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| 1 | Pulmonary fibrosis and emphysema: Is the emphysema type associated with the pattern of fibrosis?显示文摘AIM: To investigate whether the predominant emphysema type is associated with the high resolution computed tomography(HRCT) pattern of fibrosis in combined pulmonary fibrosis and emphysema(CPFE).METHODS: Fifty-three smokers with upper lobe emphysema and lower lobe pulmonary fibrosis on- HRCT-were retrospectively evaluated. Patients were stratified into 3 groups according to the predominant type of emphysema: Centrilobular(CLE), paraseptal(PSE), CLE = PSE. Patients were also stratified into 3 other groups according to the predominant type of fibrosis on HRCT: Typical usual interstitial pneumonia(UIP), probable UIP and nonspecific interstitial pneumonia(NSIP). HRCTs were scored at 5 predetermined levels for the coarseness of fibrosis(Coarseness), extent of emphysema(emphysema), extent of interstitial lung disease(Tot Ext ILD), extent of reticular pattern not otherwise specified(Ret NOS), extent of ground glass opacity with traction bronchiectasis(extG GOBx), extent of pure ground glass opacity and extent of honeycombing. HRCT mean scores, pulmonary function tests, diffusion capacity(DLCO) and systolic pulmonary arterial pressure were compared among the groups.RESULTS: The predominant type of emphysema was strongly correlated with the predominant type of fibrosis. The centrilobular emphysema group exhibited a significantly higher extent of emphysema(P < 0.001) and a lower extent of interstitial lung disease(P < 0.002), reticular pattern not otherwise specified(P < 0.023), extent of ground glass opacity with traction bronchiectasis(P < 0.002), extent of honeycombing(P < 0.001) and coarseness of fibrosis(P < 0.001) than the paraseptal group. The NSIP group exhibited a significantly higher extent of emphysema(P < 0.05), total lung capacity(P < 0.01) and diffusion capacity(DLCO)(P < 0.05) than the typical UIP group. The typical UIP group exhibited a significantly higher extent of interstitial lung disease, extent of reticular pattern not otherwise specified, extent of ground glass opacity with traction bronchiectasis, extent of honeycombing and coarseness of fibrosis(0.039 > P > 0.000). Although the pulmonary arterial pressure was higher in typical UIP group relative to the NSIP group, the difference was not statistically significant.CONCLUSION: In CPFE patients, paraseptal emphysema is associated more with UIP-HRCT pattern and higher extent of fibrosis than centrilobular emphysema. | Anastasia Oikonomou Paraskevi Mintzopoulou Argyris Tzouvelekis Petros Zezos George Zacharis Anastasios Koutsopoulos Demosthenes Bouros Panos Prassopoulos | 2015 | World Journal of Radiology2015，7，9： | 2 |
| 2 | Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis显示文摘 | Katherine Esposito Paolo Chiodini Annalisa Capuano Giuseppe Bellastella Maria Ida Maiorino Concetta Rafaniello Demosthenes B. Panagiotakos Dario Giugliano | 2013 | Endocrine2013，，3： | 2 |
| 3 | Cigarette smoking and myocardial infarction in young men and women: A case-control study显示文摘 | Demosthenes B. Panagiotakos Loukianos S. Rallidis Christos Pitsavos Christodoulos Stefanadis Dimitrios Kremastinos | 2006 | International Journal of Cardiology2006，，3： | 2 |
| 4 | Consumption of fruits and vegetables in relation to the risk of developing acute coronary syndromes;the CARDIO2000 case-control study显示文摘 | Demosthenes BP Christos P Peter K | 2003 | Nutr J2003，10，8： | 1 |
| 5 | Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies显示文摘 | Maria G T Katerina L Demosthenes B | | 0，，01： | 1 |
| 6 | Low-voltage MOS linear transconductor/squarer and four-quadrant multiplier for analog VLSI显示文摘 | Demosthenous A Panovic M | 2005 | IEEE Transactions on Circuit and Systems-I:Regular Papers2005，52，9： | 1 |
| 7 | A CMOS analog winner-takes-all network for large-scale applications显示文摘 | DEMOSTHENOUS A SMEDLEY S TAYLOR J | 1998 | IEEE Transactions on Circuits and Systems:ⅠFundamental Theory and Applica-tions1998，45，3： | 1 |
| 8 | Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment 显示文摘 | Antoniades C Demosthenous M Reilly S | 2012 | J Am Coll Cardiol2012，59，1： | 1 |
| 9 | Intensive care unit-acquired infection as a side effect of sedation显示文摘 | Saad N Demosthenes M Daniel M | 2010 | Crit Care2010，14，2： | 1 |
| 10 | Effect of Continuous Positive Airway Pressure Treatment on Serum Cardiovascular Risk Factors in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome显示文摘 | Paschalis Steiropoulos Venetia Tsara Evangelia Nena Christina Fitili Margarita Kataropoulou Marios Froudarakis Pandora Christaki Demosthenes Bouros | 2007 | Chest2007，，： | 1 |
| 11 | Method- ological issues in the quantitative assessment of quality of life显示文摘 | DEMOSTHENES B PANAGIOTAKO S JOHN N | 2011 | Angiology2011，62，25： | 1 |
| 12 | Involvement of lymphatic metastatic spread in non-small cell lung cancer accordingly to the primary cancer location显示文摘 | Christophoros S. Kotoulas Christophoros N. Foroulis Konstantinos Kostikas Marios Konstantinou Patra Kalkandi Maria Dimadi Demosthenes Bouros Achilles Lioulias | 2003 | Lung Cancer2003，，2： | 1 |
| 13 | Assoclarion of malignancy with diseases causing interstitial pulmonary changes显示文摘 | Demosthenes B Kostas Hatzakis Haris Labrakis | 2002 | Chest2002，121，4： | 1 |
| 14 | compact low-voltage CMOS four-quadrant analogue multiplier 显示文摘 | Sawigun C Demosthenous A | 2006 | Electron Lett2006，42，： | 1 |
| 15 | Dia nostic Value of Interleukin-1, Interleukin-6, and Tumor Necros1 Factor in Pleural Effusions 显示文摘 | Nektaria Xirouchaki tzanakis Demosthenes Bouros | 2002 | Chest2002，121，： | 1 |
| 16 | Innate and adaptive inflammation as a therapeutic target in vascular dis- ease:the emerging role of statins 显示文摘 | Tousoulis D Psarros C Demosthenous M | 2014 | J Am Coil Cardiol2014，63，23： | 1 |
| 17 | The association between oxidative stress and obstructive sleep apnea syndrome显示文摘 | Demosthenes Makris Melpomeni Ntalapascha Epaminondas Zakynthinos | 2013 | Sleep and Breathing2013，，2： | 1 |
| 18 | Wall Shear Stress: Theoretical Considerations and Methods of Measurement显示文摘 | Demosthenes Katritsis Lambros Kaiktsis Andreas Chaniotis John Pantos Efstathios P. Efstathopoulos Vasilios Marmarelis | 2007 | Progress in Cardiovascular Diseases2007，，5： | 1 |
| 19 | Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer显示文摘 | Demosthenes M Arnaud S Marie CC | 2007 | BMC Cancer2007，5，7： | 1 |
| 20 | Smoking induces lipopmtein-assoeiated phospholipnse A2 in cardi-ovascular disease free adults:the AT CA Study显示文摘 | Alexandres D Tselepis A Demosthenes B | 2010 | Ath-erosclerosis2010，16，2： | 1 |
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