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10篇 您的检索式：作者名="Demets D L"

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		题名	作者	年代	出处	被引量
	1	Estimation of normal ranges and cumulative proportions by transforming observed distributions to gaussian form显示文摘	Harris E K Demets D L	1972	Clin Chem1972，18，：	1
	2	Utilization of ironmaking and steelmaking slags显示文摘	Mihok L Demeter P Baricova D	2006	Metalurgi- ja2006，45，3：	1
	3	Design and analysis of group sequential tests based on the type I error spending rate function 显示文摘	Lan K K G DeMets D L	1983	Biometrika1983，74，1：	1
	4	Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with Indinavir,Zidovudine and Lamivudine显示文摘	Demeter L M Hughers M D	2001	Annals of Internal Medicine2001，135，11：	1
	5	Interim analysis: the alpha spendingfunction approach显示文摘	Demets D L Lan K	1994	Stat Med1994，13，：	1
	6	Discrete sequential boundaries for clinical trials显示文摘	Lan K G DeMets D L	1983	Biometrika1983，70，3：	1
	7	Estimation of normal ranges and cumulative proportions by transforming observed distributions to gaussianform显示文摘	Harris E K Demets D L	1972	Clin Chem1972，，18：	1
	8	Update of the drug resistance mutations in HIV-1: special contribution-drug resistanlce mutations in HIV显示文摘	Johnson V A Brun-Vezinet F Clotet B Conway B D'Aquila R T Demeter L M	2004	Top HIV Med2004，12，：	1
	9	Methods for combining randomized clinical tri- als:Strengths and limitations 显示文摘	DEMETS D L	1987	Stat Med1987，6，3：	1
	10	Primary care providers should prescribe aspirin to prevent cardiovascular disease based on benefit−risk ratio,not age显示文摘Recent guidelines restricted aspirin(ASA)in primary prevention of cardiovascular disease(CVD)to patients<70 years old and more recent guidance to<60.In the most comprehensive prior meta-analysis,the Antithrombotic Trialists Collaboration reported a significant 12%reduction in CVD with similar benefit−risk ratios at older ages.Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,four trials were added to an updated meta-analysis.ASA produced a statistically significant 13%reduction in CVD with 95%confidence limits(0.83 to 0.92)with similar benefits at older ages in each of the trials.Primary care providers should make individual decisions whether to prescribe ASA based on benefit−risk ratio,not simply age.When the absolute risk of CVD is>10%,benefits of ASA will generally outweigh risks of significant bleeding.ASA should be considered only after implementation of therapeutic lifestyle changes and other drugs of proven benefit such as statins,which are,at the very least,additive to ASA.Our perspective is that individual clinical judgements by primary care providers about prescription of ASA in primary prevention of CVD should be based on our evidence-based solution of weighing all the absolute benefits and risks rather than age.This strategy would do far more good for far more patients as well as far more good than harm in both developed and developing countries.This new and novel strategy for primary care providers to consider in prescribing ASA in primary prevention of CVD is the same as the general approach suggested by Professor Geoffrey Rose decades ago.	Kyungmann Kim Charles H Hennekens Lisa Martinez J Michael Gaziano Marc A Pfeffer Bianca Biglione Alexander Gitin Jeanne Bell McCabe Thomas D Cook David L DeMets Sarah K Wood	2021	Family Medicine and Community Health2021，9，4：	0

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