| 1 | Review on the phosphate-based conversion coatings of magnesium and its alloys显示文摘Magnesium(Mg)and its alloys are lightweight as well as biocompatible and possess a high strength-to-weight ratio,making them suitable for many industries,including aerospace,automobile,and medical.The major challenge is their high susceptibility to corrosion,thereby limiting their usability.The considerably lower reduction potential of Mg compared to other metals makes it vulnerable to galvanic coupling.The oxide layer on Mg offers little corrosion resistance because of its high porosity,inhomogeneity,and fragility.Chemical conversion coatings(CCs)belong to a distinct class because of underlying chemical reactions,which are fundamentally different from other types of coating.Typically,a CC acts as an intermediate sandwich layer between the base metal and an aesthetic paint.Although chromate CCs offer superior performance compared to phosphate CCs,yet still they release carcinogenic hexavalent chromium ions(Cr^(6+));therefore,their use is prohibited in most European nations under the Registration,Evaluation,Authorization and Restriction of Chemicals legislation framework.Phosphate-based CCs are a cost-effective and environment-friendly alternative.Accordingly,this review primarily focuses on different types of phosphate-based CCs,such as zinc,calcium,Mg,vanadium,manganese,and permanganate.It discusses their mechanisms,current status,pretreatment practices,and the influence of various parameters-such as pH,temperature,immersion time,and bath composition-on the coating performance.Some challenges associated with phosphate CCs and future research directions are also elaborated. | Debasis Saran Atul Kumar Sivaiah Bathula David Klaumünzer Kisor K Sahu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 2 |
| 2 | 基于聚乳酸羟乙酸共聚物的青蒿琥酯纳米颗粒的制备,及其抗疟活性和毒性评价(英文)显示文摘目的:为疟疾治疗制定基于聚合物的青蒿琥酯纳米粒。创新点:以聚乳酸羟乙酸共聚物(PLGA)为载体,制备青蒿琥酯纳米颗粒。并以小鼠为模型,评估其抗疟疗效和安全性。方法:以PLGA为载体,采用从单一的水包油乳剂中进行溶剂蒸发的方法制备青蒿琥酯纳米颗粒。借助X射线衍射和差示扫描量热分析对纳米颗粒进行表征。以4 mg/kg的剂量对感染疟原虫的雄性瑞士白化小鼠进行体内抗疟活性的研究,测定血液和肝毒性的相关指标。体外实验以小鼠腹腔巨噬细胞细胞系RAW 264.7为模型,在7.8~1000μg/ml浓度范围内,测定游离型和包裹型青蒿琥酯的细胞毒性。结论:实验结果表明,纳米颗粒的粒径为(329.3±21.7)nm,包封率为(38.4±10.1)%。与游离青蒿琥酯(58.2%)相比,基于PLGA的青蒿琥酯纳米颗粒(Art-PLGA)具有较高的抑虫率(62.6%),P<0.05。就血小板计数结果而言,对照组(305 000.00±148 492.40)明显地高于游离青蒿琥酯组(139 500.00±20 506.10)和Art-PLGA组(163 500.00±3535.53),P<0.05。因此,药物的使用没有导致肝毒性的产生。体外细胞毒性试验结果表明,Art-PLGA的半数抑制浓度(IC50,468.0μg/ml)显著高于游离青蒿琥酯(7.3μg/ml),P<0.05。基于PLGA的青蒿琥酯纳米颗粒是一种有效安全的抗疟治疗方法。 | Kabiru DAUDA Zulaikha BUSARI Olajumoke MORENIKEJI Funmilayo AFOLAYAN Oyetunde OYEYEMI Jairam MEENA Debasis SAHU Amulya PAND A | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，11： | 1 |
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