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25篇 您的检索式:作者名="Detlef P"
    题名 作者 年代 出处 被引量
1Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer显示文摘瞄准:在肝细胞癌(HCC ) 检验导致 erlotinib 的生长抑制的内在的机制。方法:在基因表示的导致 Erlotinib 的改变用 cDNA 数组技术被评估;在蛋白质表示或蛋白质激活的变化用西方的弄污由于象 IGF-1-induced EGFR transactivation 一样的 erlotinib 治疗被调查。结果:Erlotinib 治疗禁止了 mitogen 激活和抄写(STAT ) 的激活的蛋白质(地图)-kinase 小径和信号变换器调停了表明哪个导致了调整由 cDNA 数组技术示威了的基因的 apoptosis 和房间周期的一个改变的表达式。象与象 Bcl-2, Bcl-X (L) 或 jun D 一样的 antiapoptotic 因素的一条下面规定联系的 caspases 和 gadds 一样的 proapoptotic 因素的 Overexpression 说明了让 erlotinib 的力量导致 apoptosis。支持 G1/S-transition 的房间周期管理者并且在 cyclin 依赖的激酶禁止者和 gadds 的表示上的 Downregulation 响应 erlotinib 贡献了 G1/G0-arrest 的正式就职。而且,我们显示了由 IGF-1-receptor 的调停 EGFR 的发信号的 transactivation 并且在受体受体十字谈话显示出 erlotinib 的禁止的效果。结论:我们的学习在 HCC 房间和 thus 使 EGFR-TK-inhibition 的行动的机制的理解清楚些可能便于 additively 或 synergistically 行动的联合治疗的设计。而且,我们对 erlotinib 处理作出回应的小径上的数据能在以后预言肿瘤的应答的海角到 EGFR-TKIs 是有用的。Alexander Huether Michael Hpfner Andreas P Sutter Viola Baradari Detlef Schuppan Hans Scherübl 2006World Journal of Gastroenterology2006,12,32:7
2Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae 2008Journal of Clinical Investigation2008,,10:3
3Cobalt( Ⅱ ) tetrasulfophthalocyanine on titanium dioxide: a new efficient electron relay for the photocatalytic formation and depletion of hydrogen peroxide in aqueous suspensions显示文摘Andrew P Hong Detlef W Bahnemann Michael R Hoffmann 1987J Phys Chem1987,91,8:1
4Monitoring gene flow from transgenic sugar beet using cytoplasmic male-sterile bait plants显示文摘CHRIST1ANE S Matthias P Detlef B 2009Molecular Ecology2009,9,12:1
5Climate policy through changing consumption choices:Options and obstacles for reducing greenhouse gas emissions显示文摘Girod B Detlef P V Edgar G H 2014Global Environmental Change2014,25,4:1
6Exploring past and future changes in the ecological footprint for world regions 显示文摘Detlef P Van Vuuren Bouwman L F 2005Ecological Economics2005,52,1:1
7Advanced Liquid crystal for televison显示文摘Detlef P Kazuaki T 2004J Mater Chem2004,14,:1
8Optimization of liquid crystal for television显示文摘Detlef P Kazuaki T 2005Journal of the Society for Information Display2005,13,8:1
9Exploring pest and future changes in the ecological footprint for world resious显示文摘 van Vuuren Lex F Bouwman 2005Ecological Economics2005,52,:1
10Advanced Liquid Crystals for Television显示文摘Detlef P Kazuaki T 2004J Mater Chem2004,14,8:1
11Ex vivo isolation and characterization of CD4^+ CD25^+ T cells with regulatory properties from human blood 显示文摘Detlef D Heidi P Susanne B 2001J Exp Med2001,193,:1
12A new technical approach to quantify cell-cell adhesion forces by AFM显示文摘PIERRE H P KATE P DETLEF K 2006Uhramicroscopy2006,106,89:1
13Hepatic fibrosis:From bench to bedside显示文摘Detlef S Yury P 2002J Gastroenterol Hepatol2002,17,3:1
14Advanced liquid crystals for television显示文摘Detlef P Kazuaki T 2004J Mater Chem2004,14,:1
15Optimization of liquid crystals for television显示文摘Detlef P Kazuaki T 2005Journal of the SID2005,13,8:1
16Analysing the costs and benefits of climate policy: Value judgements and scientific uncertainties 显示文摘Andries F Hof Michel G J den Elzen Detlef P van Vuuren 2008Global Environmental Change2008,18,3:1
17Microstructure fabrication with a CO2 laser system 显示文摘Detlef S Henning K Kutter J P 2004J Micromech Microeng2004,14,:1
18Compari- son of top-down and bottom-up estimates of sectoral and regional greenhouse gas emission reduction poten- tials显示文摘DETLEF P V MONIQUE H TERRY B 2009Energy Policy2009,37,12:1
19Ex vivo isolation and characterization of CD4+CD25+T cells with regulatory properties from human blood显示文摘Detlef D Hedi P Susanne B 2001J Exp Med2001,193,11:1
20Modeling global residential sector energy demand for heating and air conditioning in the context of climate change 显示文摘Isaac Morna van Vuuren Detlef P 2009Energy Policy2009,37,2:1
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