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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | A low does of Ghrelin srimulaetes growth hormone(GH) relase synergistically with GH-relesing hormone in huamans显示文摘 | DATA Y MURAKAMI N KOJIMA M | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 3 | Ghrelin,a novel growth hormone-releasing acylated peptide,is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans显示文摘 | DATA Y KOJIMA M HOSODA H | 2000 | Endocrinology2000，141，： | 1 |
| 4 | The role of the gastric afferent vngal never in ghrelin-induced feeding and growth hormone secretion in rats显示文摘 | DATA Y MURAKAMI N TOSHINAI K | 2002 | Gastroenterology2002，123，： | 1 |
| 5 | A role for ghrelin in the central regulation of feeding显示文摘 | NAKAZATO M MURAKANI N DATA Y | 2001 | Nature2001，409，6817： | 1 |
| 6 | A role for ghrelin in the central regulation of feeding 显示文摘 | NAKAZATO M MURAKAMI N DATA Y | 2001 | Nature2001，409，6817： | 1 |
| 7 | Biochemicalchanges in secondary metabolites in wounded anddeteriorated cassava roots 显示文摘 | Tanaka Y Data E S Hirose S | 1983 | Agricultural andBiological Chemistry1983，47，4： | 1 |
| 8 | The least squares mixing images derived from remote 显示文摘 | Shimabukuro Y E Smith J models to generate fraction sensing multispectral data A | 1991 | IEEE Transactions on Geoscience and Remote Sensing1991，29，1： | 1 |
| 9 | Arole for ghrelin in the central regulation of feeding显示文摘 | Murakami N Data Y | 2001 | Nature2001，409，： | 1 |
| 10 | Ghrelin is hormone releasing acylat- ed peptide from stomach 显示文摘 | Kojima M Hosoda H Data Y | 1999 | Nature1999，402，6762： | 1 |
| 11 | Gherlin is a growth- hormone-releasing acylated peptide from stomach显示文摘 | Kojma M Hosoda H Data Y | 1999 | Na- ture1999，402，6762： | 1 |
| 12 | A role for ghrelin in the central regulation of feeding 显示文摘 | NAKAZATO M MURAKAMI N DATA Y | 2001 | Nature2001，409，6817： | 1 |
| 13 | Arole for ghrelin in the central regulation of feeding 显示文摘 | Natazato M Murakami N Data Y | 2001 | Nature2001，409，： | 1 |
| 14 | Ghrelin is hormone re- leasing acylated peptide from stomach 显示文摘 | Kojima M Hosoda H Data Y et at | 1999 | Nature1999，402，6762： | 1 |
| 15 | Part I:Path radiance显示文摘 | KOTCHENOVA S Y VERMOTE E F MATARRESE R Validation of a vector version of the 6Sradiative transfer code for atmospheric correction of satellite data | 2006 | Applied Optics2006，45，26： | 1 |
| 16 | Nucleotide sequence and expression of rat beta-defensin-1:its significance in diabetic rodent models 显示文摘 | Hiratsuka T Nakazato M Data Y | 2001 | Nephron2001，88，1： | 1 |
| 17 | 1 Selectivity, latent-projective graph, datascope, local rank and unique resolution显示文摘 | Kvalheim O M Liang Y Z projections-resolving 2-way Heuristic evolving latent muhicomponent data | 1992 | Anal Chem1992，64，： | 1 |
| 18 | A role for ghrelin in the central regulation of feeding显示文摘 | Natazato M Murakani N Data Y | 2001 | Nature2001，409，： | 1 |
| 19 | SHI J of an shape adeoff study显示文摘 | AMSR-E data r near-circular synthesized ise/resolution tr Remote Sensing WNAG Y velopment re Q | 2007 | IEEE Trans2007，45，10： | 1 |
| 20 | Value of ultrasound examination in differential diagnosis of pancreatic lymphoma and pancreatic cancer显示文摘瞄准:在胰腺的淋巴瘤和胰腺的癌症的鉴别诊断调查临床的表明和超声检查的价值。方法:胰腺的淋巴瘤的 12 个案例和胰腺的癌症的 30 个案例的临床、超声的特征回顾地被分析。结果:统计上,有效差量在疾病,背疼痛,黄疸,carcino胚胎的抗原( CEA )和 CA19-9 期间被发现增加,摸得出的腹的块,表面的淋巴节点增大,发烧和盗汗,损害尺寸,胆汁管扩大,胰腺的管扩大,脉管的参与,制动火箭腹(下面,肾的静脉铺平)在胰腺的淋巴瘤和胰腺的癌症之间的淋巴节点增大,和肝内转移。在发作的年龄没有有效差量,性比率,重量损失,恶心并且呕吐,损害位置,损害的回响,和损害的血流。结论:胰腺的淋巴瘤应该与长持续为病人被考虑症状,表面的淋巴节点增大,摸得出的腹的块,发烧和盗汗,相对大的损害,和制动火箭腹(在肾的静脉的水平下面) 淋巴节点增大。胰腺的癌症的诊断应该与相对短的疾病路线,黄疸,背疼痛, CEA 和 CA19-9 在病人被认为更可能增加,相对小的损害,胆汁管扩大,明显的胰腺的管扩大,外部脉管的包装纸和参与,或肝内转移。 | Li Qiu Yan Luo Yu-Lan Peng Department of Ultrasound,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China Author contributions:Qiu L and Luo Y designed the research Qiu L,Luo Y and Peng YL did the ultrasound examination Qiu L and Peng YL collected the data Qiu L and Luo Y drafted and revised the manuscript and approved the final version. | 2008 | World Journal of Gastroenterology2008，14，43： | 1 |
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