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| 1 | Novel 18-glycyrrhet- inic acid analogues as potent and selective inhibitors of 11 -hydroxys- teroid dehydrogenases显示文摘 | Xiangdong S Harshani L Dharshini G | 2004 | Bioorganic & Medicinal Chemistry2004，12，17： | 1 |
| 2 | Additive manufacturing of biodegradable porous orthopaedic screw显示文摘Advent of additive manufacturing in biomedical field has nurtured fabrication of complex,customizable and reproducible orthopaedic implants.Layer-by-layer deposition of biodegradable polymer employed in development of porous orthopaedic screws promises gradual dissolution and complete metabolic resorption thereby overcoming the limitations of conventional metallic screws.In the present study,screws with different pore sizes(916×918μm to 254×146μm)were 3D printed at 200μm layer height by varying printing parameters such as print speed,fill density and travel speed to augment the bone ingrowth.Micro-CT analysis and scanning electron micrographs of screws with 45%fill density confirmed porous interconnections(40.1%)and optimal pore size(259×207×200μm)without compromising the mechanical strength(24.58±1.36 MPa).Due to the open pore structure,the 3D printed screws showed increased weight gain due to the deposition of calcium when incubated in simulated body fluid.Osteoblast-like cells attached on screw and infiltrated into the pores over 14 days of in vitro culture.Further,the screws also supported greater human mesenchymal stem cell adhesion,proliferation and mineralized matrix synthesis over a period of 21 days in vitro culture as compared to non-porous screws.These porous screws showed significantly increased vascularization in a rat subcutaneous implantation as compared to control screws.Porous screws produced by additive manufacturing may promote better osteointegration due to enhanced mineralization and vascularization. | Ramya Dhandapani Priya Dharshini Krishnan Allen Zennifer Vishal Kannan Amrutha Manigandan Michael R.Arul Devina Jaiswal Anuradha Subramanian Sangamesh Gurappa Kumbar Swaminathan Sethuraman | 2020 | Bioactive Materials2020，5，3： | 1 |
| 3 | Increased vascular endothelial growth factor and receptors:relationship to angiogenesis in asthma显示文摘 | Bryce N F Dharshini W Ling Z | | 0，，11： | 1 |
| 4 | HIV-1infection of human macrophages directly induces Viperin which inhibits viral production显示文摘 | Najla Nasr Susan Maddocks Stuart G Turville Andrew N Harman Natalie Woolger Karla J Helbig John Wilkinson Chris R Bye Thomas K Wright Dharshini Rambukwelle Heather Donaghy Michael R Beard Anthony L Cunningham | 2012 | Blood2012，120，4： | 1 |
| 5 | Efficacy and Tolerability of 0.1%Adapalene With 1%Clindamycin Versus 0.1%Adapalene With 2.5%Benzoyl Peroxide on Acne Vulgaris:A Case Control Study显示文摘Objective:Combination therapy is currently the preferred acne treatment.We conducted this study to compare the efficacy and tolerability of 0.1%adapalene with 1%clindamycin versus 0.1%adapalene with 2.5%benzoyl peroxide(BPO)in the treatment of acne vulgaris.Methods:This study was conducted over a period of 1 year from September 2014 to September 2015.One-hundred patients aged 14 to 30 years with mild to moderate acne vulgaris were included.The patients were randomly allocated to 2 equal groups(n=50 in each group),and received a topical combination of 0.1%adapalene with 1%clindamycin andtopical combination of 0.1%adapalene with 2.5%BPO,respectively).The efficacy and tolerability of two treatments were compared.The unpaired studentt test was used to compare the difference in continuous variables between 2 groups,while the chi-square test or Fisher exact test was used for categorical variables.Results:One-hundred patients with mild to moderate acne vulgaris were randomly allocated to 2 equal groups(n=50 in each group).After 12 weeks of treatment,there were no significant differences between the adapalene-clindamycin and adapalene-BPO in the mean reductions in the numbers of non-inflammatory lesions(11.16±8.01 and 11.12±8.62,respectively),inflammatory papules(49.78±37.57 and 50.48±36.57,respectively),and total lesions(67.50±44.59 and 70.12±46.83,respectively).The incidence of a burning sensation was significantly greater in the adapalene-BPO group than the adapalene-clindamycin group(32%vs.6%;P=0.002).Conclusion:Topical adapalene plus clindamycin and adapalene plus BPO had similar efficacies in the treatment of acne.Adapalene with clindamycin was better tolerated than adapalene with BPO. | Annie Priya Dharshini Inbamani Navakumar Manickam Kannan Gopalan | 2023 | International Journal of Dermatology and Venereology2023，6，1： | 0 |
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