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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Vibration suppression of a large flexible spacecraft for on-orbit operation显示文摘Flexible appendages, such as solar panels, communication antennas and other large structures, are mounted on the base of a space robot and target satellite. The vibration of the flexible structure is excited by operations of a space manipulator. It is very challenging to control the vibration of large flexible appendages for on-orbit operation and, especially when the manipulator operates a non-cooperative target with unknown structural parameters and vibration information. In this study, a hybrid control method is proposed based on wave-based control and PD control methods to control the motion of a manipulator while suppressing the vibration of appendages. First, the rigid-flexible coupled dynamic model of a compounded system is established.This is followed by designing a hybrid control strategy combining wave-based control and PD control for restto-rest maneuvers based on the characteristics of the compounded system. Finally, the simulation of a 3D compounded system is provided to verify the effectiveness of the presented approach. The simulation results indicate that the space robot can successfully berth the target while suppressing the vibrations of the structure. | Deshan MENG Houde LIU Yanan LI Wenfu XU Bin LIANG | 2017 | Science China(Information Sciences)2017，60，5： | 6 |
| 3 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 4 | Vibration Measurement of Pedestrian Bridge Using Double Magnetic Suspension Vibrator Based on Wavelet Analysis显示文摘Aiming at the problem of pedestrian bridge vibration measurement,a vibration measurement system of pedestrian bridge with dual magnetic suspension vibrator structure was designed according to absolute vibration measurement principle. The relationship between the magnetic repulsion force of vibrator and its displacement was obtained by the experimental method and the least square fitting method. The vibration equations of two magnetic suspension vibrators were deduced respectively,and the measurement sensitivity of the system was deduced. The amplitude-frequency characteristic of the system was studied. A simulation model of vibrator measurement system with double magnetic suspension vibrator was established. The analysis shows that the sensitivity of the vibration measurement system with double magnetic suspension vibrator is higher than that with single magnetic suspension vibrator. The four vibration waveforms were measured,that is,no one passes through a pedestrian bridge,there are cars running under the pedestrian bridge,single pedestrian passes through the pedestrian bridge and multiple pedestrians pass through the pedestrian bridge. The multi-scale one-dimensional wavelet decomposition function was used to analyze the vibration signals. The vibration characteristics were obtained using one dimension wavelet decomposition function under four different conditions. Finally,the vibration waveforms of four cases were reconstructed. The measured results show that the vibration measurement system of pedestrian bridge with double magnetic suspension vibrator structure has high measurement sensitivity. The design has a certain value to monitor a pedestrian bridge. | JIANG Dong KONG Deshan ZHANG Zhengnan WANG Deyu | 2017 | Instrumentation2017，4，3： | 4 |
| 5 | The level of erbB2 expression predicts sensitivity to the cytotoxic effects of an intracellular anti-erbB2 sFv 显示文摘 | Deshane J Siegal GP | 1998 | J Mol Med1998，76，6： | 1 |
| 6 | Stromal cen-derived factor 1 promoles angiogenesis via a heme oxygenase 1-dependent mechanism 显示文摘 | Deshane J Chen S Caballero S | 2007 | J Exp Med2007，204，3： | 1 |
| 7 | An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2显示文摘 | Wright M Grim J Deshane J | 1997 | Gene Ther1997，4，31： | 1 |
| 8 | One-Step Preparation of Single-Crystalline β-MnO2 Nanotubes显示文摘 | Deshan Zheng Sixiu Sun Weiliu Fan | 2005 | J Phys Chem2005，109，16： | 1 |
| 9 | Refractory asthma: mechanisms, targets, and therapy显示文摘 | TREVOR JL DESHANE JS | 2014 | Allergy2014，69，7： | 1 |
| 10 | Chlorotoxin Inhibits Glioma cell Invasion via Matrix Metalloproteinase-2显示文摘 | Deshane J Garaener C C Sontheimer H | 2003 | J Biol Chem2003，278，： | 1 |
| 11 | Analysis to pore structure of typical semi-cokes by mercury porosimetry显示文摘 | Xing Deshan Yan Weiping | 2007 | Journal of North China Electric Power University:Natural Science2007，34，5： | 1 |
| 12 | Computerized patient anesthesia ecords: less time and better quality than manually produced anesthesia records显示文摘 | Deshane P Giles C | 1993 | J Clin Anesth1993，5，4： | 1 |
| 13 | Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2显示文摘 | Deshane J Garner C C Sontheimer H | 2003 | J Biol Chem2003，278，6： | 1 |
| 14 | Hypoxic preconditioning suppresses group HI secreted phos- pholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons 显示文摘 | Wang Guangsong Zhou Deshan Wang Changzheng | 2010 | J Neurochem2010，114，4： | 1 |
| 15 | Heme oxygenase-1 expres-sion in disease states 显示文摘 | Deshane J Wright M Agarwal A | 2005 | Acta Biochim Pol2005，52，2： | 1 |
| 16 | Gene therapy and ovarian cancer:A review显示文摘 | Barnes MN Deshane JS rosenfeld M | 1997 | Obstet Gynecol1997，89，1： | 1 |
| 17 | Heme oxygenase-1 and carbon monoxide in vascular pathobiology显示文摘 | Dulak J Deshane J Jozkowicz A | 2008 | Circulation2008，117，2： | 1 |
| 18 | Grain in- terface modification and magnetic properties of Nd-Fe-B sin- tered magnets 显示文摘 | Deshan Li Shunji Suzuki Takashi Kawasaki | 2008 | Japanese Journal of Applied Physics2008，47，10： | 1 |
| 19 | Distribution and possible role of PDGF-AA and PDGFR-α in the gastrointestinal tract of adult guinea pigs显示文摘 | Fangxiao Chan Yong Liu Haimei Sun Xiaoshuang Li Hongwei Shang Dongying Fan Jing An Deshan Zhou | 2010 | Virchows Archiv2010，，3： | 1 |
| 20 | Chlorotox ininhibits glioma cellinvasion via matrix metalloproteinase-2显示文摘 | Deshane J Gamer CC Sontheimer H | 2003 | J Biol Chem2003，278，： | 1 |
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