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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Effect of immediate or delayed loading following immediate placement of implants with a modified surface显示文摘 | Linares A Mardas N Dard M Donos N | 2010 | Clin Oral Implants Res2010，，： | 1 |
| 3 | Internal rotation of the tibial component is frequent in stiff total knee arthroplasty显示文摘 | Bédard M Vince KG Redfern J | 2011 | 469(8):2346-23552011，469，8： | 1 |
| 4 | Are plants useful as accumulation indicators of metal bioavailability? 显示文摘 | REMON E BOUCHARDON J L LE GU DARD M | 2013 | Environmental Pollution2013，175，： | 1 |
| 5 | Immunomagnetic separation of Toxoplasma gondii oocysts using a monoclonal antibody directed against the oocyst wall显示文摘 | DUMeTRE A DARDe M L | 2005 | Journal of Microbiological Methods2005，61，2： | 1 |
| 6 | Differential effects of prostaglandin E(2)and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes显示文摘 | Weinberg E Topaz M Dard M | 2010 | J Periodontal Res2010，45，6： | 1 |
| 7 | Ground and excited state properties of carbozole-based dyads:correlation with their respective absorption and fluorescence spectra显示文摘 | Michel Belletete Mélanie Bédard Mario Leclerc | 2004 | Journal of Molecular Structure (TheoChem)2004，679，1： | 1 |
| 8 | Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome 显示文摘 | Barderas M G Tunon J Darde V M | 2009 | Proteomics2009，9，7： | 1 |
| 9 | Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase 显示文摘 | Zeldich E Koren R Dard M | 2010 | J Periodontal Res2010，45，2： | 1 |
| 10 | XORs in the air显示文摘 | Sachin Katti Hariharan Rahul Wenjun Hu Dina Katabi Muriel Médard Jon Crowcroft | 2008 | IEEE/ACM Transactions on Networking (TON)2008，，3： | 1 |
| 11 | Effect of interimplant dis-tance (2 and 3 mm)on the height of interimplant bone crest:a histomorphometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 12 | An algebraic approach to network coding显示文摘 | Koetter R Médard M | | 0，，05： | 1 |
| 13 | Network coding in next-genera- tion passive optical networks 显示文摘 | FOULI K MAIER M MI~DARD M | 2011 | IEEE Communications Magazine2011，49，9： | 1 |
| 14 | Effect of interimplant distance (2 and 3 mm) on the height of interimplant bone crest: a histomor- phometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 15 | Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning 显示文摘 | Grandin HM Gemperli AC Dard M | 2012 | Tissue engineering part B-reviews2012，18，3： | 1 |
| 16 | Enamel matrix deriva- tive induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via ex- tracellular signal-regulated kinase 显示文摘 | Zeldich E Koren R Dard M | 2010 | J Periodontal Res2010，45，2： | 1 |
| 17 | Effect of interimplant distance (2and 3 mm)on the height of interimplant bone crest: a histomor-phometric evaluation 显示文摘 | Elian N Bloom M Dard M | 2011 | J Periodontol2011，82，12： | 1 |
| 18 | 显示文摘 | Darde V Van Well W J M Fosboel P L | 2011 | Int J Greenh Gas Con2011，5，5： | 1 |
| 19 | Depletion of high-abundance proteins in plasma by immunoaffinity subtraction for two-dimensional difference gel electrophoresis analysis显示文摘 | DARDE V M BARDERAS M G VIVANCO F | 2007 | Methods Mol Biol2007，357，： | 1 |
| 20 | Chilled ammonia process for CO2 capture显示文摘 | Darde V Thomsen K van Well W J M | 2009 | Energy Procedia2009，1，1： | 1 |
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