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| 1 | Medicinal mushrooms in supportive cancer therapies:an approach to anti-cancer effects and putative mechanisms of action显示文摘Medicinal mushrooms have been valued as natural sources of bioactive compounds since times immemorial and have been recognized as potential immunomodulating and anti-cancer agents.Their consumption has consistently been shown to have beneficial effects on human health.Cancer is a generic term for several types of diseases that can be chronic and are responsible for a large number of deaths worldwide.Although there has been considerable progress in modern cancer therapy research,difficulties in understanding the molecular behavior of various types of cancers and the numerous side effects experienced by patients from treatments means that this whole subject area is still problematic.Thus,biological immunotherapy using natural bioactive compounds as supportive treatments in conventional cancer therapies has become in vogue.Bioactive metabolites isolated from medicinal mushrooms have shown potential successes in cancer treatment as biological immunotherapeutic agents that stimulate the immune system against cancer cells.They also act as an effective source of anti-cancer agents,capable of interfering with cellular signal transduction pathways linked to cancer development and progression.In this review we compile available data on the characteristics of medicinal mushrooms that appear to be particularly effective as biological immunotherapeutic agents.Major consideration is given to biological constituents and the putative mechanisms of action by which bioactive compounds act on the human body.Consideration is also given to the benefits that have been claimed for the use of mushrooms in treating cancer and the future prospects of using medicinal mushrooms as potent supportive candidate bioagents for treatment of cancers is discussed. | Dilani D.De Silva Sylvie Rapior Françoise Fons Ali H.Bahkali Kevin D.Hyde | 2012 | Fungal Diversity2012，，4： | 5 |
| 2 | Medicinal mushrooms in prevention and control of diabetes mellitus显示文摘Diabetes mellitus is a life-threatening chronic metabolic disease caused by lack of insulin and/or insulin dysfunction,characterized by high levels of glucose in the blood(hyperglycemia).Millions worldwide suffer from diabetes and its complications.Significantly,it has been recognized that type 2 diabetes is an important preventable disease and can be avoided or delayed by lifestyle intervention.Presently,there are many chemical and biochemical hypoglycemic agents(synthetic drugs),that are used in treating diabetes and are effective in controlling hyperglycemia.However,as they may have harmful side-effects and fail to significantly alter the course of diabetic complications,natural anti-diabetic drugs from medicinal plants have attracted a great deal of attention.Medicinal mushrooms have been valued as a traditional source of natural bioactive compounds over many centuries and have been targeted as potential hypoglycemic and anti-diabetic agents.Bioactive metabolites including polysaccharides,proteins,dietary fibres,and many other biomolecules isolated from medicinal mushrooms and their cultured mycelia have been shown to be successful in diabetes treatment as biological antihyperglycemic agents.In this review we discuss the biological nature of diabetes and,in particular,explore some promising mushrooms that have experimental anti-diabetic properties,preventing or reducing the development of diabetes mellitus.The importance of medicinal mushrooms as agents of medical nutrition therapy and how their metabolites can be used as supportive candidates for prevention and control of diabetes is explored.Future prospects for this field of study and the difficulties and constraints that might affect the development of rational drug products from medicinal mushrooms are discussed. | Dilani D.De Silva Sylvie Rapior Kevin D.Hyde Ali H.Bahkali | 2012 | Fungal Diversity2012，，5： | 4 |
| 3 | Application of integrated quality management systems to promote CI and learning in R&D organisations 显示文摘 | Dilani Jayawarna Alan W Pearson | 2003 | International Journal of Technology Management2003，，8： | 1 |
| 4 | Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry显示文摘Exploration of natural sources for novel bioactive compounds has been an emerging field of medicine over the past decades,providing drugs or lead compounds of considerable therapeutic potential.This research has provided exciting evidence on the isolation of microbe-derived metabolites having prospective biological activities.Mushrooms have been valued as traditional sources of natural bioactive compounds for many centuries and have been targeted as promising therapeutic agents.Many novel biologically active compounds have been reported as a result of research on medicinal mushrooms.In this review,we compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.The main emphasis is on their anti-Alzheimer,antidiabetic,anti-malarial,anti-microbial,anti-oxidant,antitumor,anti-viral and hypocholesterolemic activities which are important medicinal targets in terms of drug discovery today.Moreover,the reader’s attention is brought to focus on mushroom products and food supplements available in the market with claimed biological activities and potential human health benefits. | Dilani D.De Silva Sylvie Rapior Enge Sudarman Marc Stadler Jianchu Xu S.Aisyah Alias Kevin D.Hyde | 2013 | Fungal Diversity2013，，5： | 1 |
| 5 | Investigating the social capital and resource acquisition of entrepre?neurs residing in deprived areas of England显示文摘 | Robert L Heinz T Dilani J | 2011 | Envi?ronment and Planning C: Government and Policy2011，29，6： | 1 |
| 6 | Application of integrated quality management systems to promote CI and learning in R & D organizations 显示文摘 | Dilani Jayawarna Alan W Pearson | 2003 | International Journal of Technology Management2003，26，8： | 1 |
| 7 | Definition of Histopathologic Changes in Gastroesophageal Reflux Disease显示文摘 | Parakrama T. Chandrasoma Dilani M. Lokuhetty Tom R. Demeester Cedric G. Bremner Jeffrey H. Peters Stefan Oberg Susan Groshen | 2000 | The American Journal of Surgical Pathology2000，，3： | 1 |
| 8 | Prolonged breasffeeding reduces risk of breast cancer in Sri Lankan women: A case control study 显示文摘 | Malintha De Silva a Upul Senarath a Mangala Gunatilake b Dilani Lokuhetty | 2010 | Gancer Epidemiology2010，34，： | 1 |
| 9 | Biochar from sawmill residues:characterization and evaluation for its potential use in the horticultural growing media显示文摘Peat remains the primary constituent of horticultural growing media in professional use.However,use of peat in horticultural growing media results in greenhouse gas emissions and biodiversity loss due to excavation of natural peatlands.Biochar is gaining attention as a sustainable alternative to peat use in horticulture.This study examined the potential of biochar produced from a particular type of sawmill residue,as a partial replacement for peat in horticultural growing media.Five treatments including peat only,biochar only,biochar and peat in 1:1,1:3,and 3:1(V/V)ratios were assessed.The addition of biochar into growing media increased the pH and EC of the medium.However,physical properties(air-filled porosity and water holding capacity)were negatively affected with the increase in biochar content in the medium.According to the germination test results,biochar significantly improved germination and the shoot and root length of germinated seeds of cress,lettuce and tomato when compared to peat-only and biochar-only treatments.The inclusion of biochar in 25-50%volume ratio improved plant growth parameters compared to peat-only and biochar-only media.Results obtained from this study suggest that sawmill residue offers great potential as a feedstock for biochar production and inclusion of biochar has positive effects on seed germination and plant growth that might compete with modified peat. | Dilani Rathnayake Hamish Creber Reinhart Van Poucke Saran Sohi Erik Meers Ondřej Mašek Frederik Ronsse | 2021 | Biochar2021，3，2： | 0 |
| 10 | VicK激酶活性对变异链球菌的生物学影响显示文摘目的研究VicK蛋白的激酶活性对变异链球菌(S.mutans)生理及毒力因子的调控作用。方法使用PCR连接突变技术构建vicK基因敲出株,利用质粒搭载、表达VicK激酶活性废除蛋白。研究实验株菌落形态、隔夜培养菌液的变化、生物膜形成以及生物膜形成相关重要基因转录水平的改变。结果 VicKH217A的菌落表面较野生株UA159及互补株SMCVicK平滑,且菌落也较之高耸;VicKH217A隔夜培养的菌液中细胞共聚堆积在玻璃管底部;VicKH217A形成的生物膜未发生明显改变;gbpB、ftf、gtfD的表达受抑制而gtfB/C基因的表达上调(P<0.05)。结论 VicK的激酶活性对变异链球菌正常生长、生物膜形成及与编码生物膜形成相关蛋白基因的表达起着重要的调节作用。 | 张琼 王诗达 周学东 程磊 李雨庆 Dilani B.Senadheera Dennis G.Cvitkovitch | 2013 | 四川大学学报(医学版)2013，44，6： | 0 |
| 11 | Prevalence of Flatfoot and Its Correlation with Age,Gender and BMI among Undergraduates at the Faculty of Allied Health Sciences,General Sir John Kotelawela Defence University显示文摘Pes planus or flatfeet is a postural deformity which leads the entire sole of the foot to completely or near-completely touch the ground.Pes planus deformity occurs due to collapse of foot arches which can be congenital or pathological.The objective of this study was to determine the prevalence of flatfoot condition among undergraduates at the Faculty of Allied Health Sciences(FAHS),General Sir John Kotelawala Defence University(KDU)and its correlation with age,gender and BMI.A cross sectional study was conducted among 533 participants(Male=131,Female=402).Interviewer-administered questionnaire was used to collect the demographic data.BMI was calculated by obtaining height and weight measurements.Arch index method was used to determine the foot type taken using the Modified Harris Mat.The data analysis was done using SPSS software version 23.P value of less than 0.05 was considered as statistically significant.The study was done among people aged 19 to 26.The prevalence of flatfoot among this age group was 34.7%(n=185).Most of them are bilateral flat feet(73.5%),only 26.5%are unilateral flat feet.The proportion of patients with flat footedness was significantly higher in women(75%)than in men(25%).BMI in the overweight and obese categories(BMI>23)was statistically significant(p<0.05),which is 164(52.4%).Study shows a statistically significant association between flatfoot and increasing BMI beyond normal(p<0.05).There is no significant association between flatfoot with age and gender.Prevalence of flatfoot among allied health undergraduates was seemingly high requiring screening for early detection and appropriate referral for corrective measures. | Anjana Jayabandara Dileni Rodrigo Shaminda Nadeeshan Chathuri Wanniarachchi Prasad Rajathewa Thamasi Makuloluwa Dilani Perera | 2021 | Journal of Pharmacy and Pharmacology2021，9，9： | 0 |
| 12 | Comparison of blood glucose responses by cane sugar(Saccharum offi cinarum)versus coconut jaggery(Cocos nucifera)in type 2 diabetes patients显示文摘Type 2 diabetic mellitus is a predominant metabolic disorder that has a direct impact on human health.Although scientific data are deficit,coconut jaggery has been suggested as a better alternative for cane sugar by some individuals.This study was conducted to assess the credibility of this claim.Coconut jaggery was prepared at Coconut Research Institute,Sri Lanka and nutritional composition of coconut jaggery was compared with cane sugar using standard methods.Significantly higher(P<0.05)moisture(8.92±0.22)%,ash(2.09±0.33)%,protein(1.91±0.28)%,fat(0.14±0.02)%and fiber(0.05±0.03)%contents were observed in coconut jaggery compared to cane sugar.The total starch and total sugar content of the coconut jaggery was significantly(P<0.05)lower than that of the cane sugar.Forty-three patients(Male:16,Female:27)with type 2 diabetes from the Endocrinology unit,National Hospital Colombo,Sri Lanka were voluntarily engaged in the study,subjected to an initial health screening.Then,determination of postprandial blood glucose responses after intake of the standard(glucose),cane sugar and coconut jaggery.Average age of the selected group was(48.19±7.95)years and they were all overweight(BMI>23.0).The mean fasting blood glucose level and HbA1c of the subjects were(149.05±54.88)mg/dL and(9.170±2.022)%,respectively.There was no significant difference(P>0.05)in peak blood glucose concentrations or incremental area under the curve in blood glucose response of two test food.Therefore,coconut jaggery cannot be considered as a healthy substitute for cane sugar in type 2 diabetic patients. | Hewa Pathiranage Dilani Thilanka Hewa Pathirana Isuru Wijesekara Loku Liyana Waduge Chandi Yalegama Chaminda Garusinghe Madhura Arunoda Jayasinghe Kande Pramuditha Waidyarathne | 2022 | Journal of Future Foods2022，2，3： | 0 |
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