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| 1 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 2 | Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures显示文摘BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy. METHODS: Consecutive patients were included as follows: difficult stones(group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures(group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate(group 1) and diagnostic accuracy(group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1(n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15(71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17(81.0%) patients. One serious adverse event occurred(bile duct perforation). Group 2(n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures. | Athanasios D Sioulas Muhammad A El-Masry Stefan Groth Guido Schachschal Mario Anders Thomas Rosch Ulrike Denzer | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 2 |
| 3 | Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography显示文摘 | ZINGER O ANSELME K DENZER A HABERSETZER P WIELAND M JEANFILS J HARDOUIN P LANDOLT D | 2004 | Biomaterials2004，25，14： | 1 |
| 4 | Metabotropic glutamate mGlu1receptor mRNA expression in dorsal root ganglia of rats after peripheral nerve injury显示文摘 | Hofmann HA Siegling A Denzer D | 2001 | Eur J Pharmacol2001，429，13： | 1 |
| 5 | Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice显示文摘 | Schon M Denzer D Kubitza RC | 2000 | J Invest Dermatol2000，14，5： | 1 |
| 6 | Rela- tionship between fracture toughness, fracture path, and mi- crostructure of 7050 aluminum alloy: Part I Quantitative characterization显示文摘 | Deshpande N U Gokhale A M Denzer D K | 1998 | Metall Mater Trans A1998，29，4： | 1 |
| 7 | Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice 显示文摘 | Sch6n M Denzer D Kubitza RC | 2000 | J Invest Dermatol2000，114，5： | 1 |
| 8 | Relationship between fracture toughness, fracture path, and mierostructure of 7050 aluminum alloy, part I: quantitative characterization显示文摘 | DESHPANDE N U C OKHALE A M DENZER D K etal | 1998 | Metall Mater Trans A1998，29，： | 1 |
| 9 | Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathie pain 显示文摘 | Siegling A Hofmann HA Denzer D | 2001 | Eur J Pharmacol2001，415，： | 1 |
| 10 | Effect of a preoperative separation of platelets on the postoperative blood loss subsequent to extracorporeal circulation in open heart surgery 显示文摘 | Harke H Tanger D Ftirst- Denzer S | 1977 | Der Anaesthesist1977，26，2： | 1 |
| 11 | Relationship between fracture toughness,fracture path and microstructure of 7050 aluminum alloy (Part Ⅰ):Quantitative characterization显示文摘 | Deshpasde N Q Gorhale A M Denzer D K | 1998 | Metall Trans A1998，29，4： | 1 |
| 12 | Pericyte involvement in capillary spronting during angiogenesis in situ显示文摘 | Denzer K Drenckhahn D | 1992 | Cell Tissue Res1992，270，： | 1 |
| 13 | Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice显示文摘 | Schon M Denzer D Kubitza RC et ol | 2000 | J Invest Dermatol2000，114，5： | 1 |
| 14 | Pericyte involve- ment in capillary sprouting during angiogenesis in situ 显示文摘 | NEHLS V DENZER K DRENCKHAHN D | 1992 | Cell Tissue Res1992，270，3： | 1 |
| 15 | Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain显示文摘 | Hofmann H A De Vry J Siegling A Spreyer P Denzer D | 2003 | Eur J Pharmacol2003，470，12： | 1 |
| 16 | Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance 显示文摘 | Denzer C Thiere D Muche R | 2009 | J Clin Endocrinol Metab2009，94，10： | 1 |
| 17 | Subclinical and clinical hy- pothyroidism and non- alcoholic fatty liver disease: a cross - sectional study of a random population sample aged 18 to 65 years显示文摘 | Ludwig U Holzner D Denzer C | 2015 | BMC Endocrine Disorders2015，15，1： | 1 |
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