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	题名	作者	年代	出处	被引量
1	Parental transmission of type 2 diabetes mellitus in a highly endogamous population显示文摘AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes.	Abdulbari Bener Mohammad T Yousafzai Abdulla OAA Al-Hamaq Abdul-Ghani Mohammad Ralph A DeFronzo	2013	World Journal of Diabetes2013，4，2：	28
2	Nephropathy in diabetes 显示文摘	Molitch M E DeFronzo R A Franz M J	2004	Diabetes Care2004，27，1：	2
3	Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type显示文摘	Miyazaki Y DeFronzo RA	2009	Cardiovase Diabetol2009，8，：	1
4	Efficacy and tolerability of the DPP4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type-2 diabetes 显示文摘	DEFRONZO R A BURANT C F FLECK P	2012	J Clin Endocrinol Metab2012，97，5：	1
5	From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus显示文摘	Defronzo RA Banting Lecture	2009	Diabetes2009，58，4：	1
6	Pharmacologic therapy for type 2 diabetes mellitus显示文摘	DeFronzo RA	1999	Ann Intern Med1999，131，4：	1
7	The effect of insulin on renal sodium metabolism: a review with clinical implications 显示文摘	DeFronzo RA	1981	Diabetologia1981，21，2：	1
8	Effects of exenatide(exendin- 4) on glycemic control and weight over 30 weeks in meffonnin-treated patients with type 2 diabetes显示文摘	DeFronzo RA Ratner RE Han J	2005	Diabetes Care2005，28，5：	1
9	Impaired fasting glucose and impaired glueosetoleranee: implications for care 显示文摘	Nathan DM Davidson MB DeFronzo RA	2007	Diabetes Care2007，30，3：	1
10	Pharmacologic therapy for type 2 diabetes mellitus 显示文摘	DeFronzo RA	1999	Ann Intern Med1999，131，4：	1
11	Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists pro- vide a rational therapeutic approach 显示文摘	Bays H L Mandarino R A DeFronzo	2004	J Clin Endocrinol Metab2004，89，2：	1
12	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglyeemic insulin clamp显示文摘	Matsuda M DeFronzo RA	1999	Diabetes Care1999，22，：	1
13	Contributions ofβcell dysfunction and insulin resistance to the pathogenesis of IGT and IFG显示文摘	Abdul-Ghani MA Tripathy D DeFronzo RA		0，，05：	1
14	Ne- phropathy in diabetes 显示文摘	Moliteh ME DeFronzo RA Franz MJ	2004	Diabetes Care2004，27，1：	1
15	Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance显示文摘	Haus JM Kashyap SR Kasumov T Zhang R Kelly KR Defronzo RA	2009	Diabetes2009，58，2：	1
16	Effect of physical training on insulin action in obesity显示文摘	Defronzo Robert S	1987	Diabetes1987，36，：	1
17	Glucose toxicity ( review ) 显示文摘	ROSSETTI L GIACCARI A DEFRONZO RA	1990	Diabeties Care1990，13，6：	1
18	Efficacy andsafety of SGLT2 inhibitors in the treatment of type 2 dia-betes mellitus显示文摘	Abdul-Ghani MA Norton L DeFronzo RA	2012	Curr Diab Rep2012，12，3：	1
19	Assessment and treatment of cardiovascular risk in prediabetes : impaired glucose tolerance and impaired fasting glucose显示文摘	DeFronzo RA Abdul-Ghani M	2011	Am J Cardiol2011，108，：	1
20	Glucose clamp technique a method for quantifying insulin secretion and resistance显示文摘	DeFronzo RA Tobin JD Andres R		0，，：	1

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