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| 1 | Injection of bone marrow mesenchymal stem cells by intravenous or intraperitoneal routes is a viable alternative to spinal cord injury treatment in mice显示文摘In spite of advances in surgical care and rehabilitation,the consequences of spinal cord injury(SCI)ar still challenging.Several experimental therapeutic strategies have been studied in the SCI field,and recen advances have led to the development of therapies that may act on the inhibitory microenvironment.As sorted lineages of stem cells are considered a good treatment for SCI.This study investigated the effect o systemic transplantation of mesenchymal stem cells(MSCs)in a compressive SCI model.Here we presen results of the intraperitoneal route,which has not been used previously for MSC administration after comveI.WeafC57BL/6nt lmy atb spinal cord compression for 1 minute with a 30-g vascular clip.The animals were divided into five groups DMEM at 7 days after SCI),DMEM i.v.(intravenous injection of 500μL of DMEM at 7 days after SCI)The effects of MSCs transplantation in white matter sparing were analyzed by luxol fast blue staining.Th number of preserved fibers was counted in semithin sections stained with toluidine blue and the presenc of trophic factors was analyzed by immunohistochemistry.In addition,we analyzed the locomotor perfor mance with Basso Mouse Scale and Global Mobility Test.Our results showed white matter preservation and a larger number of preserved fibers in the MSC groups than in the DMEM groups.Furthermore,th MSC groups had higher levels of trophic factors(brain-derived neurotrophic factor,nerve growth factor neurotrophin-3 and neurotrophin-4)in the spinal cord and improved locomotor performance.Our result indicate that injection of MSCs by either intraperitoneal or intravenous routes results in beneficial out comes and can be elected as a choice for SCI treatment. | Bruna dos Santos Ramalho FernANDa Martins de Almeida Conrado Mendonca Sales Silmara de Lima Ana Maria Blanco Martinez | 2018 | Neural Regeneration Research2018，13，6： | 12 |
| 2 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 3 | Role of pancreatography in the endoscopic management of encapsulated pancreatic collections-review and new proposed classification显示文摘Pancreatic fluids collections are local complications related to acute or chronic pancreatitis and may require intervention when symptomatic and/or complicated.Within the last decade,endoscopic management of these collections via endoscopic ultrasound-guided transmural drainage has become the gold standard treatment for encapsulated pancreatic collections with high clinical success and lower morbidity compared to traditional surgery and percutaneous drainage.Proper understanding of anatomic landmarks,including assessment of the main pancreatic duct and any associated lesions–such as disruptions and strictures-are key to achieving clinical success,reducing the need for reintervention or recurrence,especially in cases with suspected disconnected pancreatic duct syndrome.Additionally,proper review of imaging and anatomic landmarks,including collection location,are pivotal to determine type and size of pancreatic stenting as well as approach using long-term transmural indwelling plastic stents.Pancreatography to adequately assess the main pancreatic duct may be performed by two methods:Either non-invasively using magnetic resonance cholangiopancreatography or endoscopically via retrograde cholangiopancreatography.Despite the critical need to understand anatomy via pancrea tography and assess the main pancreatic duct,a standardized approach or uniform assessment strategy has not been described in the literature.Therefore,the aim of this review was to clarify the role of pancreatography in the endoscopic management of encapsulated pancreatic collections and to propose a new classification system to aid in proper assessment and endoscopic treatment. | Igor Mendonca Proença Marcos Eduardo Lera dos Santos Diogo Turiani Hourneaux de Moura Igor Braga Ribeiro Sergio Eiji Matuguma Spencer Cheng Thomas R McCarty Epifanio Silvino do Monte Junior Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2020 | World Journal of Gastroenterology2020，26，45： | 3 |
| 4 | Long-term potentiation observed upon blockade of adenosine A1 in rat hippocampus is NMDAR-dependent显示文摘 | Ribeiro JA | 2000 | Neurosci Lett2000，291，2： | 1 |
| 5 | Ge- netic identification of lamniform and earcharhiniform sharks using multiplex - PCR 显示文摘 | Mendonca F F Hashimoto D T De - Franco B | 2010 | Conser- Genet Re- sour2010，2，1： | 1 |
| 6 | Human papillo- mavirus cervical infection: viral genotyping and risk factors for high - grade squamous intraepithelial lesion and cervix cancer 显示文摘 | de Mendonca VG Guimarges MJ de Lima Filho JL | 2010 | Rev Bras Ginecol Obstet2010，32，10： | 1 |
| 7 | Er: YAG laser, ultrasonic system, and curette produce different profiles on dentine root surfaces: an in vitro study显示文摘 | de Mendonca AC Maximo MB RodriguesJA | 2008 | Photomed Laser Surg2008，26，2： | 1 |
| 8 | Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score显示文摘 | de Mendonca A Vincent JL Suter PM | 2000 | Intens Care Med2000，26，7： | 1 |
| 9 | Bioconversionof apple pomace into a nutritionally enriched substrate by Candi-da utilis and Pleurotus ostreatus显示文摘 | Villas-Boas S G Esposito E de Mendonca M M | 2003 | World Journal of Microbiolo-gy&Biotechnology2003，19，5： | 1 |
| 10 | Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study显示文摘 | Jean-Louis Vincent Arnaldo de Mendonca Francis Cantraine Rui Moreno Jukka Takala Peter M. Suter Charles L. Sprung Francis Colardyn Serge Blecher | 1998 | Critical Care Medicine1998，，11： | 1 |
| 11 | Major peptides from amaranth (Amaranthus cruentus ) protein inhibit HMG- CoA reductase activity显示文摘 | Soares RA Mendonca S de Castro L | 2015 | Int J Mol Sci2015，16，： | 1 |
| 12 | Circulating levels of maemphage migration inhibitory faetor are associated witIl mild puhnonary dysfunction after cardiopulmonary bypass显示文摘 | Comes RV de Almeida Campos LA | 2004 | Shock2004，22，6： | 1 |
| 13 | Time course of platelet counts in critically ill patients 显示文摘 | AKCA S HAJI MICHAEL P DE MENDONCA A | 2002 | Crit Care Med2002，30，4： | 1 |
| 14 | Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units:results of a multicentric,prospective study显示文摘 | Vincent JL De Mendonca A Cantraine F | 1998 | Crit Care Med1998，26，： | 1 |
| 15 | Time course of platelet counts in critically ill patients显示文摘 | Akca S Haji-Michael P de Mendonca A | 2002 | Crit Care Med2002，30，4： | 1 |
| 16 | Efficacy of sodium hypochlorite and coconut soap used as disinfecting agents in the reduction of denture stomatitis, Streptococcus mutans and Candida albicans显示文摘 | de Mendonca Neto T | 2004 | J Oral Rehabil2004，31，5： | 1 |
| 17 | Time course of platelet counts in critically ill patients 显示文摘 | Akca S Haji-Michael P de Mendonca A | 2002 | Crit Care Med2002，30，4： | 1 |
| 18 | Adenosine re- ceptors in the nervous system: pathophysiological implicat- ions显示文摘 | Ribeiro JA Sebastiao AM De Mendonca A | 2003 | Prog Neurobiol2003，68，6： | 1 |
| 19 | Effect of vitamin C supplements on urinary oxalate and pH in calcium stone -forming patients 显示文摘 | Baxmann AC De 0 G Mendonca Heilberg IF | 2003 | Kidney Int2003，63，3： | 1 |
| 20 | Effects of blood flow restriction without additional exercise on strength reductions and muscular atrophy following immobilization:A systematic review显示文摘Purpose:To investigate whether blood flow restriction(BFR) without concomitant exercise mitigated strength reduction and atrophy of thigh muscles in subjects under immobilization for lower limbs.Methods:The following databases were searched:PubMed,CINAHL,PEDro,Web of Science,Central,and Scopus.Results:The search identified 3 eligible studies,and the total sample in the identified studies consisted of 38 participants.Isokinetic and isometric torque of the knee flexors and extensors was examined in 2 studies.Cross-sectional area of thigh muscles was evaluated in 1 study,and thigh girth was measured in 2 studies.The BFR protocol was 5 sets of 5 min of occlusion and 3 min of free flow,twice daily for approximately 2 weeks.As a whole,the included studies indicate that BFR without exercise is able to minimize strength reduction and muscular atrophy after immobilization.It is crucial to emphasize,however,that the included studies showed a high risk of bias,especially regarding allocation concealment,blinding of outcome assessment,intention-to-treat analyses,and group similarity at baseline.Conclusion:Although potentially useful,the high risk of bias presented by original stodies limits the indication of BFR without concomitant exercise as an effective countermeasure against strength reduction and atrophy mediated by immobilization. | Mikhail Santos Cerqueira Jose Diego Sales Do Nascimento Daniel Germano Maciel Jean Artur Mendonca Barboza Wouber Herickson De Brito Vieira | 2020 | Journal of Sport and Health Science2020，9，2： | 1 |
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