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| 1 | Children in Disaster Risk Reduction in Portugal: Policies,Education,and (Non) Participation显示文摘International agencies and scientific research have been calling for the inclusion of children in disaster preparedness and risk reduction, to hear their voices in order to address their specific needs and vulnerabilities and harness their capabilities in terms of building community resilience. This article assesses the roles ascribed to children in policy and education for disaster risk reduction in Portugal. The approach is based on a scoping methodology that encompasses document analysis and interviews with national and local stakeholders and policymakers in the disaster risk reduction field. The research is carried out within the scope of a European funded project, CUIDAR Cultures of Disaster Resilience among Children and Young People. More specifically, the article provides an overview of the discourses on the roles ascribed to children in urban disaster risk reduction(DRR). The authors maintain that although children are often taken as a target group in urban disaster prevention and management, they are seldom considered in terms of active participation in disaster risk reduction programs in the Portuguese context. Nevertheless, our analysis shows that there is a growing awareness of the relevance of active participation by children in order to create successful DRR. | Ana Delicado ussara Rowland Susana Fonseca Ana Nunes de Almeida Luísa Schmidt Ana Sofia Ribeiro | 2017 | International Journal of Disaster Risk Science2017，8，3： | 2 |
| 2 | Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction显示文摘In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases.However,it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state.Here,we describe a versatile in vivo gene knock-in methodology that enables the targeting of a broad range of mutations and cell types through the insertion of a minigene at an intron of the target gene locus using an intracellularly linearized single homology arm donor.As a proof-of-concept,we focused on a mouse model of prematureaging caused by a dominant point mutation,which is difficult to repair using existing in vivo genome-editing tools.Systemic treatment using our new method ameliorated aging-associated phenotypes and extended animal lifespan,thus highlighting the potential of this methodology for a broad range of in vivo genome-editing applications. | Keiichiro Suzuki Mako Yamamoto Reyna Hernandez-Benitez Zhe Li Christopher Wei Rupa Devi Soligalla Emi Aizawa Fumiyuki Hatanaka Masakazu Kurita Pradeep Reddy Alejandro Ocampo Tomoaki Hishida Masahiro Sakurai Amy NNemeth Estrella Nunez Delicado Josep MCampistol Pierre Magistretti Pedro Guillen Concepcion Rodriguez Esteban Jianhui Gong Yilin Yuan Ying Gu Guang-Hui Liu Carlos Lopez-Otin Jun Wu Kun Zhang Juan Carlos Izpisua Belmonte | 2019 | Cell Research2019，29，10： | 2 |
| 3 | Another look at principal curves and surfaces 显示文摘 | DELICADO P | 2001 | Journal of Multivariate Analysis2001，77，1： | 1 |
| 4 | MLPA vs multiprobe FISH: comparison of two methods for the screening of subtelomeric rearrangements in 50 patients with idiopathic mental retardation 显示文摘 | Palomares M Delicado A Lapunzina P at al | 2006 | Clin Genet2006，69，3： | 1 |
| 5 | Another look at principal curves and surfaces显示文摘 | Delicado P | 2001 | Journal of Multivariate Analysis2001，7，1： | 1 |
| 6 | Simulta- neous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry显示文摘 | Villas-Boas S G Delicado D G Nielsen J | 2003 | Anal Biochem2003，322，： | 1 |
| 7 | Holtoram syndrome:characterization of a novel mutation显示文摘 | Fernandez GL Lapunzina BP Delicado NA | 2006 | Ann Pediatr2006，64，6： | 1 |
| 8 | P2X7 and P2YI3 purinergic receptors mediate intracellular calcium responses to BzA- TP in rat cerebellar astrocytes 显示文摘 | Carrasquero LM Delicado EG Bustillo D | 2009 | J Neurochem2009，110，： | 1 |
| 9 | ERK1/2 activation is involved in the neuroprotective action of P2YI3 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons 显示文摘 | Ortega F P6rez-Sen R Delicado EG | 2011 | Neuropharmacology2011，61，： | 1 |
| 10 | Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography -mass spectrometry 显示文摘 | Silas Granato Villas-Boas Daniel Gutierrez Delicado Mats Akesson | 2003 | Analytical Biochemistry2003，322，： | 1 |
| 11 | Living on the mountains: patterns and causes of diversification in the springsnail subgenus Pseudamnicola (Corrosella) (Mollusca : Caenogastropoda : Hydrobiidae) 显示文摘 | Delicado D Machordom A Ramos MA | 2013 | Mol Phylogenet Evol2013，68，3： | 1 |
| 12 | Another Look at Principal Curves and Surfaces显示文摘 | Delicado P | 2001 | Journal of Multivariate Analysis2001，77，： | 1 |
| 13 | Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry显示文摘 | Villas-B as S G Delicado DG | 2003 | Analytical Biochemistry2003，322，： | 1 |
| 14 | Another look at principal curves and surfaces 显示文摘 | Delicado P | 2001 | Journal of Multivariate Analysis2001，77，1： | 1 |
| 15 | Ordinary kriging for function-valuedspatial data显示文摘 | Giraldo R Delicado P Mateu J | 2011 | Environmental and Ecological Statistics2011，18，3： | 1 |
| 16 | Another look at principal curves and surfaces 显示文摘 | Delicado P | 2001 | Journal of Multivariate Analysis2001，77，1： | 1 |
| 17 | Simultaneous analysis of amino and nonamino organic acids as methyl chloroformate derivatives using gas chromatography-mass spectrometry显示文摘 | Villas-Boas S G Delicado D G Akesson M | | 0，，01： | 1 |
| 18 | Measuring non-linear dependence for two random variables distributed along a curve 显示文摘 | DELICADO P SMREKAR M | 2009 | Statistics and Computing2009，19，3： | 1 |
| 19 | Another look at principal curves and surfaces 显示文摘 | DELICADO P | 2001 | Journal of Multivariate Analysis2001，77，1： | 1 |
| 20 | Principal Curves of Oriented Points:Theoretical and Computational Improvements显示文摘 | Delicado P Huerta M | 2003 | Computational Statistics2003，18，2： | 1 |
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