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| 1 | Current surgical treatments for Parkinson's disease and potential therapeutic targets显示文摘Currently, the most common surgical treatment for Parkinson's disease is deep brain stimulation(DBS). This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. In addition to DBS, ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. In this review, we discuss evolving surgical techniques, targets, and emerging technology. In addition, we evaluate potential paradigm shifts in treatment, including gene therapy, immunotherapy and cell transplantation. While these new techniques and treatment options are still in their infancy, advances in Parkinson's disease treatment are rapidly expanding. | Darrin J.Lee Robert F.Dallapiazza Philippe De Vloo Andres M.Lozano | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 2 | Cervical spine fractures in osteopetrosis:a case report and review of the literature显示文摘While management of appendicular fractures has been well described in the setting of osteopetrosis, there is limited information on managing fractures of the axial spine. Here we present an osteopetrotic patient with multiple traumatic multiple, comminuted, unstable cervical spinal fractures managed with non-operative stabilization, and provide a review of the pathophysiology, genetic characteristics, and special considerations that must be explored when determining operative versus non-operative management of spinal injury in osteopetrosis. A PubMed query was performed for English articles in the literature published up to June 2016, and used the following search terms alone and in combination: 'osteopetrosis', 'spine', 'fractures', 'osteoclasts', and 'operative management'. Within four months after initial injury, treatment with halo vest allowed for adequate healing. The patient was asymptomatic with cervical spine dynamic radiographs confirming stability at four months. On four-year follow up examination, the patient remained without neck pain, and CT scan demonstrated partially sclerotic fracture lines with appropriate anatomical alignment. In conclusion, external halo stabilization may be an effective option for treatment of multiple unstable acute traumatic cervical spine fractures in patients with osteopetrosis. Given the challenge of surgical stabilization in osteopetrosis, further research is necessary to elucidate the optimal form of treatment in this select patient population. | Arjang Ahmadpour Amir Goodarzi Darrin J.Lee Ripul R.Panchal Kee D.Kim | 2018 | The Journal of Biomedical Research2018，32，1： | 3 |
| 3 | Stereotactic guidance for navigated percutaneous sacroiliac joint fusion显示文摘Arthrodesis of the sacroiliac joint(SIJ) for surgical treatment of SIJ dysfunction has regained interest among spine specialists.Current techniques described in the literature most often utilize intraoperative fluoroscopy to aid in implant placement;however,image guidance for SIJ fusion may allow for minimally invasive percutaneous instrumentation with more precise implant placement.In the following cases,we performed percutaneous stereotactic navigated sacroiliac instrumentation using O-arm^(?)multidimensional surgical imaging with StealthStation^(?)navigation(Medtronic,Inc.Minneapolis,MN).Patients were positioned prone and an image-guidance reference frame was placed contralateral to the surgical site.O-arm^(?) integrated with StealthStation^(?) allowed immediate autoregistration.The skin incision was planned with an image-guidance probe.An image-guided awl,drill and tap were utilized to choose a starting point and trajectory.Threaded titanium cage(s) packed with autograft and/or allograft were then placed.O-arm^(?) image-guidance allowed for implant placement in the SIJ with a small skin incision.However,we could not track the cage depth position with our current system,and in one patient,the SIJ cage had to be revised secondary to the anterior breach of sacrum. | Darrin J.Lee Sung-Bum Kim Philip Rosenthal Ripul R.Panchal Kee D.Kim | 2016 | The Journal of Biomedical Research2016，30，2： | 1 |
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