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| 1 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 3 | Effects of weak layers on particle velocity measurements显示文摘 | Fourney W L Dick R D Wang X J | 1997 | Rock Mechanics and Rock Engineering1997，30，1： | 1 |
| 4 | Impact of flue gas desulfurization-calcium sulfite and gypsum on soil microbial activity and wheat growth显示文摘 | LEE Y B BIGHAM J M DICK W A | 2008 | Soil Science2008，173，： | 1 |
| 5 | A simple reversed phase high-performance liquid chromatography method polysorbate 80 quantitation in monoclonal antibody drug products显示文摘 | ADAMO M DICK L W Jr QIU D F | 2010 | J Chromatogr B Analyt Technol Biomed Life Sci2010，878，21： | 1 |
| 6 | Preparing performance technologists:The role of the university显示文摘 | | 1995 | Performance Improvement1995，8，4： | 1 |
| 7 | An assessment of the root zone method of wastewater treatment显示文摘 | Conley L M Dick R I Lion L W | 1991 | Research Journal of the Water Pollution Control Federation1991，63，3： | 1 |
| 8 | A new device for internal fixation of thoraclumbar and Lumbar spine fractures: The''fixatear interne''显示文摘 | Dick W Kluger P Magerl F | 1985 | Paraplegia1985，23，： | 1 |
| 9 | A new device for internal fixation of thoracolumbar and Lumbar spine fractures:The 'fixateur interne”显示文摘 | Dick W Kliuqer P Magerl F | 1985 | Paraplegia1985，23，： | 1 |
| 10 | Plant strategies of manipulating predatorprey interactions through allelochemicals :Prospects for applaction in pest control 显示文摘 | DICKE M SABELIS M W TAKABAYASHI J | 1990 | Journal of chemical ecology1990，，： | 1 |
| 11 | Liming acid forest soils with flue gas desulfurization byproduct :growth of northern red oak and leach ate water quality显示文摘 | CREWS J T DICK W A | 1998 | Environ Pollut1998，103，1： | 1 |
| 12 | Mineralogic variability of the uppermost mantle along mid-ocean ridges显示文摘 | Dick H J B Fisher R L Bryan W B | 1984 | Earth and Planetary Science Letters1984，69，88： | 1 |
| 13 | Organic carbon,nitrogen,and phosphorus concentrations and p H in soil profiles as affected tillage intensity显示文摘 | Dick W A | 1983 | Soil Science Society1983，47，： | 1 |
| 14 | Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial 显示文摘 | Bischoff HA Sthelin HB Dick W | 2003 | J Bone Miner Res2003，18，2： | 1 |
| 15 | Tillage systems and soil properties in North America显示文摘 | Logan T J Lal R Dick W A | 1991 | Soil Tillage Research1991，20，： | 1 |
| 16 | Virtual prototyping of solid propellant rockets显示文摘 | HEATH M T DICK W A | | Computing in Science & Engineering0，2，2： | 1 |
| 17 | Sampling and quantifying invertebrates form drinking water distribution mains显示文摘 | Hein M van Lieverloo Dick W B Geo L B | 2004 | Water Research2004，38，3： | 1 |
| 18 | A new device for internal fixation of thoracolumbar and lumbar spine fractures:the'fixateur interne'显示文摘 | Dick W Kluger P Magerl F | 1985 | Paraplegia1985，23，4： | 1 |
| 19 | Accuracy of International Time and Frequency Comparisons Via Global Positioning System Satellites in Common-View显示文摘 | DAVIS Dick D Weiss M | 1985 | IEEE Transactions on Instrumentation and Measurement1985，34，2： | 1 |
| 20 | Preparing performance technologist:The role of the univershy显示文摘 | W | 1995 | Performance Improvemant Quarterly1995，8，4： | 1 |
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