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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | Pentoxifylline improves blood flow to both testes in testicular torsion 显示文摘 | Savas C Dindar H Aras T | 2002 | Int Urol Nephrol2002，33，1： | 1 |
| 3 | Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei显示文摘 | Pascoalino B Dindar G Vieira-da-Rocha J P | 2014 | Nucleic Acids Res2014，42，5： | 1 |
| 4 | An evaluation of chil- dren with Kawasaki disease in Istanbul: A retrospective follow-up study显示文摘 | Kayiran SM Dindar A Gurakan B | 2010 | Clinics(Sao Paulo)2010，65，12： | 1 |
| 5 | Solar photocatalytic disinfection of a group of bacteria and fungi aqueous suspensions with TiO2, ZnO and Sahara desert dust 显示文摘 | Seven O Dindar B Aydemir | 2004 | Journal of Photochemistry and Photobiology A: Chemistry2004，165，13： | 1 |
| 6 | Mean platelet volume is associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus显示文摘 | Dindar S Cinemre H Sengul E | 2013 | West Indian Med J2013，62，6： | 1 |
| 7 | Necrosis of the donor site after hair restoration with follicular unit extraction ( FUE ) : a case report 显示文摘 | Karacal N Uraloglu M Dindar T | 2012 | J Plast Reconstr Aesthet Surg2012，65，4： | 1 |
| 8 | Pentoxifylline improves blood flow to both testes in testicular torsion显示文摘 | Savas C Dindar H Aras T | 2002 | Int Urol Nephrol2002，33，1： | 1 |
| 9 | Mean platelet volume is associatedwith glycaemic control and retinopathy in patients with type 2 diabetesmellitus显示文摘 | Dindar S Cinemre H Engul E | 2013 | West Indian Med J2013，62，6： | 1 |
| 10 | An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study显示文摘 | Kayiran SM Dindar A Gurakan B | 2010 | Clinics (Sao Paulo)2010，65，12： | 1 |
| 11 | Screening of Turki women for postpartum depression within the first postpartum year: the risk profile of a community sarrle 显示文摘 | Dindar I Erdogan S | 2007 | Public Health Nurs2007，24，2： | 1 |
| 12 | Usefulness of oral dipyridamole therapy for angiographie slow coronary artery flow显示文摘 | Kurtoglu N Akeay A Dindar I | 2001 | Am J Car- dial2001，87，： | 1 |
| 13 | Sublingual isosorbide dinitrate-stimulated tilt test for diagnosis of vasovagal syncope in children and adolescents显示文摘 | Dindar A Cetin B Ertugrul T | | 0，，03： | 1 |
| 14 | Lisefulness of oral dipyridamole cherapy for singiognaphic slow coronary antery flow 显示文摘 | Kurtoplu N Akeary A Dindar I | 2001 | Am J Cardiol2001，87，： | 1 |
| 15 | Usefulness of oral dipyridamole therapy for angiographic slow coronary artery flow 显示文摘 | KURTOGLU N AKCAY A DINDAR I | 2001 | Am J Cardiol2001，87，6： | 1 |
| 16 | Unusual photoreactivity of zinc oxide irradiated by concentrated sunlight显示文摘 | DINDAR B ICLI S | 2001 | J Photochem Photobiol A:Chem2001，140，： | 1 |
| 17 | Unusual photoreactivity of zinc oxide irradiated byconcentrated sunlight显示文摘 | DINDAR B ICLI S | 2001 | Photobioly Chem2001，，140： | 1 |
| 18 | Usefulness of oral dipyridamole therapy for angiographic slow coronary artery flow显示文摘 | Kurtoglu N Akcay A Dindar I | | American Journal of Cardiology0，，： | 1 |
| 19 | An evaluation of children with Kawasaki disease in Istanbul:a retrospective follow-up study显示文摘 | Kayiran S M DindaR A Gurakan B | 2010 | Clinics(Sao Paulo)2010，65，12： | 1 |
| 20 | Effect of a sulfonated azo dye and sulfanilic acid on nitrogen transformation processes in soil显示文摘 | TOPAC F O DINDAR E SELNUR U | 2009 | J Hazard Mater2009，170，： | 1 |
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