|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Enhancement by parainfluenza 3 infection of contractile responses to substance P and capsaicin in airway smooth muscle from the guinea pig显示文摘 | Saban R Dick E C Fishleder R I | 1987 | Am Rev Respir Dis1987，136，3： | 2 |
| 4 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 5 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietie cell显示文摘 | Bonnet D Dick I E | 1997 | N atureM ed1997，3，7： | 1 |
| 6 | Transformer Diagnostic Testing by Frequency Response Analysis显示文摘 | DICK E P | 1978 | IEEEE Trans PAS1978，97，6： | 1 |
| 7 | The Multilevel Cycle of Anthropogenic Zinc显示文摘 | Graedel T E Beers Dick van Bertram M | 2005 | Journal of Industrial Ecology2005，9，3： | 1 |
| 8 | Ecology of infochemical use by natural enemies in a tritrophic context 显示文摘 | Vet L E M Dicke M | 1992 | Annual Review of Entomology1992，37，： | 1 |
| 9 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 10 | Contribution of Germline Muta- tions in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Can- cer in the Population显示文摘 | Song H Dicks E Ramus SJ | 2015 | J Clin Oncol2015，，： | 1 |
| 11 | Isolation of Lactococcus lactis nonsense suppressors and construction of a food-grade cloning vector显示文摘 | Dickely F Nilsson D Hansen E B | 1995 | Mol Microbiol1995，15，5： | 1 |
| 12 | Microbial biomassand enzyme and rehabilitated skid trailsoils显示文摘 | Dick R P Myrold D D Kerle E A | 1988 | SoilSoc Am J1988，52，： | 1 |
| 13 | The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems显示文摘 | Meyers JL Nyman E Loukola A Rose RJ Kaprio J Dick DM | | 0，，03： | 1 |
| 14 | Microbial biomass and soil enzyme activities in compacted and rehabilitated skid trail soils显示文摘 | Dick R P Myrold D D Kerle E A | 1988 | Soil Sci Soc Am J1988，52，2： | 1 |
| 15 | Transient Ground Potential Rise in Gas Insulated Subs- tations - Experimental Studies 显示文摘 | FUJIMOTO N DICK E P BOGGS S A FORD G L | 1982 | IEEE Trans on Power Apparatus and Systems1982，101，1： | 1 |
| 16 | Postoperative astigmatism and rotational stability after Artisan toric phakic intraocular lens implantation显示文摘 | Tehrani M Dick I-IB Schwenn O Blom E Schmidt AH | 2003 | J Cataract Refract Surg2003，29，9： | 1 |
| 17 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell 显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
| 18 | Formation of harzburgite by pervasive melt/rock reaction in the upper mantle 显示文摘 | Kelemen P B Dick H J Quick J E | 1992 | Nature1992，358，6388： | 1 |
| 19 | Evaluation of random amplified polymorphic DNA (RAPD)-PCR as a method to differentiate Lactobacillus acidophilus, Lactobacillus crispatus, Lactobacillus amylovorus, Lactobacillus gallinarum, Lactbacillus gasseri, and Lactobacillus johnsonii显示文摘 | DU PLESSIS E M DICKS L M | 1995 | Current Microbiology1995，31，： | 1 |
| 20 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell 显示文摘 | Bonnet D Dick J E | 1997 | Nat Med1997，3，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员