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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Inferior vena cava interruption : how and when显示文摘 | Cirard P Tardy B decousus H | 2002 | Annu Rev Med2002，51，1： | 1 |
| 3 | Inferior vena cava interruption: how and when显示文摘 | Girard P Tardy B Decousus H | 2000 | Ann Rev Med2000，51，1： | 1 |
| 4 | Thrombophilia and risk of venous thrombosis in patients with cancer显示文摘 | Decousus H Moulin N Quenet S | 2007 | Thromb Res2007，1202，： | 1 |
| 5 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis显示文摘 | Decousus H Leizorovicz A Parent F | 1998 | N Engl J Med1998，33，： | 1 |
| 6 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep- vein thrombosis 显示文摘 | DECOUSUS H LEIZOROVICZ A PARENT F | 2001 | N Engl J Med2001，338，： | 1 |
| 7 | Fondaparinux for the treatment of superficial-vein thrombosis in the legs显示文摘 | Decousus H Prandoni P Mismetti P | 2010 | N Engl J Med2010，363，13： | 1 |
| 8 | Inferior vena eava in- terruption: how and when? 显示文摘 | Girard P Tardy B Decousus H | 2000 | Annu Rev Med2000，51，5： | 1 |
| 9 | Inferior vena cava interruption: how and when 显示文摘 | Girard P Tardy B Decousus H | 2000 | Annu Rev Med2000，51，： | 1 |
| 10 | Inferior vena cava interruption: how and when 显示文摘 | Girard P Tardy B Decousus H | 2000 | Annu Rev Med2000，51，1： | 1 |
| 11 | Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism显示文摘 | Buller HR Davidson BL Decousus H | 2003 | N Engl J Med2003，349，18： | 1 |
| 12 | Inferior vena cava interruption: how and when显示文摘 | Girard P Tardy B Decousus H | 2000 | Ann Rev Med2000，51，： | 1 |
| 13 | Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism:findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry显示文摘 | Laporte S Mismetti P Decousus H | | 0，，： | 1 |
| 14 | Inferior Vena Cava Interruption: How and When?显示文摘 | Philippe Girard Bernard Tardy Herve Decousus | 2000 | Annual Review of Medicine2000，，： | 1 |
| 15 | Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis:arandomized trial 显示文摘 | Buller HR Davidson BL Decousus H | 2004 | Ann Intern Med2004，140，11： | 1 |
| 16 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis显示文摘 | Decousus H Leizorovicz A Parent F | 1998 | N Engl J Med1998，338，7： | 1 |
| 17 | Fondaparinux forthe treat- ment of superficial---vein thrombosis in the legs显示文摘 | Decousus H Prandoni P Mismetti P et a1 | 2010 | N Engl J Med2010，363，13： | 1 |
| 18 | Fondaparinux or enoxaparin for the initial treatment of symptoma tic deep venoas thrombosis:a randomized trial显示文摘 | Bailer HR Davidson BL Decousus H | 2004 | Ann Intern Med2004，140，： | 1 |
| 19 | Edoxaban versuswarfarin for the treatment of symptomatic venous thromboembolism显示文摘 | Buller HR Decousus H Grosso MA | 2013 | N EngI J Med2013，369，15： | 1 |
| 20 | A clinical trial of vena caval filters in theprevention of pulmonary embolism in patients with proximal deep-vein thrombosis显示文摘 | Decousus H Leizorovicz A Paven F | 1998 | N EnglJ ned1998，338，： | 1 |
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