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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 3 | Surveillance for antimicrobial susceptibility among clinical isolates of Pseudomonas aeruginosa and Acinetobater baumanni from hospitalized patients in the United States,1998 to 2001显示文摘 | Karlowsky JA Deborah C | 2003 | Antimictob Agents Chemother2003，47，5： | 1 |
| 4 | Flavonoid profil- ing and biosynthetic gene expression in flesh and peel of two tomato genotypes grown under U'V-B-depleted conditions during ripening显示文摘 | DEBORAH G VALERIO L VALENTINA C | 2008 | Journal of Agricultural and Food Chemistry2008，56，14： | 1 |
| 5 | Real-time reverse transeription-polymerase chain reaction assays for the detection and differentiation of North American swine influenza viruses 显示文摘 | Jurgen A R Kelly M L Deborah F C | 2004 | J Vet Diagn Invest2004，16，： | 1 |
| 6 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 7 | Microbial transformation of alkaloids 显示文摘 | Deborah A Rathbone Neil C Bruce | 2002 | Ecology and industry microbiology2002，，5： | 1 |
| 8 | The Relation between Systematic Reviews and Practice Guidelines显示文摘 | Nancy L G Gray Ellrodt | 1997 | Annal of Internal Medicine1997，127，3： | 1 |
| 9 | Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses显示文摘 | Deborah C | 2006 | Am J Physiol Heart Circ Physiol2006，291，6： | 1 |
| 10 | Wine tourism developmeat and marketing strategies in Southwest Michigan显示文摘 | Astrid W Deborah C | | 0，，01： | 1 |
| 11 | Bioeompatibility of methyleellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury 显示文摘 | Matthew C T Deborah A S Stuart W H | 2001 | Biomaterials2001，22，： | 1 |
| 12 | Radioprotectors and Mitigators o{ Radiation-Induced Normal Tissue Inju ry显示文摘 | Deborah C Ana PC Fuminori H | 2010 | Oncologist2010，15，4： | 1 |
| 13 | 显示文摘 | David M P Lawrence F D Deborah G C | 2004 | J Am Chem Soc2004，126，14： | 1 |
| 14 | Minimizing risks associated with peripherally insert- ed central catheters in the NICU 显示文摘 | Deborah C | 2001 | Am J Ma/ern Child Nuts2001，26，1： | 1 |
| 15 | Polyoxometalates in Medicine显示文摘 | Rhule J T Hill C L Deborah A Judd | 1998 | Chem Rev1998，98，： | 1 |
| 16 | Minimizing risks associated with peripherally inserted central catheters in the NICU显示文摘 | Deborah C | | 0，，01： | 1 |
| 17 | Controlled expression and functional analysis of iron- sulfur cluster biosynthetic components with Azotobacter vinelandii显示文摘 | Deborah C Johnson Mihaela-Carmen Unciuleac Dennis R Dean | 2006 | Journal of Bacteriology2006，，： | 1 |
| 18 | Ascent:adaptive selfconfiguring sensor networks topologies显示文摘 | ALBERTO C DEBORAH E | 2004 | IEEE Trans on Mobile Computing2004，3，3： | 1 |
| 19 | Uneven distribution of MHC class Ⅱ epitopes within the influenza virus显示文摘 | Sherry R Corowe Shannon C Miller Deborah M Brown | | 0，，24： | 1 |
| 20 | Dysthy-mia and depression increase risk of dementia and mortalityamong older veterans 显示文摘 | AMY L B KENNETH E C DEBORAH E B | 2012 | Am J Geriat Psychiat2012，20，8： | 1 |
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