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您的检索式：作者名="Datian LANG"
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| 1 | Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia显示文摘Ribonuclease 6(RNase6 or RNase K6)is a protein that belongs to a superfamily thought to be the sole vertebrate-specific enzyme known for a wide range of physiological functions,including digestion,cytotoxicity,angiogenesis,male reproduction and host defense.In our study,51 functional genes and 11 pseudogenes were identified from 27 Rodentia species.Intriguingly,in the 3 main lineages of rodents there were multiple RNase6s identified in all species of Ctenohystrica,whereas only a single RNase6 was observed in other Rodentia species examined except for 2 species in the mouse-related clade.The evolutionary scenario of“birth(gene duplication)and death(gene deactivation)”and gene sorting have been demonstrated in Ctenohystrica.In addition,bursts of positive selection,diversification of isoelectric point and positive net charge have been identified in Ctenohystrica,especially at two key sites that are involved in antimicrobial function.Site Trp30 has undergone positive selection and Ile45 has changed into other residues in Group B and Group C of the Ctenohystrica.Our results demonstrated a complex and intriguing evolutionary pattern of rodent RNase6,and indicated that functional modification may have occurred,which establishes an important theoretical foundation for future functional assays in rodent RNase6. | Datian LANG Burton KLIM Yun GAO Xiaoping WANG | 2019 | Integrative Zoology2019，14，3： | 1 |
| 2 | Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla显示文摘RNase9 plays a reproductive function and has been recognized as an important member of the ribonuclease(RNase)A superfamily,a gene family that is widely used as a model for molecular evolutionary studies.Here,we identified 178 RNase9 genes from 95 Cetartiodactyla species that represent all four lineages and 21 families of this clade.Unexpectedly,RNase9experienced an evolutionary scenario of“birth and death”in Ruminantia,and expression analyses showed that duplicated RNase9A and RNase9B genes are expressed in reproductive tissues(epididymis,vas deferens or prostate).This expression pattern combined with the estimate that these genes duplicated during the middle Eocene,a time when Ruminantia become a successful lineage,suggests that the RNase9 gene duplication might have been advantageous for promoting sperm motility and male fertility as an adaptation to climate seasonality changes of this period.In contrast,all RNase9 genes were lost in the Cetacean lineage,which might be associated with their high levels of prostatic lesions and lower reproductive rates as adaptations to a fully aquatic environment and a balance to the demands of ocean resources.This study reveals a complex and intriguing evolutionary history and functional divergence for RNase9 in Cetartiodactyla,providing new insights into the evolution of the RNaseA superfamily and molecular mechanisms for organismal adaptations to the environment. | Datian Lang Xiaoping Wang Chunbing Liu Weihang Geng David M.Irwin Shanyuan Chen Chunqing Li Li Yu Heng Xiao | 2023 | Science China(Life Sciences)2023，66，5： | 1 |
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