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| 1 | Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity. | Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 2 | 雌激素受体相关受体亚型在卵巢癌中的表达及其与预后的关系显示文摘目的探讨雌激素受体相关受体(ERRs)亚型α、β、γ在卵巢癌中的表达及其与预后的关系。方法激光共聚焦显微镜观察ERRα蛋白在卵巢癌细胞株SKOV3和OVCAR3细胞内的定位。RT-PCR技术检测33份卵巢癌组织以及12份正常卵巢组织中3种ERRs亚型的mRNA表达,并结合临床病理指标分析其预后情况。结果ERRα蛋白主要分布于SKOV3和OVCAR3细胞的细胞核内。卵巢癌组织中ERRαmRNA的阳性表达率(58%)和ERRγmRNA的阳性表达率(48%)显著高于正常卵巢组织(分别为17%和33%,P<0.05);ERRβmRNA的阳性表达率在卵巢癌组织和正常卵巢组织中都很低(分别为9%和0),两者比较,差异无统计学意义(P=0.795)。ERRαmRNA的阳性表达与卵巢癌的手术病理分期(r=0.639,P=0.017)、病理分级(r=0.520,P=0.022)呈正相关。ERRαmRNA阳性表达的卵巢癌患者,其中位数整体生存时间(19.0个月)明显短于ERRαmRNA阴性表达患者(31.5个月,P=0.015),但两者间的无瘤生存时间(分别为12.6和14.5个月)比较,差异无统计学意义(P=0.820);ERRγmRNA阳性表达患者的中位数无瘤生存时间(18.0个月)显著长于ERRγmRNA阴性表达患者(13.5个月,P=0.020),但两者间中位数整体生存时间(分别为23.4和19.6个月)比较,差异无统计学意义(P=0.093)。结论ERRα蛋白主要表达于卵巢癌细胞核内。ERRαmRNA高表达与卵巢癌患者的预后差有关,而ERRγmRNA高表达可能提示患者预后较好。 | 孙蓬明 魏丽惠 Jalid Sehouli Carsten Denkert 赵丹 高敏 孙秀丽 Werner Litchtenegger | 2005 | 中华妇产科杂志2005，40，8： | 6 |
| 3 | Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers 显示文摘 | Denkert C von Minckwitz G Brase JC | 2015 | J Clin Oncol2015，33，9： | 1 |
| 4 | Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma显示文摘 | Denkert C Kobel M Pest S | 2002 | Am J Pathol2002，160，3： | 1 |
| 5 | Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer 显示文摘 | Denkert C Loibl S Noske A | 2010 | J Clin Oneol2010，28，1： | 1 |
| 6 | Expression of secreted protein acidic and rich in cysteine (SPARC) in breast cancer and response to neoadjuvant chemotherapy显示文摘 | Lindner JL Loibl S Denkert C | 2015 | Ann Oncol2015，26，1： | 1 |
| 7 | CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival显示文摘 | Kristiansen G Denkert C Xchluns K | 2002 | American Journal of Pathology2002，161，： | 1 |
| 8 | Significance of cyclooxygenase - 2 and MDRI/P - glyco- protein coexpression in ovarian cancers 显示文摘 | Pawe Surowiak Verena Materna Carsten Denkert | 2006 | Cancer Let- ters2006，235，2： | 1 |
| 9 | Genetic alterations in epithelial ovarian tumors analyzed by comparative genomic hybridization显示文摘 | Hauptmann S Denkert C Koch I | 2002 | HumPathol2002，33，6： | 1 |
| 10 | Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma显示文摘 | Weichert W Denkert C Schmidt M | 2004 | Br J Cancer2004，90，4： | 1 |
| 11 | Elevated expression of cyclooxygenase - 2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma显示文摘 | Denkert C Winzer KJ Muller BM | 2003 | Cancer2003，97，12： | 1 |
| 12 | Quicklime pre-conditioning of sludge to be dewatered in centrifuges lowers disposal costs显示文摘 | Denkert R Retter E A | 1993 | Water Science Technology1993，28，1： | 1 |
| 13 | Effect of neoadjuvant anthracycline-taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the GeparTrio study显示文摘 | Huober J yon Minckwitz G Denkert C | 2010 | Breast Cancer Res Treat2010，124，1： | 1 |
| 14 | Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer显示文摘 | Denkert C Loibl S Noske A | | 0，，01： | 1 |
| 15 | Cytoplasmic CD24 expression in coloreetal cancer independ-ently correlateswith shortened patient survival 显示文摘 | Weichert W Denkert C Burkhardt M | 2005 | Clin Cancer Res2005，11，18： | 1 |
| 16 | Expression of estrogen re- ceptor related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells 显示文摘 | SUN P SEHOULI J DENKERT C | 2005 | J Mol Med2005，83，6： | 1 |
| 17 | Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue ? a GC-TOFMS based metabolomics study 显示文摘 | BUDCZIESJ DENKERT C MILLER B M | 2012 | BMC Genomics2012，13，1： | 1 |
| 18 | Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma显示文摘 | Weichert W Denkert C Schmidt M | 2004 | Br J Cancer2004，90，4： | 1 |
| 19 | Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma显示文摘 | Denkert C Winzer KJ Muller BM | 2003 | Cancer2003，97，12： | 1 |
| 20 | Polo-like kinase isoform expression is prongnostic factor in ovarian carcinoma显示文摘 | Weichert W Denkert C Schmidt M | 2004 | Br J Cancer2004，90，4： | 1 |
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