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您的检索式：作者名="David B.ALLISON"
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| 1 | Letter to the Editor: Exceptional Data in Paper on “The effect of meridian massage on BM, BMI, WC and HC in simple obesity patients: a randomized controlled trial”显示文摘14,November,2014Dear Editor:Given the tremendous need for effective weight loss treatments,we read with interest the paper by Yan et al.[1]and were intrigued by the reported finding that a form of massage produced weight loss in a randomized controlled trial. | Diana M.Thomas Andrew Brown John A Dawson Peng Li Steven B.Heymsfield David B.Allison | 2015 | World Journal of Acupuncture-Moxibustion2015，25，1： | 2 |
| 2 | Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster显示文摘In insects and other ectotherms,cold temperatures cause a coma resulting from loss of neuromuscular function,during which ionic and metabolic homeostasis are progressively lost.Cold adaptation improves homeostasis during cold exposure,but the ultimate targets of selection are still an open question.Cold acclimation and adaptation remodels mitochondrial metabolism in insects,suggesting that aerobic energy production during cold exposure could be a target of selection.Here,we test the hypothesis that cold adaptation improves the ability to maintain rates of aerobic energy production during cold exposure by using^(31)P NMR on live flies.Using lines of Drosophila melanogaster artificially selected for fast and slow recovery from a cold coma,we show that cold exposure does not lower ATP levels and that cold adaptation does not alter aerobic ATP production during cold exposure.Cold-hardy and cold-susceptible lines both experienced a brief transition to anaerobic metabolism during cooling,but this was rapidly reversed during cold exposure,suggesting that oxidative phosphorylation was sufficient to meet energy demands below the critical thermal minimum,even in cold-susceptible flies.We thus reject the hypothesis that performance under mild low temperatures is set by aerobic ATP supply limitations in D.melanogaster,excluding oxygen and capacity limitation as a weak link in energy supply.This work suggests that the modulations to mitochondrial metabolism resulting from cold acclimation or adaptation may arise from selection on a biosynthetic product(s)of those pathways rather than selection on ATP supply during cold exposure. | Caroline M.WILLIAMS James R.ROCCA Arthur S.EDISON David B.ALLISON Theodore J.MORGAN Daniel A.HAHN | 2018 | Integrative Zoology2018，13，4： | 0 |
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