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您的检索式：作者名="Danxia Guo"
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| 1 | Application of proprotein convertase subtilisin/kexin type 9 inhibitor, evolocumab, in patients with severe hypertriglyceridemia显示文摘To the Editor:The proprotein convertase subtilisin/kexin type 9(PCSK9)-inhibitor,evolocumab,can bind with PCSK9 in plasma and reduce the degradation of the PCSK9-low density lipoprotein(LDL)receptor complex,thereby reducing LDL levels.[1]In clinical practice,PCSK9 inhibitors can reduce low-density lipoprotein cholesterol(LDL-c)significantly and reduce triglycerides(TG)by about 8%to 17%.[2]We used PCSK9 inhibitors to lower blood lipids in three patients with severe hypertriglyceridemia(HTG)and performed whole-exome sequencing(WES)to analyze the genes that may contribute to hyperlipidemia in detail.We have obtained patients'consent forms.We found that PCSK9 inhibitors significantly reduced blood lipid levels,regardless of the presence of HTG mutations.These results provide new evidence for the use of PCSK9 inhibitors in the treatment of patients with severe HTG. | Yanren Peng Danxia Guo Sijie Jiang Hua Zheng | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 2 | 线粒体自噬决定肌肉与脂肪之间的对话来改善饮食导致的肥胖显示文摘文章简介线粒体质量控制是骨骼肌糖脂代谢功能及其应答生理或病理反应所必需的。然而,人们对于骨骼肌线粒体质量是如何控制的,以及这一控制机制的生理功能十分不清楚。本研究发现,线粒体外膜蛋白FUNDC1在调节骨骼肌线粒体质量以及机体代谢稳态维持中起着至关重要的作用。 | 付婷婷 徐志圣 Lin Liu Qiqi Guo Hao Wu Xijun Liang Danxia Zhou Liwei Xiao Lei Liu Yong Liu Min-Sheng Zhu 陈佺 甘振继 | 2019 | 科学新闻2019，0，2： | 0 |
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