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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Porphyromonas ging# valis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4 显示文摘 | Daveau RP Pham T]? Lemley K | 2004 | Infect lmmun2004，72，： | 1 |
| 3 | The inflammation-induced down-regulation of plasma Fetuin-A (2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites显示文摘 | Gangneux C Daveau M Hiron M | 2003 | Nucleic Acids Res2003，31，20： | 1 |
| 4 | MTNR1A melatonin receptors in the ovine premammillary hypothalamus:day-night variation in the expression of the transcripts显示文摘 | Migaud M Daveau A Malpaux B | | 0，，02： | 1 |
| 5 | MTNR1A melatonin receptors in the ovine premammillary hypothalamus:day-night variation in the expressionofthetranscripts显示文摘 | Migaud M Daveau A Malpaux B | 2005 | BiolReprod2005，72，2： | 1 |
| 6 | Evidence that melatonin acts in the premammillary hypothalamic area to control reproduction in the ewe: presence of binding sites and stimulation of luteinizing hormone secretion by in situ microimplant delivery显示文摘 | Daveau A Maurice MF | 1998 | Endocrinology1998，139，4： | 1 |
| 7 | Hepatocyte growth factor,transforming growth factor alpha,and their eceptors as combined markers of prognosis in hepatocellular carcinoma显示文摘 | Daveau M Scotte M Francois A | 2003 | [Journal Article]Molecular Carcinogenesis2003，36，3： | 1 |
| 8 | Inflammatory response following acute magnesium deficiency in the rat显示文摘 | MALPUECH-BRUGERE C NOWACKI W DAVEAU M | 2000 | Biochim Biophys Acta2000，1501，23： | 1 |
| 9 | Inflammatory response fol owing acute magnesium deficiency in the rat显示文摘 | Malpuech-Brugere C Nowacki W Daveau M | | 0，，： | 1 |
| 10 | The inflammation-induced down-regulation of plasma Fetuin A (alpha2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites显示文摘 | Gangneux C Daveau M Hiron M | 2003 | Nucleic Acids Res2003，31，20： | 1 |
| 11 | Genome-wide differences in hepatitis C-vs alcoholism-associated hepatocellular carcinoma显示文摘AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis C,10)and 5 controls.Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis C)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis C).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis.These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C.This may open novel avenues for differential therapies in this disease. | Céline Derambure Cédric Coulouarn Frédérique Caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois Celia Duclos Odile Goria Marie Gueudin Catherine Cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier | 2008 | World Journal of Gastroenterology2008，14，11： | 1 |
| 12 | Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes显示文摘 | Goeb V Thomas-Lr Otellier M Daveau R | 2009 | Arthritis Res Ther2009，11，2： | 1 |
| 13 | Contribution of PT- PN22 1858T, TNFRII 196R and HLA-shared epitope al- leles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis显示文摘 | Goeb V Dieude P Daveau R | 2008 | Rheumatology (Oxford)2008，47，8： | 1 |
| 14 | The synthesis of human alpha-2-HS glycoprotein is down-regulated by cytokines in hepatoma HepG2 cells显示文摘 | Daveau M Christian-INvrinche Julen N | 1988 | FEBS Lett1988，241，12： | 1 |
| 15 | Hepatocyte growth factor, transforming growth factor alpha and their receptors as combined markers of prognosis in hepato cellular carcinoma 显示文摘 | Daveau M Scotte M Fvancosis A | 2003 | Mol Carcinog2003，36，3： | 1 |
| 16 | Is regional lymph node irradiation necessary in stage ]l to 显示文摘 | Daveau C Stevens D Brain E | 2010 | Int J Radiat Oncol Biol Phys2010，78，： | 1 |
| 17 | Management of inflammatory breast cancer after neoadjuvant chemotherapy显示文摘 | Abrous-Anane S Savignoni A Daveau C | 2011 | Int JRadiat Oncol Biol Phys2011，79，4： | 1 |
| 18 | Evidence thatmelatonin acts in the premammillary hypothalamic area to controlreproduction in the ewe:presence of binding sites and stimulationof luteinizing hormone secretion by in situ microimplant delivery显示文摘 | Malpaux B Daveau A Maurice-Mandon F | 1998 | Endocrinology1998，139，4： | 1 |
| 19 | Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence显示文摘AIM:To search for transcription dysregulation that could(1) differentiate hepatocellular carcinoma(HCC)-free from HCC-related cirrhosis(2) differentiate HCC-free cirrhosis related to HCV from that related to alcohol intake.METHODS:Using microarray analysis,we compared transcript levels in HCC-free cirrhosis(alcoholism:7;hepatitis C:7),HCC-associated cirrhosis(alcoholism:10;hepatitis C:10) and eight control livers.The identified transcripts were validated by qRT-PCR in an independent cohort of 45 samples(20 HCC-free cirrhosis;15 HCC-associated cirrhosis and 10 control livers).We also confirmed our results by immunohistochemistry.transcripts which differentiated between alcoholic-related cirrhosis,HCV-related cirrhosis and control livers.They mainly corresponded to down-regulation.Dysregulation of Signal Transduction and Activator of Transcription-3(STAT-3) was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free cirrhosis.In contrast,in HCC,such transcription dysregulations were not observed.CONCLUSION:We report that transcriptional dysregulations exist in HCC-free cirrhosis,are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition. | Frédérique Caillot Céline Derambure Paulette Bioulac-Sage Arnaud Franois Michel Scotte Odile Goria Martine Hiron Maryvonne Daveau Jean-Philippe Salier | 2009 | World Journal of Gastroenterology2009，15，3： | 1 |
| 20 | Up - regulated expression of HGF in rat liver cells after experimental endotoxemia: a potential pathway for enhancement of liver regeneration 显示文摘 | Masson S Daveau M Francois A | 2001 | Growth Factors2001，18，4： | 1 |
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