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| 1 | Gene polymorphisms associated with functional dyspepsia显示文摘Functional dyspepsia(FD) is a constellation of functional upper abdominal complaints with poorly elucidated pathophysiology. However, there is increasing evidence that susceptibility to FD is influenced by hereditary factors. Genetic association studies in FD have examined genotypes related to gastrointestinal motility or sensation, as well as those related to inflammation or immune response. G-protein b3 subunit gene polymorphisms were first reported as being associated with FD. Thereafter, several gene polymorphisms including serotonin transporter promoter, interlukin-17 F, migration inhibitory factor, cholecystocynine-1 intron 1, cyclooxygenase-1, catechol-o-methyltransferase, transient receptor potential vanilloid 1 receptor, regulated upon activation normal T cell expressed and secreted, p22 PHOX, Toll like receptor 2, SCN10 A, CD14 and adrenoreceptors have been investigated in relation to FD; however, the results are contradictory. Several limitations underscore the value of current studies. Among others, inconsistencies in the definitions of FD and controls, subject composition differences regarding FD subtypes, inadequate samples, geographical and ethnical differences, as well as unadjusted environmental factors. Further well-designed studies are necessary to determine how targeted genes polymorphisms, influence the clinical manifestations and potentially the therapeutic response in FD. | Anastasia Kourikou George P Karamanolis George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Gastroenterology2015，21，25： | 8 |
| 2 | Virtual reality simulators for gastrointestinal endoscopy training显示文摘The use of simulators as educational tools for medical procedures is spreading rapidly and many efforts have been made for their implementation in gastrointestinal endoscopy training. Endoscopy simulation training has been suggested for ascertaining patient safety while positively influencing the trainees' learning curve. Virtual simulators are the most promising tool among all available types of simulators. These integrated modalities offer a human-like endoscopy experience by combining virtual images of the gastrointestinal tract and haptic realism with using a customized endoscope. From their first steps in the 1980s until today, research involving virtual endoscopic simulators can be divided in two categories: investigation of the impact of virtual simulator training in acquiring endoscopy skills and measuring competence. Emphasis should also be given to the financial impact of their implementation in endoscopy, including the cost of these state-of-theart simulators and the potential economic benefits from their usage. Advances in technology will contribute to the upgrade of existing models and the development of new ones; while further research should be carried out to discover new fields of application. | Konstantinos Triantafyllou Lazaros Dimitrios Lazaridis George D Dimitriadis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 7 |
| 3 | Insulin action in muscle and adipose tissue in type 2 diabetes:The significance of blood flow显示文摘Under normal metabolic conditions insulin stimulates microvascular perfusion(capillary recruitment) of skeletal muscle and subcutaneous adipose tissue and thus increases blood flow mainly after meal ingestion or physical exercise.This helps the delivery of insulinitself but also that of substrates and of other signalling molecules to multiple tissues beds and facilitates glucose disposal and lipid kinetics.This effect is impaired in insulin resistance and type 2 diabetes early in the development of metabolic dysregulation and reflects early-onset endothelial dysfunction.Failure of insulin to increase muscle and adipose tissue blood flow results in decreased glucose handling.In fat depots,a blunted postprandial blood flow response will result in an insufficient suppression of lipolysis and an increased spill over of fatty acids in the circulation,leading to a more pronounced insulin resistant state in skeletal muscle.This defect in blood flow response is apparent even in the prediabetic state,implying that it is a facet of insulin resistance and exists long before overt hyperglycaemia develops.The following review intends to summarize the contribution of blood flow impairment to the development of the atherogenic dysglycemia and dyslipidaemia. | Vaia Lambadiari Konstantinos Triantafyllou George D Dimitriadis | 2015 | World Journal of Diabetes2015，6，4： | 6 |
| 4 | Improved bowel preparation increases polyp detection and unmasks significant polyp miss rate显示文摘AIM: To retrospectively compare previous-day vs splitdose preparation in terms of bowel cleanliness and polyp detection in patients referred for polypectomy. METHODS: Fifty patients underwent two colonoscopies: one diagnostic in a private clinic and a second for polypectomy in a University Hospital. The latter procedures were performed within 12 wk of the index ones. Examinations were accomplished by two experienced endoscopists, different in each facility. Twenty-seven patients underwent screening/surveillance colonoscopy, while the rest were symptomatic. Previous day bowel preparation was utilized initially and splitdose for polypectomy. Colon cleansing was evaluated using the Aronchick scale. We measured the number of detected polyps, and the polyp miss rates per-polyp.RESULTS: Excellent/good preparation was reported in 38 cases with previous-day preparation(76%) vs 46 with split-dose(92%), respectively(P = 0.03). One hundred and twenty-six polyps were detected initially and 169 subsequently(P < 0.0001); 88 vs 126 polyps were diminutive(P < 0.0001), 25 vs 29 small(P = 0.048) and 13 vs 14 equal or larger than 10 mm. The miss rates for total, diminutive, small and large polyps were 25.4%, 30.1%, 13.7% and 6.6%, respectively. Multivariate analysis revealed that split-dose preparation was significantly associated(OR, P) with increased number of polyps detected overall(0.869, P < 0.001), in the right(0.418, P = 0.008) and in the left colon(0.452, P = 0.02). CONCLUSION: Split-dose preparation improved colon cleansing, enhanced polyp detection and unmasked significant polyp miss rates. | Ioannis S Papanikolaou Athanasios D Sioulas Nektarios Magdalinos Iosif Beintaris Lazaros-Dimitrios Lazaridis Dimitrios Polymeros Chrysoula Malli George D Dimitriadis Konstantinos Triantafyllou | 2015 | World Journal of Clinical Cases2015，3，10： | 4 |
| 5 | Myocardial and aortic stiffening in the early course of primary aldosteronism 显示文摘 | Tsioufis C Tsiachris D Dimitriadis K | 2008 | Clin Cardiol2008，31，9： | 1 |
| 6 | Eosinophilic gas- troenteritis complicated with perforation and intussusception in a neonate显示文摘 | Siahanidou T Mandyla H Dimitriadis D | 2001 | J Pediatr Gastroenterol Nutr2001，32，： | 1 |
| 7 | Relation of microalbuminuria to adiponectin and augmented C-reactive protein levels in men with essential hypertension显示文摘 | Dimitriadis K Chatzis D | 2005 | Am J Cardiol2005，96，： | 1 |
| 8 | Opti- mization of the sulforhodamine B colorimetric assay 显示文摘 | Papazisis K T Geromichalos G D Dimitriadis K A | 1997 | Im munological Methods1997，208，： | 1 |
| 9 | Eptifibatide-induced acute profound thrombocytopenia:a case report显示文摘 | Graidis C Golias C Dimitriadis D | 2014 | BMC Res Notes2014，7，7： | 1 |
| 10 | Relation of microalbuminuria to adiponectin and aug-mented C-reactive protein levels in men with essential hypertension显示文摘 | TSIOUFIS C DIMITRIADIS K CHATZIS D | 2005 | Am J Cardiol2005，96，： | 1 |
| 11 | Progressive neuromuscular planovalgusfoot deformity treated with a modified extra-articular subtalar fu-sion显示文摘 | Vlachou M Dimitriadis D | 2009 | Foot Ankle Int2009，7，： | 1 |
| 12 | A on the effects of fil-terbank design and energy computation on robust speech rec-ognition 显示文摘 | DIMITRIADIS D M POTAMIANOS P | 2011 | IEEE Transactions on Audio Speech and Lan-guage Processing2011，19，6： | 1 |
| 13 | Robust AM-FM festures for speech recognition显示文摘 | Dimitriadis D V Maragos P Potamianos P | 2005 | IEEE Signal Processing Letters2005，12，9： | 1 |
| 14 | Thyroid honnone excess and glucose intolerance 显示文摘 | Dimitriadis G D Raptis S A | 2001 | Exp Clin Endocrinol Diabetes2001，109，2： | 1 |
| 15 | Behaviaural consequences of perceived service quality:An exploratory study in the context of private fitness clubsin Greece 显示文摘 | Alexandris K Dimitriadis D Kasiara A | 2001 | European Sport Management Quarterly2001，，1： | 1 |
| 16 | Comparative study of Cd( II ) and Cr(VI) biosorption on staphylococcus xylosus and pseudomonas sp in single and binary mixtures显示文摘 | Ziagova M Dimitriadis G Aslani dou D | 2007 | Bioresource Technology2007，98，15： | 1 |
| 17 | Relation of microalbuminuria to adiponectin and augmented C-reactive protein levels in men with essential hypertension 显示文摘 | Tsioufis C Dimitriadis K Chatzis D | 2005 | AM J Cardiol2005，96，7： | 1 |
| 18 | Eosinophilic gas- troenteritis complicated with perforation and intussusception in a neo- nate显示文摘 | SIAHANIDOU T MANDYLA H DIMITRIADIS D | 2001 | J Pediatr Gastroenterol Nutr2001，32，： | 1 |
| 19 | Myocardial and aortic stiffening in the early course of primary aldosteronism显示文摘 | Tsioufis C Tsiachris D Dimitriadis K | 2008 | Clin Cardiol2008，31，9： | 1 |
| 20 | Relation of microalbuminuria to ad- iponectin and augmented C-reactive protein levels in men with essential hyper- tension显示文摘 | Tsioufis C Dimitriadis K Chatzis D | 2005 | Am J Cardiol2005，96，： | 1 |
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