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| 1 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 2 | Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model显示文摘Multicellular layers(MCLs) have previously been used to determine the pharmacokinetics of a variety of different cancer drugs including paclitaxel, doxorubicin, methotrexate, and 5-fluorouracil across a number of cell lines. It is not known how nanoparticles(NPs) navigate through the tumor microenvironment once they leave the tumor blood vessel.In this study, we used the MCL model to study the uptake and penetration dynamics of NPs. Gold nanoparticles(GNPs)were used as a model system to map the NP distribution within tissue-like structures. Our results show that NP uptake and transport are dependent on the tumor cell type. MDA-MB-231 tissue showed deeper penetration of GNPs as compared to MCF-7 one. Intracellular and extracellular distributions of NPs were mapped using Cyto Viva imaging. The ability of MCLs to mimic tumor tissue characteristics makes them a useful tool in assessing the efficacy of particle distribution in solid tumors. | Darren Yohan Charmainne Cruje Xiaofeng Lu Devika Chithrani | 2015 | Nano-Micro Letters2015，7，2： | 3 |
| 3 | Size-Dependent Gold Nanoparticle Interaction at Nano–Micro Interface Using Both Monolayer and Multilayer(Tissue-Like) Cell Models显示文摘Gold nanoparticles(GNPs) are emerging as a novel tool to improve existing cancer therapeutics. GNPs are being used as radiation dose enhancers in radiation therapy as well as anticancer drugs carriers in chemotherapy. However,the success of GNP-based therapeutics depends on their ability to penetrate tumor tissue. GNPs of 20 and 50 nm diameters were used to elucidate the effects of size on the GNP interaction with tumor cells at monolayer and multilayer level. At monolayer cell level, smaller NPs had a lower uptake compared to larger NPs at monolayer cell level. However, the order was reversed at tissue-like multilayer level. The smaller NPs penetrated better compared to larger NPs in tissue-like materials.Based on our study using tissue-like materials, we can predict that the smaller NPs are better for future therapeutics due to their greater penetration in tumor tissue once leaving the leaky blood vessels. In this study, tissue-like multilayer cellular structures(MLCs) were grown to model the post-vascular tumor environment. The MLCs exhibited a much more extensive extracellular matrix than monolayer cell cultures. The MLC model can be used to optimize the nano–micro interface at tissue level before moving into animal models. This would accelerate the use of NPs in future cancer therapeutics. | Darren Yohan Charmainne Cruje Xiaofeng Lu Devika B.Chithrani | 2016 | Nano-Micro Letters2016，8，1： | 2 |
| 4 | A Multistrategy Learning Scheme for Agent Knowledge Acquistion 显示文摘 | Diana G Devika S | 1994 | Informatica1994，17，： | 1 |
| 5 | A Genetic Algorithm Approach for Solving a Closed Loop Supply Chain Model: A Case of Battery Recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 6 | Analysis of third party reverse logistics provider using interpretive structural modeling显示文摘 | Kannan Govindan Murugesan Palaniappan Qinghua Zhu Devika Kannan | 2012 | International Journal of Production Economics2012，，1： | 1 |
| 7 | A genetic algorithm approach for solving a closed loop supply chain model: A case of battery recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Model- ling2010，34，3： | 1 |
| 8 | An optimization model for product returns using genetic algorithms and artificial immune system显示文摘 | Ali Diabat Devika Kannan Mathiyazhagan Kaliyan Davor Svetinovic | 2013 | Resources Conservation & Recycling2013，，： | 1 |
| 9 | Evaluating the drivers of corporate social responsibility in the mining industry with multi criteria approach= A multi-stakeholder perspective显示文摘 | Govindan K Devika K Shankar K M | 2014 | JournaI of Cleaner Production2014，84，： | 1 |
| 10 | A genetic algorithm approach for solving a closed loop supply chain model: A case of battery recycling显示文摘 | KANNAN G SASIKUMAR P DEVIKA K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 11 | A carbon footprint based reverse logistics network design model 显示文摘 | Devika Kannana Ali Diabatb Mahmoud Alrefaeic | 2012 | Resources Conservation and Recycling2012，67，1： | 1 |
| 12 | Designing a sustainable closed-loop supply chain network based on triple bottom line approach: A comparison of metaheuristics hybridization techniques显示文摘 | DEVIKA K JAFARIAN A NOURBAKHSH V | 2014 | European Journal of Operational Research2014，235，3： | 1 |
| 13 | CSFproteinsasdis-creminatorymarkersoftubercularandpyogenicmeningi-tis显示文摘 | ShekharR RaoJR DeviKA etal | 2013 | JClinDiagnRes2013，7，8： | 1 |
| 14 | Protective effect of (-)-epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: a histopathological study显示文摘 | Devika PT Stanely Maingen Prince P | 2008 | Biomed Pharmacother2008，62，10： | 1 |
| 15 | Microstructure dependent physical properties of evaporated tin sulfide films 显示文摘 | DEVIKA M RAMAKRISHNA K T | 2006 | Journal of Applied Physics2006，100，02： | 1 |
| 16 | Reverse logistics and closed-loop supply chain: A compre- hensive review to explore the future显示文摘 | KANNAN Govindan HAMED Soleimani DEVIKA Kannan | 2015 | European Journal of Operational Research2015，，240： | 1 |
| 17 | Selecting green suppliers based on GSCM practices: Using fuzzy ToPsIs applied to a Brazilian electronics company显示文摘 | Devika Kannan Ana Beatriz Lopes de Sousa Jabbour Charbel Jose Chiappetta Jabbour | 2014 | European Journal of Operational Research2014，233，2： | 1 |
| 18 | A genetic algorithm approach for solving a closed loop supply chain model: a case of battery recycling显示文摘 | Kannan G Sasikumar P Devika K | 2010 | Applied Mathematical Modelling2010，34，3： | 1 |
| 19 | Reverse logistics and closed-loop supply chain: A comprehensive review to ex- plore the future显示文摘 | KANNAN G HAMED S DEVIKA K | 2015 | European Journal ot Operational Re search2015，240，3： | 1 |
| 20 | Close-spaced Evaporated ZnSe Films:Preparation and Characterization显示文摘 | Venkata Subbaiah Y P Prathap P Devika M | 2005 | Physica B2005，365，： | 1 |
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