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| 1 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 2 | The human brain hexacoordinated neuroglobin three-dimensional structure 显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，1： | 1 |
| 3 | Use of clopidogrel with or without aspirin in patients taking oral an- ticoagulant therapy and undergoing percutaneous coronary in- tervention: an open label, randomized, controlled trial 显示文摘 | Dewilde W J M Oirbans T Verheugt F W A | 2013 | Lancet2013，381，9872： | 1 |
| 4 | Crystal structure of cytoglobin:the fourth globin type discovered in man displays heme hexa-coordination显示文摘 | de SD Dewilde S Pesce A | 2004 | J Mol Biol2004，336，4： | 1 |
| 5 | The human brainhexacoordinated neuroglobin three-dimensional structure显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，12： | 1 |
| 6 | Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin: Molecular mechanisms and physiological significance 显示文摘 | Fago A Hundahl C Dewilde S | 2004 | J Biol Chem2004，279，44： | 1 |
| 7 | Unusual stability of hu-man neuroglobin at low pH-molecular mechanisms and bi-ological significance显示文摘 | Picotti P Dewilde S Fago A | 2009 | FEBS J2009，276，： | 1 |
| 8 | Longitudinal study on the influence of Nd: YAG laser irradiation on microleakage associated with two filling techniques显示文摘 | Meire M Mavridou A Dewilde N | 2009 | Photomed Laser Surg2009，27，4： | 1 |
| 9 | Methylphenidate delivery mechanisms for the treatment of children with attention deficit hyperactivity disorder: Heterogeneity in parent preferences显示文摘 | Lloyd A Hodgkins P Dewilde S | 2011 | Int J Technol Assess HeahhCare2011，27，21： | 1 |
| 10 | Haematological aspect of the thermo acclamatory process in the Rainbow trout,Salmogairdneri显示文摘 | Dewilde M A Houson A H | 1967 | J Fish Res Bd Can1967，27，： | 1 |
| 11 | Haematological aspect of the themno acclimatory processs in the rainbow trout,Salmo gairdner显示文摘 | Dewilde M A Houson A H | 1967 | J Fish Res Bd Can1967，27，： | 1 |
| 12 | Multicenter study of the in vitro sensitivity of genital mycoplasma to antibiotics显示文摘 | Bebear C de Barbeyrac B Dewilde A | 1993 | Patol Biol Paris1993，41，： | 1 |
| 13 | Methylphenidate delivery mechanisms for the treatment of children with attention deficit hyperactivity disorder:Heterogeneity in parent preferences 显示文摘 | Lloyd A Hodgkins P Dewilde S | 2011 | Int J Technol Assess Health Care2011，27，3： | 1 |
| 14 | Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity 显示文摘 | Pesce A Dewilde S Nardini M | 2003 | structur2003，11，9： | 1 |
| 15 | The human brain hexacoordinated neuroglobin three-dimensional structure显示文摘 | Pesce A Dewild S Burmester T | 2004 | Micron2004，35，1： | 1 |
| 16 | Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo显示文摘 | Vorotnikova E Mclntosh D Dewilde A | 2010 | Matrix Biology2010，29，8： | 1 |
| 17 | Reactions of ferrous neu- roglobin and cytoglobin with nitrite under anaerobic condi- tions显示文摘 | Petersen MG Dewilde S Fago A | 2008 | Journal of inorganic biochemistry2008，102，9： | 1 |
| 18 | Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity显示文摘 | Pesce A Dewilde S Nardini M | 2003 | Structure2003，1，9： | 1 |
| 19 | Unusnal siability of human neurog- lob in at low PH- molecular mechanisms and biological significance 显示文摘 | Picctti P Dewilde S Fago A | 2009 | Febs Journal2009，276，23： | 1 |
| 20 | Use of elopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention : an open-label, randomised, controlled trial 显示文摘 | Dewilde W J M Oirbans T Verheugt F W A etal | 2013 | Lancet2013，381，9872： | 1 |
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