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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 3 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 4 | Bleeding Dieulafoy's-like lesions of the gut identified by capsule endoscopy显示文摘Dieulafoy's-like lesions (DLs-like) represent a cause of obscure gastrointestinal bleeding, enteroscopy being the main diagnostic and therapeutic procedure. Frequently, more than one enteroscopy is needed to identify the bleeding vessel. In our practice, video capsule endoscopy (VCE) identified and guided therapy in four cases of DLs-like; three of them were localized on the small bowel. We report, for the first time, a diagnosis of colonic DL-like performed by colon capsule endoscopy. Two patients presented with severe cardiovascular disorders, being hemodynamically unstable during VCE examination. Based on the VCE findings, only one invasive therapeutic procedure per patient was necessary to achieve hemostasis. VCE and enteroscopy may be regarded as complementary procedures in patients with gut DLs-like. | Lidia Ciobanu Oliviu Pascu Brindusa Diaconu Daniela Matei Cristina Pojoga Marcel Tantu | 2013 | World Journal of Gastroenterology2013，19，29： | 8 |
| 5 | Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters显示文摘BACKGROUND Obesity and diabetes are associated with high levels of oxidative stress.In Romanian patients with obesity and(or)diabetes,this association has not been sufficiently explored.AIM To evaluate oxidative stress in obese and(or)diabetic subjects and to investigate the possible correlations between oxidative stress and anthropometric/biochemical parameters.METHODS Oxidative stress was evaluated from a single drop of capillary blood.Reactive oxygen species(ROS)were evaluated using the free oxygen radical test(FORT).The free oxygen radical defence(FORD)assay was used to measure antioxidant levels.RESULTS FORT levels were higher in obese subjects(3.04±0.36 mmol/L H2O2)vs controls(2.03±0.14 mmol/L H2O2)(P<0.0001).FORD levels were lower in obese subjects(1.27±0.13 mmol/L Trolox)vs controls(1.87±1.20 mmol/L Trolox)(P=0.0072).Obese diabetic subjects had higher FORT values(3.16±0.39 mmol/L H2O2)vs non-diabetic counterparts(2.99±0.33 mmol/L H2O2)(P=0.0233).In obese subjects,FORT values correlated positively with body mass index(BMI)(r=0.48,P=0.0000),waist circumference(WC)(r=0.31,P=0.0018),fasting plasma glucose(FPG)(r=0.31,P=0.0017),total cholesterol(TC)(r=0.27,P=0.0068)and uric acid(r=0.36,P=0.0001).FORD values correlated negatively with BMI(r=-0.43,P=0.00001),WC(r=-0.28,P=0.0049),FPG(r=-0.25,P=0.0130),TC(r=-0.23,P=0.0198)and uric acid(r=-0.35,P=0.0002).In obese diabetic subjects,FORT values correlated positively with BMI(r=0.49,P=0.0034)and TC(r=0.54,P=0.0217).FORD values were negatively associated with BMI(r=-0.54,P=0.0217)and TC(r=-0.58,P=0.0121).CONCLUSION Oxidative stress levels,as measured by the FORT and FORD assays,were higher in obese subjects vs controls.ROS levels were elevated in diabetic obese patients vs obese non-diabetic patients and controls. | Mihnea-Alexandru Găman Mirela Elena Epîngeac Camelia Cristina Diaconu Amelia Maria Găman | 2020 | World Journal of Diabetes2020，11，5： | 3 |
| 6 | Murine models based on acute myeloid leukemia-initiating stem cells xenografting显示文摘Acute myeloid leukemia(AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells(LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells. Animal models provides the means to investigate the factors responsible for leukemic transformation, the intrinsic differences between secondary post-myeloproliferative neoplasm AML and de novo AML, especially the signaling pathways involved in inflammation and hematopoiesis. However, AML proved to be one of the hematological malignancies that is difficult to engraft even in the most immunodeficient mice strains, and numerous ongoing attempts are focused to develop 'humanized mice' that can support the engraftment of LSC. This present review is aiming to in-troduce the field of AML pathogenesis and the concept of LSC, to present the current knowledge on leukemic blasts surface markers and recent attempts to develop best AML animal models. | Cristina Mambet Mihaela Chivu-Economescu Lilia Matei Laura Georgiana Necula Denisa Laura Dragu Coralia Bleotu Carmen Cristina Diaconu | 2018 | World Journal of Stem Cells2018，10，6： | 2 |
| 7 | Testosterone,cardiomyopathies,and heart failure:a narrative review显示文摘Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure. | Rodica Diaconu Ionuţ Donoiu Oana Mirea Tudor Adrian Bălşeanu | 2021 | Asian Journal of Andrology2021，23，4： | 2 |
| 8 | Activation of toll-like receptor (TLR) 2, TLRA, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation 显示文摘 | Johnson AC Heinzel FP Diaconu E Sun Y Hise AG Golenbock D | 2005 | Invest Ophthalmol Vis Sci2005，46，2： | 1 |
| 9 | CXC chemokine receptor 2 but not C C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness) 显示文摘 | Hall LR Diaconu E Patel R | 2001 | J Immunol2001，166，： | 1 |
| 10 | Apoptosis is inducedin both drug-s ensitive and multidmg-resistant hepatoma cells bysomatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | BrJ Cancer1999，80，8： | 1 |
| 11 | Analysis of a solarassisted ejector cooling system for air conditioning显示文摘 | Varga S C Oliveira A Diaconu B | 2009 | International Journal of Low-Carbon Technologies2009，4，1： | 1 |
| 12 | Novel concept ofcomposite phase change material wall system foryear-round thermal energy savings显示文摘 | DIACONU B M CRUCERU M | 2010 | Energy andBuildings2010，42，10： | 1 |
| 13 | Plasticity of regulatory T cells under cytokine pressure显示文摘 | Diaconu CC Neagu AI Lungu R | 2010 | Roum Arch Microbiol Immu- nol2010，69，4： | 1 |
| 14 | Apoptosis is induced in both drug - sensitive and multidrug - resistant hepatoma cells by somatostatin analogue TT- 232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 15 | Armed oncolytic virus enhances immune functions of chimeric antigen receptor-modified T cells in solid tumors显示文摘 | Nishio N Diaconu I Liu H | 2014 | Cancer Research2014，74，18： | 1 |
| 16 | The applicability of VITROVAC 6025 X ribbons for parallel-gated configuration sensors显示文摘 | Moldovanu A Diaconu E D Moldovanu E | 2000 | Sensors and Actuators2000，81，： | 1 |
| 17 | Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus 显示文摘 | Cerullo V Diaconu I Kangasniemi L | 2011 | Mol Ther2011，19，9： | 1 |
| 18 | Escape from competi- tion: neighbors reduce Centaurea stoebe performance at home but not away显示文摘 | Callaway RM Waller LP Diaconu A | 2011 | Ecology2011，92，： | 1 |
| 19 | Primary malignant fibrous histiocytoma of the right ventricle: case report and review of the literature显示文摘 | Balaceanu A Mateescu D Diaconu C | 2010 | J Ultrasound Med2010，29，4： | 1 |
| 20 | Apoptosis is induced in both drug-semitive and multidrug-resist ant hepatoma cells by somatostatin analogue TT-232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
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