,2,4 & WAN ChunLing1,2 1 Bio-X Center,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200030,China 2 Institutes for Nutritional Sciences,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 3 Departments of Biomedical Informatics,Psychiatry,and Cancer Biology,Vanderbilt University Medical Center,Nashville,TN 37232,USA 4 Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China | 2010 | Science China(Life Sciences)2010，53，1： | 32 |
| 3 | Chinese expert consensus on programming deep brain stimulation for patients with Parkinson’s disease显示文摘Background:Deep Brain Stimulation(DBS)therapy for the treatment of Parkinson’s Disease(PD)is now a well-established option for some patients.Postoperative standardized programming processes can improve the level of postoperative management and programming,relieve symptoms and improve quality of life.Main body:In order to improve the quality of the programming,the experts on DBS and PD in neurology and neurosurgery in China reviewed the relevant literatures and combined their own experiences and developed this expert consensus on the programming of deep brain stimulation in patients with PD in China.Conclusion:This Chinese expert consensus on postoperative programming can standardize and improve postoperative management and programming of DBS for PD. | Shengdi Chen Guodong Gao Tao Feng Jianguo Zhang The Chinese Medical Association neurosurgery branch of functional neurosurgery group The Chinese Medical Association neurology branch of Parkinson’s disease,Movement disorders group The Chinese Physician Association neurosurgeon branch of functional neurosurgery expert committee The Chinese Physician Association neurologist branch of Parkinson’s disease and Movement disorders professional committee Chinese expert committee on Deep Brain Stimulation for Parkinson’s Disease | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 4 | Spinal processing of bee venom-induced pain and hyperalgesia显示文摘Subcutaneous injection of bee venom causes long-term neural activation and hypersensitization in the dorsal horn of the spinal cord,which contributes to the development and maintenance of various pain-related behaviors.The unique behavioral 'phenotypes' of nociception and hypersensitivity identified in the rodent bee venom test are believed to reflect a complex pathological state of inflammatory pain and might be appropriate to the study of phenotype-based mechanisms of pain and hyperalgesia.In this review,the spinal processing of the bee venom-induced different 'phenotypes' of pain and hyperalgesia will be described.The accumulative electrophysiological,pharmacological,and behavioral data strongly suggest that different 'phenotypes' of pain and hyperalgesia are mediated by different spinal signaling pathways.Unraveling the phenotype-based mechanisms of pain might be useful in development of novel therapeutic drugs against complex clinic pathological pain. | Jun CHEN Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,the Fourth Military Medical University,Xi’an 710038,China Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China | 2008 | 生理学报2008，60，5： | 3 |
| 5 | Recommendationes on stroke prevention,iagnosis ,nd therapy显示文摘 | Report of the WHO Task Force on Stroke and other Cetebrovascular Disordes | 1989 | Stroke1989，0，10： | 2 |
| 6 | A systems approach to immediate evaluation and management of hyperacute stroke : experience at eight centers and implications for community practice and patient care显示文摘 | The National Institute of Neurological Disorders and Stroke (NINDS) rt - PA Stroke Study Group | 1997 | Stroke1997，28，8： | 1 |
| 7 | 2nd edition 显示文摘 | The International Classification of Headache Disorder | 2004 | Cephalalgia2004，24，1： | 1 |
| 8 | Recommendations on stroke prevention, diagnosis and therapy显示文摘 | Report of the WHO task force on stroke and other cerebrovasular disorders | 1989 | Stroke1989，20，10： | 1 |
| 9 | Ultrasonography screening in 96, 278 unselected employees 显示文摘 | Reiners C Wegscheider K Schicha H Prevalence of thyroid disorders in the working population of Germany | 2004 | Thyroid2004，14，11： | 1 |
| 10 | Tissue plasminogen activator for acute ischemic stroke显示文摘 | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Engl J Med1995，333，： | 1 |
| 11 | Recombinant tissue plasminogen activator for minor strokes:the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience显示文摘 | National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group | | 0，，： | 1 |
| 12 | Practice guideline for the treatment of patients with eating disorders(revision)显示文摘 | American psychiatric association work group on eating disorders | 2000 | Am J Psychiatry2000，157，1： | 1 |
| 13 | Tissue plasminogen activator for acute ischemic stroke显示文摘 | National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Engl J Med1995，333，： | 1 |
| 14 | The report of an American Academy of Sleep Medicine Task Force显示文摘 | Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research | 1999 | Sleep1999，22，5： | 1 |
| 15 | Tissue plasminogen activator for acute ischlemic stroke 显示文摘 | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Eng J Med1995，333，24： | 1 |
| 16 | Tissue plasminogen activator for acute ishemia stroke显示文摘 | The National Instiute of Neurological Disorders and Stroke Study Group | 2003 | New Engl J Med2003，333，24： | 1 |
| 17 | EEG arousals: scoring rules and examples:a preliminary report from the sleep Discords Atlas Task Foce of the American Sleep Discards Association显示文摘 | American Sleep Disorders Association | 1992 | Sleep1992，15，2： | 1 |
| 18 | Tissue plasminogen activator for acute ischemic stroke 显示文摘 | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Engl J Med1995，333，24： | 1 |
| 19 | Tissue plasminogen activator for acute ischemic stroke显示文摘 | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Engl J Med1995，333，24： | 1 |
| 20 | Tissue plasminogen activator for acute ischemic stroke显示文摘 | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group | 1995 | N Engl J Med1995，333，： | 1 |
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