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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | An fMRI Study of Personality Influences on Brain Reactivity to Emotional Stimuli显示文摘 | Canli T Zhao Z Desmond E J Kang E Gross J Gabrieli J D E | | 0，，01： | 1 |
| 3 | Reducing salt: a challenge for the meat industry显示文摘 | DESMOND E | 2006 | Meat Science2006，74，1： | 1 |
| 4 | Antagonistic interaction between abacisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis显示文摘 | ANDERSON J P BADRUZSAUFARI E SCHENK P M MANNERS J M DESMOND O J EHLERT C | 2004 | Plant Cell2004，16，： | 1 |
| 5 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 6 | Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection显示文摘 | Small PM Shafer RW Hopewell PC Singh SP Murphy MJ Desmond E Sierra MF Schoolnik GK | 1993 | N Engl J Med1993，328，16： | 1 |
| 7 | First documentation of isoniazid reversion in Mycobacterium tuberculosis显示文摘 | Richardson E T Lin S Y Pinsky B A Desmond E Banaei N | 2009 | Int J Tuberc Lung Dis2009，13，： | 1 |
| 8 | Fatigue inBreast Cancer Survivors: Occurrence Correlates, and Im-pact on Quality of Life显示文摘 | Bower J E Ganz P A Desmond K A | 2000 | Clin 0neol2000，18，4： | 1 |
| 9 | Effect of rapid and conventional cooling methods on the quality of cooked ham joints显示文摘 | Desmond E M Kenny T A Ward P | 2000 | Meat Science2000，56，3： | 1 |
| 10 | Improved survival of Lactobacillus paracasei NFBC338in spray dried powders containing gum acacia显示文摘 | Desmond C Ross R P O’Callaghan E | 2002 | Journal of Applied Microbiology2002，93，： | 1 |
| 11 | Improved survival of Lactobacillus paracasei NFBC 338 in spray- dried powders containing gum acacia显示文摘 | Desmond C Ross R P O' Callaghan E | 2002 | Journal of Applied Microbiology2002，93，： | 1 |
| 12 | Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study显示文摘 | Desmond JE Chen SH DeRosa E | 2003 | Neuroimage2003，19，4： | 1 |
| 13 | Effect of rapid and conventional cooling methods on the quality of cooked ham joints 显示文摘 | DESMOND E M KENNY T A WARD P | 2000 | Meat Science2000，56，： | 1 |
| 14 | Meta-analysis of the Hachinski Ischemic Score in pathologically verified dementias显示文摘 | Moroney JT Bagiella E Desmond DW | 1997 | Neurology1997，49，： | 1 |
| 15 | Improved survival of Lactobacilllts paracasei NFBC 338 in spray-dried powders containing gum acacia 显示文摘 | Desmond C Ross R P O'callaghan E | 2002 | Journal of Applied Microbiology2002，93，： | 1 |
| 16 | Reducing salt : A challenge for the meat industry显示文摘 | Desmond E | 2006 | Meat Science2006，，74： | 1 |
| 17 | Discovery of epigenetically silenced genes in acute myeloid leukemias显示文摘 | Desmond JC Raynaud S Tung E | 2007 | Leukemia2007，21，： | 1 |
| 18 | Improved survival ofLactobacillus paracasei NFBC 338 in spray-dried powders containing gum acacia 显示文摘 | Desmond C Ross R P O'Callaghan E | 2002 | Journal of Applied Microbiology2002，93，： | 1 |
| 19 | Effect of some fat replacers on the release of volatile aroma compounds from low-fat meat products显示文摘 | Chevance F F V Farmer L J Desmond E M | 2000 | J Agric Food Chem2000，48，8： | 1 |
| 20 | The effects of tapioca starch,oat fibre and whey protein on the physical and sensory properties of low-fat beef burgers显示文摘 | Desmond E M Troy D J Buckley D J | 1998 | Lebensm Wiss u-Technol1998，，5： | 1 |
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