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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 3 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 4 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine(Phila Pa 1976)2000，25，20： | 1 |
| 5 | A prospective comparison of surgical approach for anterior L4-L5 fusion 显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 6 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | David SM | 2000 | Spine2000，1525，20： | 1 |
| 7 | Low-dose rituximab and alemtuzumab combination therapy for patients with steroidrefractory autoimmune eytopenias显示文摘 | David GA Manuel SG Luz TA | 2010 | Blood2010，116，23： | 1 |
| 8 | A prospective comparison of surgical approach for anterior L4-L5 fusion: laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 9 | A prospective comparison of surgical approach for anterior L4-L5 fusion: Laparoscopic versus mini anterior lumbar interbody fusion 显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，： | 1 |
| 10 | A prospective comparison of surgical approach for anterior L4-L5 fusion: laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine (Phila Pa 1976)2000，25，20： | 1 |
| 11 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 12 | A prospective comparison of surgical approach for anterior L4-L5 fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 13 | Expression of Leptin and Its Receptor in the Murine Ovary: Possible Role in the Regulation of Oocyte Maturation显示文摘 | Natalie KR Carole MW Kylie HV Robert BG David TA Robert JN | 2002 | Biology Of Reproduction2002，66，： | 1 |
| 14 | Technological advances in cold phacoemulsification cataract & refractive surgery today显示文摘 | David C Heilskov T Kangas TA Feist RM | 2002 | J Cataract Refract Surg2002，28，： | 1 |
| 15 | Hypnotic medication in the aftermath of trauma显示文摘 | Mellman TA Bustamante V David D | 2002 | J Clin Psychiat2002，63，12： | 1 |
| 16 | A prospective comparison of surgicalapproach for anterior L4-L5 fusion : laparoscopic versus minianterior lumbar interbody fusion 显示文摘 | Zdeblick TA David SM | 2000 | Spine ( Phila Pa 1976)2000，25，20： | 1 |
| 17 | A prospective comparison of surgical approach for anterior L4-5 fusion : laparoscopic versus mini anterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，： | 1 |
| 18 | Salivary gland tumors at in vivo proton MR spectroscopy显示文摘 | Ann KD David KW Anil TA | 2005 | Radiology2005，237，11： | 1 |
| 19 | A prospective comparison of surgical approach for anterior L4-L5 fusion:laparoscopic versus mini antereior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
| 20 | A Prospective comparision of sugical approach for anterior L4-L5 fusion laparoscopic versus minianterior lumbar interbody fusion显示文摘 | Zdeblick TA David SM | 2000 | Spine2000，25，20： | 1 |
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