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| 1 | Toll-like receptor expression and signaling in human diabetic wounds显示文摘AIM: To examine the contribution of toll-like receptors(TLRs) expression and activation to the prolonged inflammation often seen in human diabetic wounds.METHODS: Debridement wound tissue was collected from diabetic patients with informed consent. Total RNA and protein were isolated and subjected to real-time polymerase chain reaction and Western blot analyses. RESULTS: TLR1, 2, 4, and 6 mRNA expressions were increased significantly in wounds of diabetic patients compared with non-diabetic wounds(P < 0.05). MyD88 protein expression was significantly increased in diabetic wounds compared to non-diabetic wounds. Interleukin-1beta, tumor necrosis factor-alpha concentration nuclear factor-kappa B activation, and thiobarbituric acid reactive substances were increased in diabetic wounds compared to non-diabetic wounds(P < 0.01). CONCLUSION: Collectively, our novel findings show that increased TLR expression, signaling, and activation may contribute to the hyper inflammation in the human diabetic wounds. | Mohan R Dasu Sandra J Martin | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 2 | Role of TNF-alpha in gut mucosal changes after severe burn显示文摘 | Spies M Chappell VL Dasu MR | 2002 | Am J Physiol Gastrointest Liver Physiol2002，283，3： | 1 |
| 3 | Vitamin d deficiency and insulin resistance in normal and type 2 diabetes subjects显示文摘 | Bachali S Dasu K Ramalingam K | 2013 | Indian J Clin Biochem2013，28，1： | 1 |
| 4 | Diabetes is a proinflammatory state : a translational perspective 显示文摘 | Devaraj S Dasu MR Jialal I | 2010 | Expert Rev Endoerinol Metab2010，5，1： | 1 |
| 5 | Diabetes is a proinflammatory state:a translational perspective显示文摘 | Devaraj S Dasu MR Jialal I | 2010 | Expert Rev Endocrinol Metab2010，5，1： | 1 |
| 6 | Gene ex-pression profiles from hypertrophic scar fibroblasts beforeand after IL-6stimulation显示文摘 | Dasu MR Hawkins HK Barrow RE | 2004 | J Pathol2004，202，47： | 1 |
| 7 | Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes显示文摘 | Devaraj S Dasu MR Park SH | 2009 | Diabetologia2009，52，8： | 1 |
| 8 | C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo显示文摘 | Devaraj S Dasu MR Singh U | 2009 | Atherosclerosis2009，203，1： | 1 |
| 9 | Candesartan inhibits Toll-like receptor expression and activity hoth in vitro and in vivo 显示文摘 | Dasu MR Riosvelasco AC Jialal I | 2009 | Atherosclerosis2009，202，1： | 1 |
| 10 | Increased toll-like receptor(TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects显示文摘 | Dasu MR Devaraj S Park S | | 0，，04： | 1 |
| 11 | Increased toll- like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects显示文摘 | Dasu MR Devaraj S Park S | 2010 | Diabetes Care2010，33，4： | 1 |
| 12 | Increased toll-like receptor(TLR)activation and TLR ligands in recently diagnosed type 2 diabetic subjects显示文摘 | Dasu MR Devaraj S Park S | 2010 | Diabetes Care2010，33，4： | 1 |
| 13 | Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes显示文摘 | S. Devaraj M. R. Dasu S. H. Park I. Jialal | 2009 | Diabetologia2009，，8： | 1 |
| 14 | The relationship between temporal variation of hypoxia,polarographic measurements and P redictions of tumour response to radiation显示文摘 | Toma Dasu I Dasu A KarlssonM | 2004 | PhysMed Biol2004，49，19： | 1 |
| 15 | Increased toll -likereceptor (TLR) activation and TLR ligands in recentlydiagnosed type 2 diabetic subjects显示文摘 | Dasu MR Devaraj S Park S | 2010 | Diabetes Care2010，33，4： | 1 |
| 16 | Optimal operating policies in the pres- ence of exchange rate variability 显示文摘 | Dasu S Li L | 1997 | Management Sci- ence1997，43，5： | 1 |
| 17 | Optimization of microbiological parameters for enhanced griseofulvin production using response surface methodology 显示文摘 | Venkata Dasu V Panda T | 2002 | Bioprocess Engineering2002，22，： | 1 |
| 18 | Propionic acid production by whole cells of Propionibacterium freudeareichii显示文摘 | BALAMURUGAN K VENKATA DASU V PANDA T | 1999 | Bioprocess Eng1999，20，2： | 1 |
| 19 | The relationship between temporal variation of hypoxia, polarographic measurements and predictions of tumor response to radiation 显示文摘 | Toma-Dau I Dasu A Karlsson M | 2004 | Phys Med Biol2004，49，19： | 1 |
| 20 | Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes:further evidence of a proinflammatory state显示文摘 | Devaraj S Dasu MR Rockwood J | | 0，，： | 1 |
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