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| 1 | Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer显示文摘AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).CONCLUSION: The Present data suggest that eN OS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC. | Devulapalli Krishnaveni Bhayal Amar Chand Porika Shravan Kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy Nallari Pratibha N Balakrishna Ananthapur Venkateshwari | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 2 |
| 2 | In vitro effects of natural plant polyphenols on the proliferation of normal and abnormal human lymphocytes and their secretions of interleukin-2显示文摘 | Devi M A Das N P | 1993 | Cancer Lett1993，69，3： | 1 |
| 3 | Seasonal Dynamics in Soil Microbial Biomass C, N and P in a Mixed-Oak Forest Ecosystemof Manipur, North East India显示文摘 | DEVI N B YADAVA P S | 2006 | Appl Soil Ecol2006，31，： | 1 |
| 4 | Seasonal dynamics in soil microbial biomass C, N and P in a mixed-oakforest ecosystem of Manipur, North- east India显示文摘 | Bijayalaxmi Devi N Yadava P S | 2006 | Appolied Soil Ecology2006，31，3： | 1 |
| 5 | Separation of divalent manganese and cobalt ions from sulphate solutions using sodium salts of D2EHPA,PC 88A and Cyanex 272显示文摘 | Devi N B Nathsarma K C Chakravortty V | | 0，，2： | 1 |
| 6 | An incremental prototype set building technique显示文摘 | Devi F S Murty M N | 2002 | Pattern Recognition2002，35，2： | 1 |
| 7 | Multilocus se quence typing method for identification and genotypic classification of pathogenic Leptospira species 显示文摘 | Ahmed N Devi SM Valverde Mde L | 2006 | Annals of Clinical Microbiology and Antimicrobials2006，5，： | 1 |
| 8 | Effects of ferulic acid on growth and hydrolytic enzyme activities of germinating maize seeds显示文摘 | Devi R S Prasad M N V | 1992 | Journal of Chemical Ecology1992，18，： | 1 |
| 9 | Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum显示文摘 | GANASOUNDARI A UMA DEVI P RAO M N A | 1997 | Mutation Research1997，373，： | 1 |
| 10 | Calcium homeostasis in human melanocytes:role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light显示文摘 | DEVI S KEDLAYA R MADDODI N | 2009 | 297(3):C679-6872009，297，3： | 1 |
| 11 | Seasonal dynamics in soil microbial biomass C, N and P in a mixed-oak forest ecosystem of Manipur, Northeast India显示文摘 | Devi N B Yadava P S | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 12 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 13 | Long-term effects of diagnostic ultrasound during fetal period on postnatal development and adult behavior of mouse显示文摘 | Suresh R Uma Devi P Ovchinnikov N | 2002 | Life Sci2002，71，3： | 1 |
| 14 | Bioethanol production from rice straw: An overview显示文摘 | Binod P Sindhu R Singhania RR Vikram S Devi L Nagalakshmi S Kurien N Sukumaran RK Pandey A | 2010 | Bioresource Technology2010，101，13： | 1 |
| 15 | Resolution of Racemic2-Chlorophenyl Glycine with Immobilized Penicillin G Acylase显示文摘 | Fadnavis N W Devi A V Jasti L S | 2008 | Tetrahedron:Asymetry2008，19，20： | 1 |
| 16 | The FMR-1 protein is cytoplas-mic, most abundant in neurons and appears normal in carriers of afragile X premutation显示文摘 | Devys D Lutz Y Rouyer N | 1993 | Nat Genet1993，4，4： | 1 |
| 17 | Phytoplankton and zooplankton of some paddy-cum-prawn culture fields in and around Cochin显示文摘 | Gopalakrishnan T C Lalithambika Devi C B Aravindaksha P N | 1988 | Mahasagar Dona Paula1988，21，2： | 1 |
| 18 | Seasonal dynamics in soil microbial biomass C,N and P in a mixed-oak forest ecosystem of Manipur,North-east India显示文摘 | Devi N B Yadava P S | 2006 | Applied Soil Ecology2006，31，3： | 1 |
| 19 | Distress, anxiety, and depression in cancer patients undergoing chemothe- rapy显示文摘 | Pandey M Sarita G P Devi N | 2006 | World J Surg Oncol2006，4，： | 1 |
| 20 | A new synthesis of deoxybenzoins显示文摘 | Devi N Jain N Krishnamurty H G | 1993 | Indian J Chem1993，32，3： | 1 |
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