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| 1 | Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity显示文摘With the internationally growing popularity of traditional Chinese medicine(TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephritis. Transporters in renal proximal tubule are believed to be critical in the disposition of xenobiotics. In this review, we provide information on the alteration of renal transporters by nephrotoxic TCMs, which may be helpful for understanding the nephrotoxic mechanism of TCMs and reducing adverse effects. Studies have proven that when administering nephrotoxic TCMs, the expression or function of renal transporters is altered, especially organic anion transporter 1 and 3. The alteration of these transporters may enhance the accumulation of toxic drugs or the dysfunction of endogenous toxins and subsequently sensitize the kidney to injury.Transporters-related drug combination and clinical biomarkers supervision to avoid the risk of future toxicity are proposed. | SHEN Qing-Qing WANG Jing-Jing ROY Debmalya SUN Li-Xin JIANG Zhen-Zhou ZHANG Lu-Yong HUANG Xin | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 11 |
| 2 | Effect of pioglitazone on nerve conduction velocity of the median nerve in the carpal tunnel in type 2 diabetes patients显示文摘AIM To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients.METHODS The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group(14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo.RESULTS At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8.5 interquartile range(IQR) = 6.5 to 11.5) vs non-pioglitazone 14.5(IQR 10.5 to 18.75)](P = 0.002). Non-pioglitazone category displayed amelioration in amplitude in the sensory median nerve [baseline 13(IQR = 9 to 16.25) vs 3 mo 8.5(IQR = 6.5 to 11.5)](P = 0.01) and amplitude in motor median nerve [baseline 9(IQR = 4.75 to 11) vs 3 mo 6.75(IQR = 4.75 to 10.25)](P = 0.049); and deterioration of terminal latency of in motor ulnar nerve [baseline 2.07(IQR = 1.92 to 2.25) vs 3 mo 2.16(IQR = 1.97 to 2.325)](P = 0.043). There was amelioration of terminal latency in sensory ulnar nerve [baseline 2.45(IQR = 2.315 to 2.88) vs 3 mo 2.37(IQR = 2.275 to 2.445) for pioglitazone group(P = 0.038).CONCLUSION Treatment with pioglitazone accentuates probability of compressive neuropathy. In spite of comparable glycemic control over 3 mo, patients treated with pioglitazone showed superior electrophysiological parameters for the ulnar nerve. Pioglitazone has favourable outcome in nerve electrophysiology which was repealed when the nerve was subjected to compressive neuropathy. | Sudip Chatterjee Debmalya Sanyal Sourav Das Choudhury Mili Bandyopadhyay Suraj Chakraborty Arabinda Mukherjee | 2016 | World Journal of Diabetes2016，7，19： | 3 |
| 3 | 肿瘤相关脂肪细胞及其分泌因子:抗肿瘤药物潜在靶点显示文摘研究表明,肿瘤的发生发展与肿瘤微环境中的脂肪组织有着密切关系。肿瘤相关脂肪细胞及其分泌的脂质、脂肪因子、炎性因子、激素等,是肿瘤微环境中脂肪组织的主要成分,通过影响肿瘤细胞的能量代谢或者直接干涉肿瘤细胞信号通路,在肿瘤的发生、增殖、侵袭、转移等方面扮演重要角色。综述肿瘤相关脂肪细胞及其分泌的脂质、脂肪因子、炎性因子等对肿瘤细胞的影响以及靶向肿瘤相关脂肪细胞分泌因子的肿瘤治疗策略,为临床肿瘤靶向药物开发提供参考。 | DEBMALYA Roy 高颖生 孙立 袁胜涛 | 2017 | 药学进展2017，41，4： | 2 |
| 4 | Organizational identification among global virtual team members: The role of individualism-collectivism and uncertainty avoidance显示文摘 | Debmalya Mukherjee Susan C. Hanlon Ben L. Kedia Prashant Srivastava | 2012 | Cross Cultural Management: An International Journal2012，，4： | 1 |
| 5 | Inverse mapping of magnetic flux leakage signal for defect characterization显示文摘 | Debmalya Mukherjee S. Saha S. Mukhopadhyay | 2012 | NDT and E International2012，，： | 1 |
| 6 | Effect of Marsdenia tenacissima extract on G2/M cell cycle arrest by upregulating 14-3-3σ and downregulating c-myc in vitro and in vivo显示文摘Objective: Marsdenia tenacissima extract(MTE) is a traditional Chinese herbal medicine with anti-cancer activity. In some previous studies, different mechanism actions of the anti-cancer effect of MTE have been revealed. In this study, we first observed that MTE exhibited G2/M cell cycle arrest on two different human breast cancer cell lines, MDA-MB-231 and MCF-7 by mediating 14-3-3σ and c-myc.Methods: The effect of MTE on G2/M cell cycle arrest was evaluated in MDA-MB-231 and MCF-7 cell lines. MTT assay was done for evaluation of cell viability. Flow cytometry was employed for cell cycle analysis. Western blotting analysis and immunohistochemistry were performed to analyze the expression of G2/M cell cycle-related key protein in cells and tissue samples. Animal studies have been conducted to elucidate the anti-tumor effect of MTE.Results: Cell cycle is the backbone for developing cancer. Cell cycle proteins play a major role in the progression of cell cycle and cell proliferation. However, some key protein directly or indirectly modulate the action of cell cycle protein that highly affect cell cycle regulation. In order to investigate cellular proliferation of cancer, we observed that MTE induced the upregulation of 14-3-3σ and downregulation of c-myc,and then reduced the expression of G2/M cell cycle associated key protein, leading to the inhibition of cellular entry into mitosis phase. We also confirmed that MTE exerted a significant antitumor effect on the MDA-MB-231 xenograft model in vivo.Conclusion: G2/M cell cycle arrest occurred by the action of MTE, mediated by the upregulation of 14-3-3σ as well as downregulation of c-myc in MDA-MB-231 and MCF-7 cell lines. | Li Sun Qurat UI Ain Ying-sheng Gao Ghulam Jilany Khan Sheng-tao Yuan Debmalya Roy | 2019 | Chinese Herbal Medicines2019，11，2： | 1 |
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