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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Studies in 3,4 diaryl-1,2,5-oxadiazoles and their N oxides: Search for better COX-2 inhibitors显示文摘 | Mange R Y Shrikant T S Devendra S P | 2007 | Acta Pharm2007，57，： | 1 |
| 3 | Revision total hip replacement:predictors of blood loss,transfusionrequirements, and length of hospitalisation 显示文摘 | Devendra Mahadevan Christopher Challand Jonathan Keenan t | 2010 | J Orthop Traumatol2010，11，3： | 1 |
| 4 | Hydrogenolysis of Glycerol to 1, 2-Propanediol over Nano-fibrous Ag-OMS-2 Catalysts显示文摘 | Ganapati D Y Payal A C Devendra P T | 2012 | Ind Eng Chem Res2012，51，： | 1 |
| 5 | Application of ozone based treatmentsof secondary effluents显示文摘 | Smriti T Vinita P Devendra M T | 2011 | Bioresource Technology2011，102，： | 1 |
| 6 | Application of ozone based treatments of secondary effluents 显示文摘 | Smriti T Vinita P Devendra M T | 2011 | Bioresource Technology2011，102，： | 1 |
| 7 | The use of phage display to distinguish insulin autoantibody (IAA) from insulin antibody(IA) idiotypes显示文摘 | Devendra D Galloway T S Horton S J | 2003 | Diabetologia2003，46，6： | 1 |
| 8 | The use of phage display to distinguish insulin autoantibody (IAA) from insulin antibody (IA) idiotypes 显示文摘 | DEVENDRA D GALLOWAY T S HORTON S J | 2003 | Diabetologia2003，46，6： | 1 |
| 9 | Earth-Abundant Non-toxic Cu2Zn Sn S4Thin Films by Direct Liquid Coating From Metal-Thiourea Precursor Solution显示文摘 | Tapas K C Devendra T | 2012 | Solar Energy Materials and Solar Cells2012，101，： | 1 |
| 10 | Microwave enhanced synthesis of chitosan -graft-polyacrylamide显示文摘 | VANDANA S ASHUTOSH T DEVENDRA N T | 2006 | Polymer2006，47，7： | 1 |
| 11 | Studies in 3,4-diaryl-1,2,5-oxadiazoles and their N-oxides: Search for better COX-2 inhibitors显示文摘 | Mange R Y Shrikant T S Devendra S P | | Acta Pharm0，57，： | 1 |
| 12 | Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetes显示文摘 | Aly T Devendra D Barker J | 2004 | Diabetes Care2004，27，5： | 1 |
| 13 | New focus of Kyasanur Forest disease virus activity in a tribal area in Kerala, India, 2014显示文摘Background:Kyasanur Forest disease(KFD)is a febrile illness characterized by hemorrhages,and is reported endemic in the Shimoga district in Karnataka state,India.It is caused by the KFD virus(KFDV)of the family Flaviviridae,and is transmitted to monkeys and humans by Haemaphysalis ticks.Findings:We investigated a new focus of KFD among tribals in a reserve forest in Kerala state,India.A suspected case was defined as a person presenting with acute fever,headache,or myalgia.Human sera were collected and tested for KFDV RNA by real-time RT-PCR,RT-nPCR assay,and anti-KFDV IgM and IgG by ELISA.The index case was a tribal woman with febrile illness,severe myalgia,gum bleeding,and hematemesis.Anti-KFDV IgM antibody was detected in acute and convalescent sera of the index case along with IgG in the second serum.None of her family members reported fever.On verbal autopsy,two more fatal cases were identified as probable primary cases.Acute serum from a case in the second cluster was detected positive for KFDV RNA by real time RT-PCR(Ct=32)and RT-nPCR.Sequences of E gene showed highest similarity of 98.0%with the KFDV W-377 isolate nucleotide and 100%identity with amino acid.Anti-KFDV IgM was detected in the serum of one family member of the index case,as well as in one out of 17 other tribals.Conclusions:We confirmed a new focus of KFDV activity among tribals in a reserve forest in the Malappuram district of Kerala,India. | Babasaheb V Tale Anukumar Balakrishnan Pragya D Yadav Noona Marja Devendra T Mourya | 2015 | Infectious Diseases of Poverty2015，4，1： | 0 |
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