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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Understanding the medial ulnar collateral ligament of the elbow: Review of native ligament anatomy and function显示文摘The medial ulnar collateral ligament complex of the elbow, which is comprised of the anterior bundle [AB, more formally referred to as the medial ulnar collateral ligament(MUCL)], posterior(PB), and transverse ligament, is commonly injured in overhead throwing athletes. Attenuation or rupture of the ligament results in valgus instability with variable clinical presentations. The AB or MUCL is the strongest component of the ligamentous complex and the primary restraint to valgus stress. It is also composed of two separate bands(anterior and posterior) that provide reciprocal function with the anterior band tight in extension, and the posterior band tight in flexion. In individuals who fail co-mprehensive non-operative treatment, surgical repair or reconstruction of the MUCL is commonly required to restore elbow function and stability. A comprehensive understanding of the anatomy and biomechanical properties of the MUCL is imperative to optimize reconstructive efforts, and to enhance clinical and radiographic outcomes. Our understanding of the native anatomy and biomechanics of the MUCL has evolved over time. The precise locations of the origin and insertion footprint centers guide surgeons in proper graft placement with relation to bony anatomic landmarks. In recent studies, the ulnar insertion of the MUCL is described as larger than previously thought, with the center of the footprint at varying distances relative to the ulnar ridge, joint line, or sublime tubercle. The purpose of this review is to consolidate and summarize the existing literature regarding the native anatomy, biomechanical, and clinical significance of the entire medial ulnar collateral ligament complex, including the MUCL(AB), PB, and transverse ligament. | Joshua R Labott William R Aibinder Joshua S Dines Christopher L Camp | 2018 | World Journal of Orthopedics2018，9，6： | 4 |
| 3 | Effect of bone loss in anterior shoulder instability显示文摘Anterior shoulder instability with bone loss can be a difficult problem to treat. It usually involves a component of either glenoid deficiency or a Hill-Sachs lesion. Recent data shows that soft tissue procedures alone are typically not adequate to provide stability to the shoulder. As such, numerous surgical procedures have been described to directly address these bony deficits. For glenoid defects, coracoid transfer and iliac crest bone block procedures are popular and effective. For humeral head defects, both remplissage and osteochondral allografts have decreased the rates ofrecurrent instability. Our review provides an overview of current literature addressing these treatment options and others for addressing bone loss complicating anterior glenohumeral instability. | Grant H Garcia Joseph N Liu David M Dines Joshua S Dines | 2015 | World Journal of Orthopedics2015，6，5： | 3 |
| 4 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 5 | Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction显示文摘While most patients with an anterior cruciate ligament(ACL) injury indicate satisfaction with surgical intervention, a significant proportion still do not return to pre-injury level of function or sport. Psychiatric comorbidities, such as depression, have recently been associated with poor clinical outcomes after ACL reconstruction(ACLR). To date, no article has yet examined how depression affects ACLR outcomes and how potential screening and intervention for psychological distress may affect postoperative activity level. The purpose of this review is to delineate potential relationships between depression and ACLR outcome, discuss clinical implications and identify future directions for research. | Hao-Hua Wu Max Liu Joshua S Dines John D Kelly Grant H Garcia | 2016 | World Journal of Orthopedics2016，7，11： | 2 |
| 6 | THE STRESS-STRAIN-RESISTANCE RELATIONS IN Fe-Mn-Si ALLOYS显示文摘The stress-strain-resistance relations of the Fe-Mn-Si alloys with different Si content have been investigated by measuring strain (ε) and resistance (△ R/R) upon tension synchronously. The results show that the strum induced γ→ε martensitic transfor- mation increases the strain sensitivity coeffcient of resistance (K) for the Fe-Mn-Si alloys in plastic region. There is a critical strum where dσ/dε becomes a constant value. Si increases the critical strum. A correlation between the critical strain and shape memory effect (SME) in the Fe-Mn-Si alloys is suggested. | X. Lu, Z.X. Qin, Y.S. Zhang, B.Z. Dine and Z.Q. Hu ( Department of Materials Science & Engineering, Dalian Railway Institute, Dalian 116028, China State Key Laboratory for RSA, Institute of Metal Research, The Chinese Academy of Science, Shenyang 110015, | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，5： | 2 |
| 7 | Effect of different enteral nutrients on bacterial translocation in experimental obstructive jaundice 显示文摘 | Kuru B Dine S Altinok G | 2004 | Eur Surg Res2004，36，1： | 1 |
| 8 | The Effects of the Social Structure of Digital Networks on Viral Marketing Performance显示文摘 | Mauro Bampo Michael T. Ewing Dineli R. Mather David Stewart Mark Wallace | 2008 | Information Systems Research2008，，3： | 1 |
| 9 | Aminimally invasive approach for plate fixation of the proximal humerus显示文摘 | Gardner M J Griffith M H Dines J S | 2004 | Bull Hosp Jt Dis2004，62，12： | 1 |
| 10 | Endoscopically assisted minimally invasive microvascular decompression of hemifacial spasm 显示文摘 | Badr E1 Dine M El Garem H F Talaat A M | 2002 | Otol Neurotol2002，23，2： | 1 |
| 11 | Modular shoulder hemi arthroplasty for acute fractures 显示文摘 | Dines DM Warren RF | 1994 | Clin Orthop1994，307，： | 1 |
| 12 | Local anesthetics as anti- microbial agents 显示文摘 | Johnson SM Saint BE Dine AP | 2008 | Surg Infect : Larchmt2008，9，2： | 1 |
| 13 | Compatibilityof nitroglycerin, diazepam and chlorpromazine with a newmultilayer material for infusion containers 显示文摘 | Kambia NK Dine T Dupin-Spriet T | 2005 | J PharmBiomedAnal2005，37，： | 1 |
| 14 | Minimally invasive ap- proach for plate fixation of the proximal humerus显示文摘 | Gardner M J Gaiffith M H Dines J S | 2012 | Bull Hosp Jt Dis2012，62，11： | 1 |
| 15 | Comparison of IOPmeasurement by ocular response analyzer, dynamic contour,Goldmann applanation and noncontact tonometry显示文摘 | Oncel B Dine U Orge F | 2009 | EurJOphthalmol2009，19，6： | 1 |
| 16 | Minimally invasive approach for plate fixation of the proximal humerus 显示文摘 | Gardner M J Gaiffith M H Dines J S | 2004 | Bull Hosp Jt Dis2004，62，： | 1 |
| 17 | Tendon gene therapy modulates the local repair environment in the shoulder显示文摘 | Uggen JC Dines J Uggen CW | 2005 | J Am Osteopath Assoc2005，105，1： | 1 |
| 18 | Toxic myocarditis: report of a case arising from ingestion of liquid plastic catalyst 显示文摘 | Dines DE Shipman K | 1962 | Angiology1962，13，： | 1 |
| 19 | Ab Initio and Density Functional Study of the Resonance Raman Spectra of Methyl Red,Ethyl Red and Their Protonated Derivatives显示文摘 | BISSET A DINES T J | 1998 | Journal of Raman Spectroscopy1998，29，： | 1 |
| 20 | Malignant pulmonary neoplasms predisposing to spontaneous pneumothorax 显示文摘 | DINES D E CORTESE D A BRENNAN M D | 1973 | Mayo Clin Proc1973，48，7： | 1 |
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