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2篇 您的检索式：作者名="David L.Tabb"

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		题名	作者	年代	出处	被引量
	1	Basophile:Accurate Fragment Charge State Prediction Improves Peptide Identification Rates显示文摘In shotgun proteomics, database search algorithms rely on fragmentation models to predict fragment ions that should be observed for a given peptide sequence. The most widely used strategy (Naive model) is oversimplified, cleaving all peptide bonds with equal probability to produce fragments of all charges below that of the precursor ion. More accurate models, based on fragmentation simulation, are too computationally intensive for on-the-fly use in database search algorithms. We have created an ordinal-regression-based model called Basophile that takes fragment size and basic residue distribution into account when determining the charge retention during CID/higherenergy collision induced dissociation (HCD) of charged peptides. This model improves the accuracy of predictions by reducing the number of unnecessary fragments that are routinely predicted for highly-charged precursors. Basophile increased the identification rates by 26% (on average) over the Naive model, when analyzing triply-charged precursors from ion trap data. Basophile achieves simplicity and speed by solving the prediction problem with an ordinal regression equation, which can be incorporated into any database search software for shotgun proteomic identification.	Dong Wang Surendra Dasari Matthew C.Chambers Jerry D.Holman Kan Chen Daniel C.Liebler Daniel J.Orton Samuel O.Purvine Matthew E.Monroe Chang Y.Chung Kristie L.Rose David L.Tabb	2013	Genomics, Proteomics & Bioinformatics2013，11，2：	0
	2	性有适中的新的特种弹性体显示文摘前言一类新的特种弹性体在使用条件日益苛刻的今天处于特殊的地位。	Evic W.Thomas Denise A.Kotz David L.Tabb 田益民	1996	橡胶参考资料1996，26，6：	0

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