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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom 显示文摘 | Demmers T GM Phillips V R Short L S | 2001 | Journal of Agricultural Engineering Research2001，79，1： | 1 |
| 3 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom显示文摘 | Demmers T G M Phillips VR Short L S | 2001 | Journal of Agricultural Engineering Research2001，，： | 1 |
| 4 | Assessment of techniques for measuring the ventilation rate using an experimen- tal building section 显示文摘 | T G M Demmers L R Burgess V R Phillips | 2000 | Journal of Agricultural Engineering Rese- arch2000，76，： | 1 |
| 5 | First experience with methods to measure ammonia emission from natural ventila- ted cattle buildings in the UK 显示文摘 | T G M Demmers L R Burgess J L Short | 1998 | Atmospheric Environment1998，32，： | 1 |
| 6 | Noonan syn- drome due to a SHOC2 mutation presenting with fetal dstress and fatal hypertrophic cardiomyopathy in a pre- mature infant显示文摘 | Hoban R Roberts AE Demmer L | 2012 | Am J Med Genet A2012，158，6： | 1 |
| 7 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom显示文摘 | Demmers T G M Phillips V R Short L S | 2001 | Journal of Agricultural Engineering Research2001，79，1： | 1 |
| 8 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom 显示文摘 | Demmers T G M Phillips VR Short L S | 2001 | Journal of Agricultural Engineering Research2001，79，1： | 1 |
| 9 | Respiratory com- plications of Ehlers- Danlos syndrome type IV 显示文摘 | DOWTON S B PINCOTF S DEMMER L | 1996 | Clin Gen- et1996，50，： | 1 |
| 10 | Respiratory complications of Ehlers-Danlos syndrome type IV 显示文摘 | Dowton S B Pincott S Demmer L | 1996 | Clin Genet1996，50，6： | 1 |
| 11 | The relationship between physical activity and leg health in the broiler chicken显示文摘 | SHERLOCK L DEMMERS T G M GOODSHIP A E | 2010 | British Poultry Science2010，51，1： | 1 |
| 12 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom显示文摘 | Demmers T G M Phillips V R Short L S | | 0，，： | 1 |
| 13 | The preferences of laying hens for different concentrations of atmospheric ammonia显示文摘 | KRISTENSEN H H BURGESS L R DEMMERS T G | 2000 | Appl Anim Behav Sci2000，68，4： | 1 |
| 14 | Sestructure and environment validation of ventilation rate measurement methods and the ammonia emission from naturally ventilated dairy and beef buildings in the united kingdom显示文摘 | DEMMERS T G M PHILLIPS V R SHORT L S | 2001 | J Agr Eng Res2001，79，1： | 1 |
| 15 | Review on Modern Advances of Chemical Methods for the Introduction of a Phosphonic Acid Group显示文摘 | Demmer C S Krogsgaard L N Bunch L | 2011 | Chem Rev2011，111，12： | 1 |
| 16 | Validation of ventilation rate measurement methods and ammonia emis- sion from naturally ventilated dairy and beef buildings in the United Kingdom 显示文摘 | Demmers T G M Phillips V R Short L S | 2001 | Journal of Agricultural Engineering Research2001，79，1： | 1 |
| 17 | Validation of ventilation rate measurement methods and ammonia emission from naturally ventilated dairy and beef buildings in the United Kingdom 显示文摘 | Demmers T G M Phillips V R Short L S | 2001 | Jour- nal of Agricultural Engineering Research2001，79，1： | 1 |
| 18 | Rat cellular retinol-binding protein 11 :use of a doned cDNA to define its primary structure,tissue-specific expression,and developmental regulation 显示文摘 | Li E Demmer L A Sweetser D A Ong D E Gordon J | 1986 | Proc NatL Acad Sci USA1986，83，： | 1 |
| 19 | The influence of anti- infective periodontal treatment on C-reactive protein: a sys- tematic review and meta-analysis of randomized controlled tri- als显示文摘 | Demmer RT Trinquart L Zuk A | 2013 | PLoS One2013，8，77： | 1 |
| 20 | Vali-dation of ventilation rate measurement methods andammonia emission from naturally ventilated dairy andbeef buildings in the United Kingdom显示文摘 | Demmers T G M Phillips V R Short L S | 2001 | Journal ofAgricultural Engineering Research2001，79，1： | 1 |
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