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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | Role of Integrins in Cell Invasion and Migration显示文摘 | John DH David AC | 2002 | Nat Cancer Rev2002，，2： | 1 |
| 3 | Diagnosis and management of aneurysms involving the superior mesenteric artery and its branches:A report of four cases显示文摘 | David R Lorelli Robert AC | 2003 | Vasc Endovasc Surg2003，37，1： | 1 |
| 4 | Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystie ovary syndrome patients显示文摘 | Cheryl AC David HA | 2004 | J Clin Endocrinol Metab2004，89，7： | 1 |
| 5 | Risk of placenta previa in second birth after first birth cesarean section: a population-based study and meta-analysis显示文摘 | Ipek GU David AC Leroy CE | 2011 | BMC Pregnancy and Childbirth2011，11，： | 1 |
| 6 | Efficacy of superovualtion and intrauterine insemination in the treatment of infertility显示文摘 | David SG Sandra AC Christos C | 1999 | N Engl J Med1999，340，： | 1 |
| 7 | Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke?显示文摘 | David JW Ahmed TT Christopher AC | 2000 | J Neurol Neurosurg Psychiatry2000，69，： | 1 |
| 8 | Changes in human hepatic metabolism in steatosis and cirrhosis显示文摘AIM To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance(NMR) metabolomics analysis to human liver tissue.METHODS We have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis(NASH) or alcohol-related liver damage(ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries. RESULTS Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance. | Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor | 2017 | World Journal of Gastroenterology2017，23，15： | 1 |
| 9 | Guillain-Barr6 syndrome 显示文摘 | Richard AC David RC | 2005 | The Lancet2005，366，9497： | 1 |
| 10 | A randomized trial of vertebroplasty for osteoporotic spinal fractures显示文摘 | David FK Bryan AC Patrick JH | | 0，，： | 1 |
| 11 | Risk of placenta previa in second birth after first birth cesarean section:a population-based study and meta-analysis显示文摘 | Ipek GU David AC Leroy CE | 2011 | BMC Pregnancy and Childbirth2011，11，： | 1 |
| 12 | Histone methylation versus histone accetylation:new insights into epigenetic regulation 显示文摘 | Rice JC David AC | 2001 | Curr Opin Cell Biol2001，13，3： | 1 |
| 13 | Resistant hypertension, diagnosis, evaluation, and treatment: a scientific committee of the council for high blood pressure research statement from the American Heart Association professional education显示文摘 | David AC Danie Stephen 1' | 2008 | Hypertension2008，51，6： | 1 |
| 14 | The new oral anticoagulants显示文摘 | David G Edward L Mark AC | 2011 | Blood2011，115，1： | 1 |
| 15 | Assessment of acute and chronic pain显示文摘 | David AC | 2005 | Anaesthesia and Intensive Care Medicine2005，6，1： | 1 |
| 16 | Novel thiazolidine-2,4-diones as potent euglycemic agents显示文摘 | David AC Steven WG | 1992 | J Med Chem1992，35，10： | 1 |
| 17 | Polymeric worm micelles as nano - carriers for drug delivery 显示文摘 | Youngkoon K Paul D David AC | 2005 | Nanotechnology2005，7，： | 1 |
| 18 | Constructing validity:basic issues in objective scale development显示文摘 | Lee AC David W | 1995 | Psychol Assess1995，7，3： | 1 |
| 19 | Requirement of vescular integfinctvβ3 for angiogenesis 显示文摘 | Peter CB Richard AFC David AC | 1994 | Science1994，264，22： | 1 |
| 20 | Cost effectiveness ofantimicrobial catheters in the intensive care unit: addressinguncertainty in the decision显示文摘 | Kate AH David AC Michael W? | 2009 | Crit Care2009，13，2： | 1 |
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