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| 1 | Simulation Researches on Influence of Different Axial Magnetic Fields on Anode Activity in High-current Vacuum Arcs显示文摘纵向磁场对阳极活动的控制效果对于大电流真空电弧成功开断十分关键。采用建模仿真的方法,分析不同纵向磁场强度对阳极活动的影响。基于大电流真空电弧模型,仿真得到不同纵向磁场强度下输入阳极的能流密度分布,并以此作为阳极活动模型的边界条件,得到不同磁场强度下的阳极熔化、蒸发情况。仿真结果表明:对于工频电流(50Hz)电弧,阳极温度的最大值出现7ms时刻附近;随着纵向磁场的增大,阳极表面温度、饱和蒸汽压、阳极蒸汽流量都相应减小;随着纵向磁场的增大,熔化半径增大,但是熔化深度减小,改善了阳极的烧蚀情况。 | WANG Lijun JIA Shenli CHEN Bin ZHOU Xin YANG Dingge SHI Zongqian | 2012 | 中国电机工程学报2012，32，13： | 8 |
| 2 | Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women显示文摘Objective:There are many hereditary breast cancer patients in China,and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives.However,the magnitude of breast cancer risks related to multiple breast cancer susceptibility genes are largely unknown in Chinese women.Methods:We screened pathogenic variants in 15 established or potential breast cancer susceptibility genes from 8,067 consecutive Chinese female breast cancer patients and 13,129 Chinese cancer-free female controls.These breast cancer patients were unselected for age at diagnosis or family history.Results:We found that pathogenic variants in TP53[odds ratio(OR):16.9,95%confidence interval(CI):5.2–55.2];BRCA2(OR:10.4,95%CI:7.6–14.2);BRCA1(OR:9.7,95%CI:6.3–14.8);and PALB2(OR:5.2,95%CI:3.0–8.8)were associated with a high risk of breast cancer.ATM,BARD1,CHEK2,and RAD51D were associated with a moderate risk of breast cancer with ORs ranging from 2-fold to 4-fold.In contrast,pathogenic variants of NBN,RAD50,BRIP1,and RAD51C were not associated with increased risk of breast cancer in Chinese women.The pathogenic variants of PTEN,CDH1,and STK11 were very rare,so they had a limited contribution to Chinese breast cancer.Patients with pathogenic variants of TP53,BRCA1,BRCA2,and PALB2 more often had earlyonset breast cancer,bilateral breast cancer,and a family history of breast cancer and/or any cancer.Conclusions:This study provided breast cancer risk assessment data for multiple genes in Chinese women,which is useful for genetic testing and clinical management of Chinese hereditary breast cancer. | Fenfen Fu Dongjie Zhang Li Hu Senthil Sundaram Dingge Ying Ying Zhang Shuna Fu Juan Zhang Lu Yao Ye Xu Yuntao Xie | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 3 | Preparing of a high speed bistable electromagnetic RF MEMS switch显示文摘 | ZHANG Y H DINGG F SUN X F | 2007 | Sens Actuators A2007，134，2： | 1 |
| 4 | Peroxisome proliferator-activated receptor δ activates fatty acid oxidation incultured neonatal and adult cardiomyocytes显示文摘 | Cheng L DingG QinQ | | 0，，： | 1 |
| 5 | Mod- elling and simulation of anode activity in high-current vacuum arc 显示文摘 | WANG Lijun JIA Shenli YANG Dingge | 2009 | Journal of Physics D: Applied Phys- ics2009，42，14： | 1 |
| 6 | Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related peptide driven by dorsal root reflexes显示文摘 | Dingge Li Yong Ren Xijin Xu | 2008 | Pain2008，9，12： | 1 |
| 7 | Minocycline inhibits the enhancement of antidromic primary afferent stimulation-evoked vasodilation following intradermal capsaicin injection显示文摘 | Kerui Gong Yue Yue Xiaoju Zou Dingge Li Qing Lin | 2010 | Neuroscience Letters2010，，2： | 1 |
| 8 | In- vestigation of the swirl flow on anode surface in high- current vacuum arcs 显示文摘 | JIA Shenli YANG Dingge WANG Lijun | 2012 | Journal of Applied Physics2012，111，04： | 1 |
| 9 | Sensitization of primary affer- ent nocieeptors induced by intradermal capsaicin involves the periph- eral release of calcitonin gene-related peptide driven by dorsal root reflexes 显示文摘 | Dingge Li Yong Ren Xijin Xu | 2008 | Pain2008，9，12： | 1 |
| 10 | Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator'activated receptor gamma 显示文摘 | DINGg QIN Q HE N | 2007 | l Mol Cell Cardio12007，43，1： | 1 |
| 11 | TriggeringthecontinuousgrowthofgraphenetowardmillimeterGsizedgrains显示文摘 | WuT DingG ShenH etal | 2013 | AdGvancedFunctionalMaterials2013，23，2： | 1 |
| 12 | Angiomyofibroblastomalike tumorof the scrotum: A case report and literature review显示文摘 | DINGG YU Y JIN M | 2014 | Oncol Letters2014，7，2： | 1 |
| 13 | Spatial-temporalop?portunity detection in spectrum-heterogeneous cognitive ra?dio networks: Two-dimensional sensing显示文摘 | WuQ DingG WangJ YaoYD | 2013 | IEEE Trans?actions on Wireless communications2013，12，2： | 1 |
| 14 | SysZNF:theC2H2zincfingergenedatabase显示文摘 | DingG LorenzP KreutzerM etal | 2009 | NucleicAcidsRe-search2009，，： | 1 |
| 15 | Allogeneicperiodontalligamentstemcelltherapyforperiodontitisinswine显示文摘 | DingG LiuY WangW etal | 2010 | StemCells2010，28，10： | 1 |
| 16 | Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related peptide driven by dorsal root reflexes显示文摘 | Dingge L Yong R Xi J X | 2008 | J Pain2008，9，12： | 1 |
| 17 | Effective induction of immune tolerance by portal venous infusion with IL-IO gene-modified immature dendritic cells leading to prolongation of allograft survival显示文摘Dendritic cells (DC) not only initiate T cell responses, but are also involved in the induction of tolerance. The functional properties of DC are strictly dependent on their state of maturation. It has been shown that immature DC can induce immune tolerance and prolong allograft survival. Interleukin-10 (IL-10) is an important immunosuppressive eytokine which inhibits maturation and function of DC. In order to improve the tolerogenieity of DC, we and others showed that adenovirus vectors can effectively mediate IL 10 genetic modification of DC, and IL-10 genetic modification can inhibit MHC Ⅱ, B7.2, | ZhangM WangQ LiuY SunY, DingG FuZ MinZ ZhuY CaoX | 2005 | 第二军医大学学报2005，26，5： | 0 |
| 18 | In-depth cDNA Library Sequencing Provides Quantitative Gene Expression Profiling in Cancer Biomarker Discovery显示文摘Quantitative gene expression analysis plays an important role in identifying differentially expressed genes in various pathological states, gene expression regulation and co-regulation, shedding light on gene functions. Although microarray is widely used as a powerful tool in this regard, it is suboptimal quantitatively and unable to detect unknown gene variants. Here we demonstrated effective detection of differential expression and co-regulation of certain genes by expressed sequence tag analysis using a selected subset of cDNA libraries. We discussed the issues of sequencing depth and library preparation, and propose that increased sequencing depth and improved preparation procedures may allow detection of many expression features for less abundant gene variants. With the reduction of sequencing cost and the emerging of new generation sequencing technology, in-depth sequencing of cDNA pools or libraries may represent a better and powerful tool in gene expression profiling and cancer biomarker detection. We also propose using sequence-specific subtraction to remove hundreds of the most abundant housekeeping genes to increase sequencing depth without affecting relative expression ratio of other genes, as transcripts from as few as 300 most abundantly expressed genes constitute about 20% of the total transcriptome. In-depth sequencing also represents a unique advantage of detecting unknown forms of transcripts, such as alternative splicing variants, fusion genes, and regulatory RNAs, as well as detecting mutations and polymorphisms that may play important roles in disease pathogenesis. | Wanling Yang Dingge Ying Yu-Lung Lau | 2009 | Genomics, Proteomics & Bioinformatics2009，7，1： | 0 |
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